Article
Chemistry, Multidisciplinary
Yongzhi Wu, Fangman Chen, Nengwen Huang, Jinjin Li, Chenzhou Wu, Bowen Tan, Yunkun Liu, Longjiang Li, Chao Yang, Dan Shao, Jinfeng Liao
Summary: Light-stimulus-responsive hydrogels incorporating mesoporous silica nanoparticles as doxorubicin carriers were developed for on-demand chemo-photothermal therapy of OSCC. The combination of chemotherapy and phototherapy achieved a long-lasting synergistic anti-tumor effect with less toxicity in vitro and in vivo.
Article
Nanoscience & Nanotechnology
Wenhua Zhan, Hanrui Li, Yingying Guo, Lu Yang, Liaojun Pang, Chaolin Zhang
Summary: Chemotherapy is limited by drug toxicity and side effects in treating breast cancer, but the combination of photothermal therapy with chemotherapy shows promise. A biodegradable mesoporous silica nanoparticle (bMSN NPs) system for loading doxorubicin (DOX) and IR780 has shown excellent therapeutic effects on breast cancer cells in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Sadaf Hameed, Pravin Bhattarai, Zhuoran Gong, Xiaolong Liang, Xiuli Yue, Zhifei Dai
Summary: This study focuses on the synthesis of ultra-small hydrophilic porphyrin-based silica nanoparticles to enhance the treatment outcomes of cancer via photodynamic therapy. These nanoparticles show excellent solubility in water, enhanced tumor accumulation, and imaging-guided therapeutic abilities. They also exhibit biocompatibility and stability in physiological solutions.
NANOSCALE ADVANCES
(2022)
Article
Pharmacology & Pharmacy
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Daria B. Trushina, Anastasiia Yu Sapach, Olga A. Burachevskaia, Pavel Medvedev, Dmitry N. Khmelenin, Tatiana N. Borodina, Mikhail A. Soldatov, Vera V. Butova
Summary: In this study, biocompatible high-capacity UiO-66 nanoparticles, mesoporous SiO2, and folate-conjugated pluronic F127 were combined to prepare a core-shell UiO-66@SiO2/F127-FA drug delivery carrier for targeted cellular uptake in cancer treatment. The thickness of the SiO2 shell was controlled by varying the duration of silanization, and silica coating improved the colloidal stability of the nanocomposites. Further modification with the conjugate of pluronic and folic acid enhanced biocompatibility and targeted the encapsulated drug to folate-expressing cancer cells.
Article
Biochemistry & Molecular Biology
Rosa M. Giraldez-Perez, Elia Grueso, Antonio J. Montero-Hidalgo, Raul M. Luque, Jose M. Carnerero, Edyta Kuliszewska, Rafael Prado-Gotor
Summary: In this study, different gold nanosystems were designed and synthesized for cancer therapy. It was found that gold nanoparticles can induce compaction of DNA-Doxo, enabling efficient drug delivery with high selectivity towards cancer cells. In vitro experiments showed that these compacted nanocomplexes exhibit strong therapeutic effects in cancer cell lines, while protecting non-tumor cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Mahshid Deldar Abad Paskeh, Hamidreza Saebfar, Mahmood Khaksary Mahabady, Sima Orouei, Kiavash Hushmandi, Maliheh Entezari, Mehrdad Hashemi, Amir Reza Aref, Michael R. Hamblin, Hui Li Ang, Alan Prem Kumar, Ali Zarrabi, Saeed Samarghandian
Summary: Gene therapy can be used as a cancer therapy by affecting signaling networks participating in the aggressive behavior of tumors. Small interfering RNA (siRNA) is a genetic tool employed to increase drug sensitivity and reduce drug resistance. By targeting oncogenic pathways and regulating drug transporter activity, siRNA can increase drug accumulation and enhance cytotoxicity. The use of nanoparticles as carriers and smart nanostructures with pH, redox, and light responsiveness can optimize siRNA and drug delivery for tumor treatment.
