期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 22, 页码 5153-5167出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3270-17.2018
关键词
excitation-inhibition balance; burst coding; feedforward inhibition; Purkinje cell; short-term dynamics
资金
- Centre National pour la Recherche Scientifique
- Universite de Strasbourg
- Agence Nationale pour la Recherche Grant [ANR-15-CE37-0001-01 CeMod]
- Fondation pour la Recherche Medicale [DEQ20140329514]
- Ministere de la Recherche
- Fondation pour la Recherche Medicale fellowship
- Parkinsonfonden Sweden
- Strategic Research Area Neuroscience (StratNeuro) program of Sweden
The balance between excitation (E) and inhibition (I) in neuronal networks controls the firing rate of principal cells through simple network organization, such as feedforward inhibitory circuits. Here, we demonstrate in male mice, that at the granule cell (GrC)molecular layer interneuron (MLI)-Purkinje cell (PC) pathway of the cerebellar cortex, E/I balance is dynamically controlled by short-term dynamics during bursts of stimuli, shaping cerebellar output. Using a combination of electrophysiological recordings, optogenetic stimulation, and modeling, we describe the wide range of bidirectional changes in PC discharge triggered by GrC bursts, from robust excitation to complete inhibition. At high frequency (200 Hz), increasing the number of pulses in a burst (from 3 to 7) can switch a net inhibition of PC to a net excitation. Measurements of EPSCs and IPSCs during bursts and modeling showed that this feature can be explained by the interplay between short-term dynamics of the GrC-MLI-PC pathway and E/I balance impinging on PC. Our findings demonstrate that PC firing rate is highly sensitive to the duration of GrC bursts, which may define a temporal-to-rate code transformation in the cerebellar cortex.
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