Article
Immunology
Jiayuan Wu, Xinqin Xu, Li Zheng, Juanfen Mo, Xiuhui Jin, Yi Bao
Summary: Nilotinib has been shown to suppress microglia-mediated neuroinflammatory response and protect DA neurons from inflammatory damage, suggesting its potential application in further clinical trials.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Justina Pajarskiene, Vytautas Kaseta, Kristina Vaiksnoraite, Virginijus Tunaitis, Augustas Pivoriunas
Summary: miR-124 is widely expressed in nervous tissue and acts as a negative regulator of neuroinflammation. The study found that miR-124 exerts its anti-inflammatory effect by suppressing the MyD88-NF kappa B pathway, downregulating pro-inflammatory cytokines IL-1 beta and IL-6, enhancing the TRAM-TRIF signaling, and increasing IFN-beta expression. Additionally, specific changes in NF kappa B activity induced by miR-124 were only detected using NF kappa B reporter promoters lacking ATF/CREB binding site.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Review
Immunology
Yongli Pan, Ting Wang, Zhiqiang Zhao, Wei Wei, Xinyu Yang, Xianbin Wang, Wenqiang Xin
Summary: This article reviews the regulation of Neat1 and its modulation of target gene expression, and explores the impact of Neat1 on inflammation, including activation or inhibition of various signaling pathways.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Jianjian Dong, Xun Wang, Chenchen Xu, Manli Gao, Shijing Wang, Jin Zhang, Haiyang Tong, Lulu Wang, Yongzhu Han, Nan Cheng, Yongsheng Han
Summary: The study demonstrates that copper-mediated neuroinflammation is associated with the activation of the NLRP3 inflammasome, contributing to progressive neuropathology in a murine model of WD. Blocking the activation of the NLRP3 inflammasome effectively mitigates cognitive decline, locomotor behavior impairment, and neurodegeneration in the mice.
CELL DEATH & DISEASE
(2021)
Review
Geriatrics & Gerontology
Mobina Fathi, Kimia Vakili, Shirin Yaghoobpoor, Mohammad Sadegh Qadirifard, Mohammadreza Kosari, Navid Naghsh, Afsaneh Asgari Taei, Andis Klegeris, Mina Dehghani, Ashkan Bahrami, Hamed Taheri, Ashraf Mohamadkhani, Ramtin Hajibeygi, Mostafa Rezaei Tavirani, Fatemeh Sayehmiri
Summary: Parkinson's disease is characterized by neuroinflammation, and several protein factors and pathways are implicated in the development of PD and other neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Hua Cao, Xinsheng Han, Yonglin Jia, Baohua Zhang
Summary: The study reveals that HOXA11-AS plays a role in promoting inflammation in Parkinson's disease, leading to neuronal damage and microglia activation. Conversely, miR-124-3p has opposite effects by inhibiting inflammation. By modulating the interactions among these molecules, the neurological damages caused by PD can be alleviated.
Article
Immunology
Soudeh Ghafouri-Fard, Mahdi Gholipour, Atefe Abak, Mehrdokht Mazdeh, Mohammad Taheri, Arezou Sayad
Summary: The study showed significant differences in the expressions of NF-kappa B-related lncRNAs between PD patients and healthy controls, with certain gene expressions being associated with the pathogenesis of PD and correlated with each other. Among the evaluated genes, CEBPA demonstrated the best performance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin Geng, Shipeng Li, Jinghui Li, Renli Qi, Lianmei Zhong, Hualin Yu
Summary: This study found that MDMA promoted the expression of MALAT1 and inhibited the targeted downregulation of MEKK3 by miR-124, resulting in upregulation of MEKK3 expression and jointly promoting the progression of PD.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Dewei He, Guiqiu Hu, Ang Zhou, Yanting Liu, Bingxu Huang, Yingchun Su, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Shoupeng Fu, Dianfeng Liu
Summary: This study found that Echinocystic acid (EA) inhibits neuroinflammation by activating the PI3K/Akt pathway and inhibiting the NF-kappa B and MAPK pathways, and exhibits neuroprotective effects in vivo and in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Lin Wei, Xiaowen Yang, Jie Wang, Zhixiao Wang, Qiguang Wang, Yan Ding, Aiqing Yu
Summary: Cellular senescence is a fundamental activity driving the aging process and is closely associated with age-related diseases, including Alzheimer's disease (AD). In this study, the elevated levels of lactic acid in senescent microglia and hippocampus tissues of naturally aged mice and AD mice models were quantified. The study also identified the role of H3K18la/NF?B axis in modulating the production of IL-6 and IL-8, which are components of the senescence-associated secretory phenotype (SASP).
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Immunology
Frida Lind-Holm Mogensen, Andrea Scafidi, Aurelie Poli, Alessandro Michelucci
Summary: Microglia are immune cells in the brain that play important roles in immune surveillance and neuroprotection. However, they can also contribute to neuroinflammation and neurotoxicity in neurodegenerative diseases like Parkinson's disease. This review focuses on the role of DJ-1, a protein encoded by the PARK7 gene, in microglia genetic programs and immunological traits. It also discusses the potential of targeting dysregulated pathways in microglia under DJ-1 deficiency as therapeutic approaches for PD, and proposes considering DJ-1 as a biomarker and using DJ-1-enhancing compounds to reduce oxidative stress and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Oncology
Ting Li, Yun Xin Zhai, Tianyi Zheng, Bing Xu
Summary: In this study, neferine was found to suppress the activation of microglia and attenuate neuroinflammation, providing potential therapeutic options for Parkinson's disease.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Pharmacology & Pharmacy
Shuhan Liu, Shengxiang Wang, Runze Gu, Na Che, Jing Wang, Jinbo Cheng, Zengqiang Yuan, Yong Cheng, Yajin Liao
Summary: This study demonstrates that KPT-8602 has potent anti-inflammatory effects and could be used as a novel therapeutic agent for inflammasome-related diseases, such as Parkinson's disease, through the regulation of the NF-kappa B signaling pathway and the NLRP3 inflammasome.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Longping Yao, Zhiyuan Zhu, Jiayu Wu, Yizhou Zhang, Hongbo Zhang, Xiang Sun, Chen Qian, Baoyan Wang, Linghai Xie, Shizhong Zhang, Guohui Lu
Review
Oncology
Longping Yao, Mohammed Alahmari, Yasin Temel, Koos Hovinga
Review
Cell Biology
Longping Yao, Jiayu Wu, Sumeyye Koc, Guohui Lu
Summary: Parkinson's disease is a prevalent neurodegenerative aging disorder characterized by motor and non-motor symptoms due to the selective loss of midbrain dopaminergic neurons. Chronic inflammation of the central nervous system, mediated by microglial cells, may play a role in neurodegeneration, exacerbating the primary morbid process. Genetic factors such as LRRK2 and SNCA are crucial in the occurrence and development of PD and neuroinflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Medicinal
Hanwen Zhang, Longping Yao, Zijian Zheng, Sumeyye Koc, Guohui Lu
Summary: Studies suggest that alterations in non-coding RNAs play a role in the pathogenesis of Parkinson's disease, potentially serving as biomarkers and regulators of disease-related pathways at the cellular level.