期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 4, 页码 778-784出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00764
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资金
- ASAFEM Project under the ERAfrica Programme [IC-070]
- German Academic Exchange Service (DAAD)
- Kenya National Council for Science and Technology (NACOSTI)
- Science Without Border (Ciencias sem Fronteiras) Program of Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) from Brazil
- Conselho Nacional de Desenvolvimento Cientifico e TecnolOgico (CNPq) from Brazil
The need for effective compounds to combat antimicrobial resistance and biofilms which play important roles in human infections continues to pose a major health challenge. Seven previously undescribed acyclic diterpenes linked to isocitric acid by an ether linkage, microporenic acids A-G (1-7), were isolated from the cultures of a hitherto undescribed species of the genus Microporus (Polyporales, Basidiomycota) originating from Kenya's Kakamega forest. Microporenic acids D and E (4 and 5) showed antimicrobial activity against a panel of Gram positive bacteria and a yeast, Candida tenuis. Moreover, microporenic acids A and B (1 and 2) demonstrated dose-dependent inhibition of biofilm formation by Staphylococcus aureus. Compound 1 further showed significant activity against Candida albicans and Staphylococcus aureus preformed biofilms.
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