Review
Multidisciplinary Sciences
Yingqi Liu, Yunyun Wu, Zhong Luo, Menghuan Li
Summary: Stimuli-responsive nanomaterials have been attracting significant attention in the field of cancer therapy, as they offer the potential to deliver anticancer drugs to tumor sites with precision and on-demand. Supramolecular chemistry, which involves reversible bonding at the molecular and nanoscale levels, has advanced the design of nanotherapeutics with enhanced control and functionality. This review provides a comprehensive summary of non-covalent interaction modes, such as hydrophobic interaction, hydrogel bonding, host-guest interaction, pi-pi stacking, and electrostatic interaction, and discusses their implications for designing stimuli-responsive drug delivery systems to improve spatial, temporal, and dosage precision. The review also highlights current challenges and future opportunities in self-assembly-based stimuli-responsive drug delivery nanotechnologies for cancer therapy.
Article
Engineering, Biomedical
Xiaoli Wu, Han Yang, Xingmeng Chen, Junxiao Gao, Yue Duan, Daohe Wei, Jinchao Zhang, Kun Ge, Xing-Jie Liang, Yuanyu Huang, Sizhou Feng, Rongli Zhang, Xi Chen, Jin Chang
Summary: A new immunotherapy approach combining innate immune activator and photodynamic therapy reagent has shown promising results in treating colon cancer, effectively inhibiting tumor growth, promoting immune cell infiltration, and enhancing cytotoxicity of immune cells. This approach may serve as an effective and safe platform for combinatory use with nano-herb medicine and PDT, providing a new therapy option for colon cancer treatment.
Article
Pharmacology & Pharmacy
Guoliang Liu, Min Wang, Hongyu He, Jiannan Li
Summary: This study developed tumor-targeting nanoparticles loaded with doxorubicin for the treatment of colorectal cancer. The nanoparticles utilize a peptide, VATANST (STP), to achieve tumor-targeting effects, have a core-shell structure, and are sensitive to the tumor microenvironment. In vivo experiments in mice demonstrated the nanoparticles' properties as drug delivery systems and their good antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yi Zhang, Qing Jiang, Xinyi Liu, Liping Peng, Xinyi Tang, Ling Li, Xiao Ling, Xiaoping Yang, Chunlian He, Xiaojun Tao, Defu Hou
Summary: The study investigated the impact of hydrophobic groups on the structural properties and function of polymer nanoparticles. The results demonstrated that polymer NPs with higher hydrophobicity exhibited smaller size, higher drug capacity, and greater cell efficiency.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Ruoshi Zhang, Xin Wang, Na Fan, Jing Li
Summary: The Fe(III) loaded porous silica nanoparticles have shown promising potential for establishing an anticancer drug delivery system. Through pH-triggered release and high anti-cancer activity, DOX loaded MM-SN-NH2-Fe demonstrated superior efficacy in both in vitro and in vivo experiments.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Biochemical Research Methods
Jing Wu, Yan Xu, Jiahong Yang, Xinyue Yu, Zhaodi Han, Linling Guo, Yin Huang, Yuxin Zhang
Summary: This study developed a novel LC-MS/MS method for quantification of 10 B vitamins in mouse colon tissue. The method was validated according to FDA guidelines and produced good results in terms of linearity, accuracy, precision, recovery, matrix effect, and stability. Application of the method revealed significant colon damage and accumulation of multiple B vitamins after doxorubicin treatment in mice with breast cancer.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Qingtao Song, Yilin Liu, Xiaoyong Ding, Miao Feng, Jing Li, Wenjuan Liu, Bohan Wang, Zhongwei Gu
Summary: An active drug delivery platform of Mg micromotors is proposed to overcome MDR and enhance drug permeability for treating HCC.
Article
Chemistry, Multidisciplinary
Qingtao Song, Yilin Liu, Xiaoyong Ding, Miao Feng, Jing Li, Wenjuan Liu, Bohan Wang, Zhongwei Gu
Summary: An active drug delivery platform of Mg micromotors is proposed to overcome MDR and enhance drug permeability for treating HCC. The platform, made of biocompatible materials, allows autonomous motion and increases the diffusion of chemotherapy drugs, leading to improved drug distribution within cells. Moreover, the hydrogen produced during the motion helps eliminate reactive oxygen species in cells. Compared to inert groups, the absorption of drugs from the active micromotors is significantly higher. At a concentration of 1 mg/mL, the micromotors also exhibit enhanced anti-tumor activity, reducing cell proliferation by almost 30%.
