Article
Cell Biology
Giuseppe Balsamo, Eduardo Blanco-Hernandez, Feng Liang, Robert Konrad Naumann, Stefano Coletta, Andrea Burgalossi, Patricia Preston-Ferrer
Summary: Research on the mouse dorsal presubiculum demonstrates a modular patch-matrix organization that is conserved across species, including human. The restricted apical dendrites of HD cells within the matrix suggest a non-random sampling of patterned inputs and a precise structure-function architecture in the cortical representation of HD.
Article
Clinical Neurology
Laura Convertino, Daniel Bush, Fanfan Zheng, Rick A. Adams, Neil Burgess
Summary: Convertino et al. found that individuals with schizophrenia do not exhibit the hexadirectional modulation of theta power in the right entorhinal cortex, as seen in a control group. This lack of modulation may contribute to impairments in spatial and relational cognition observed in schizophrenia. The study also suggests that disruptions in grid firing patterns in the entorhinal cortex may be associated with the pathophysiology of schizophrenia.
Article
Chemistry, Multidisciplinary
Xiaoyang Long, Bin Deng, Calvin K. Young, Guo-Long Liu, Zeqi Zhong, Qian Chen, Hui Yang, Sheng-Qing Lv, Zhe Sage Chen, Sheng-jia Zhang
Summary: Head direction cells are an important component in the brain's spatial navigation system. FS HD cells in the somatosensory cortex display sharper head-directionality than RS HD cells and coexist with RS HD cells and AHV cells in a layer-specific manner. These findings challenge the concept that FS interneurons are weakly tuned to sensory stimuli and provide insights into the local circuit organization of HD signaling in the brain.
Review
Physiology
John J. Tukker, Prateep Beed, Michael Brecht, Richard Kempter, Edvard Moser, Dietmar Schmitz
Summary: This review focuses on recent investigations of intrinsic connectivity in the medial entorhinal cortex (MEC), which have started to describe and quantify both excitatory and inhibitory wiring in the superficial layers of the MEC. These findings contribute to a deeper understanding of the mechanisms underlying spatial navigation and memory.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Ingvild Ulsaker-Janke, Torgeir Waaga, Tanja Waaga, Edvard I. Moser, May - Britt Moser
Summary: This study found that rats can develop grid-like neuron firing patterns in a specific environment, even without stable reference boundaries to guide them. After a few trials of training, these patterns become more clear. While some experience with external spatial boundaries is required for the expression of grid patterns in a new environment, this restricted spatial experience can be overcome with short-term training.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Mehdi Fallahnezhad, Julia Le Mero, Xhensjana Zenelaj, Jean Vincent, Christelle Rochefort, Laure Rondi-Reig
Summary: The head-direction (HD) system is a neural circuit crucial for navigation, consisting of anatomical structures with neurons selective to the animal's head direction. HD cells display temporal coordination across brain regions, independent of the animal's behavior or sensory inputs, which mediates a single, stable, and persistent HD signal necessary for intact orientation. By manipulating the cerebellum, researchers identify pairs of HD cells recorded from two brain structures that lose their temporal coordination, specifically during the removal of external sensory inputs. The cerebellum contributes to the preservation of a single and stable sense of direction through distinct mechanisms depending on sensory signals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Horst A. Obenhaus, Weijian Zong, R. Irene Jacobsen, Tobias Rose, Flavio Donato, Liangyi Chen, Heping Cheng, Tobias Bonhoeffer, May-Britt Moser, Edvard Moser
Summary: The study found that grid cells in the medial entorhinal cortex (MEC) exhibit distinct organization compared to border, head-direction, and object-vector cells, with strong coupling among themselves but weaker connections to other cell types.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Yijia Yan, Neil Burgess, Andrej Bicanski
Summary: This study presents a computational model explaining how visual feedback can stabilize head direction (HD) information in environments with multiple cues of varying stability and directional specificity. The model predicts neurons with a unimodal encoding of the egocentric orientation of landmark arrays, allowing the landmark bearing signal to disconnect from directionally unstable or ephemeral cues and support orientation across different environments.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Simone Vigano, Valerio Rubino, Antonio Di Soccio, Marco Buiatti, Manuela Piazza
Summary: The human brain represents relational information about words through grid-like and distance-dependent codes, as shown in a study where participants learned the meaning of novel words while performing a word comparison task.
Article
Behavioral Sciences
Osman Akan, Anne Bierbrauer, Lukas Kunz, Patrick D. Gajewski, Stephan Getzmann, Jan G. Hengstler, Edmund Wascher, Nikolai Axmacher, Oliver T. Wolf
Summary: Repeated exposure to chronic stress can impair cognitive functions such as long-term memory and navigation. It is still unclear whether chronic stress affects path integration, a navigational strategy that relies on the functioning of grid cells in the entorhinal cortex. This study aimed to investigate the association between chronic stress and path integration performance, and the results suggest a potential impairment of path integration due to chronic stress.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Susumu Takahashi, Takumi Hombe, Sakiko Matsumoto, Kaoru Ide, Ken Yoda
Summary: Animals demonstrate remarkable navigation abilities, possibly due to the presence of head direction cells that encode the animal's heading information. In the study of shearwater chicks, it was found that their head direction cells exhibited a preference for the north direction, indicating the existence of an internally generated magnetic compass in animals.
Article
Neurosciences
Paul E. C. Mertens, Pietro Marchesi, Thijs R. Ruikes, Matthijs Oude Lohuis, Quincy Krijger, Cyriel M. A. Pennartz, Carien S. Lansink
Summary: The study shows that neurons in the brain not only transmit current visual information but also contextual information such as reward expectancy and spatial position. This contextual representation is not limited to the visual cortex, but can be found throughout sensory cortices. The findings suggest that sensory cortices participate in coherent, multimodal representations of the subject's sensory-specific location.
Editorial Material
Biochemistry & Molecular Biology
Aylin Apostel, Jonas Rose
Summary: The study found head-direction cells, but not place cells, in the hippocampal formation of quails, shedding light on the poorly understood avian hippocampus.
Article
Multidisciplinary Sciences
Mei-Heng Lin, Omer Liran, Neeta Bauer, Travis E. Baker
Summary: This study investigated theta dynamics in freely moving humans navigating a T-maze using mobile-EEG and virtual reality. The results showed theta power increases during decision-making, as well as for fast and leftward trials approaching the goal, and evoked theta bursts during feedback onset.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
David B. Omer, Liora Las, Nachum Ulanovsky
Summary: This study identified two distinct populations of time cells in the bat hippocampal area CA1. One population encoded different temporal sequences based on the bat's location, thus encoding both spatial context and time. The other population encoded similar preferred times across different spatial contexts, purely encoding elapsed time. Additionally, time cells were found to encode temporal sequences aligned to another bat's landing in a social imitation task. These diverse time codes may support interval timing perception, episodic memory, and temporal coordination between self and others.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Holger Dannenberg, James R. Hinman, Michael E. Hasselmo
JOURNAL OF PHYSIOLOGY-PARIS
(2016)
Review
Neurosciences
Holger Dannenberg, Kimberly Young, Michael Hasselmo
FRONTIERS IN NEURAL CIRCUITS
(2017)
Article
Neurosciences
Laszlo Zaborszky, Peter Gombkoto, Peter Varsanyi, Matthew R. Gielow, Gina Poe, Lorna W. Role, Mala Ananth, Prithviraj Rajebhosale, David A. Talmage, Michael E. Hasselmo, Holger Dannenberg, Victor H. Minces, Andrea A. Chiba
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Holger Dannenberg, Craig Kelley, Alec Hoyland, Caitlin K. Monaghan, Michael E. Hasselmo
JOURNAL OF NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
James R. Hinman, G. William Chapman, Michael E. Hasselmo
NATURE COMMUNICATIONS
(2019)
Article
Neurosciences
Holger Dannenberg, Andrew S. Alexander, Jennifer C. Robinson, Michael E. Hasselmo
JOURNAL OF COGNITIVE NEUROSCIENCE
(2019)
Editorial Material
Neurosciences
Michael E. Hasselmo, Andrew S. Alexander, Holger Dannenberg, Ehren L. Newman
Article
Multidisciplinary Sciences
Andrew S. Alexander, Lucas C. Carstensen, James R. Hinman, Florian Raudies, G. William Chapman, Michael E. Hasselmo
Review
Neurosciences
Michael E. Hasselmo, Andrew S. Alexander, Alec Hoyland, Jennifer C. Robinson, Marianne J. Bezaire, G. William Chapman, Ausra Saudargiene, Lucas C. Carstensen, Holger Dannenberg
Summary: The space of possible neural models is vast and not fully explored, requiring a framework to represent what has been explored and what has not. Current network models mainly focus on excitatory weight matrices and firing thresholds, without addressing the complexities such as the effects of metabotropic receptors on intrinsic properties.
Article
Biology
Holger Dannenberg, Hallie Lazaro, Pranav Nambiar, Alec Hoyland, Michael E. Hasselmo
Article
Neurosciences
Jeffrey D. D. Kopsick, Kyle Hartzell, Hallie Lazaro, Pranav Nambiar, Michael E. E. Hasselmo, Holger Dannenberg
Summary: This study investigates the temporal dynamics of cholinergic activity in freely moving mice using a fiber-photometric method. The results show that cholinergic modulation changes rapidly and is linearly correlated with the animal's running speed and neck movement speed. Additionally, cholinergic modulation remains constant in darkness, and standing behavior leads to higher cholinergic activity.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Review
Behavioral Sciences
Michael E. Hasselmo, James R. Hinman, Holger Dannenberg, Chantal E. Stern
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2017)