期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 252, 期 -, 页码 203-210出版社
ELSEVIER
DOI: 10.1016/j.molliq.2017.12.084
关键词
Adsorption clearance; Uremic toxins; p-Cresol; Creatinine; Urea; Simulated serum
资金
- Chang Gung Medical Foundation, Taiwan [CMRPD2F0071]
In this study, five adsorbents including activated carbon (AC), three zeolites ZSM-5 with a molar ratio of SiO2 to Al2O3 of 23-400, and graphene oxide (GO) were selected to investigate their abilities for the clearance of three low molecular-weight uremic toxins (p-cresol, creatinine, and urea) from simulated serum at 37 degrees C. The physicochemical properties of the adsorbents were characterized using the X-ray powder diffractometer and porosimeter. It was found that the adsorption can be followed by the pseudo-second-order kinetic model and the Langmuir equation better fits all adsorption isotherms than the Freundlich equation under the conditions studied. Of the three adsorbents, ZSM5-400 (ZSM-5 with Si/AI = 400) has a maximum adsorption capacity for urea (0.70 mmol/g) and GO has a maximum adsorption capacity for p-cresol (4.01 mmol/g) and creatinine (1.01 mmol/g). To efficiently treat chronic kidney disease patients case by case, the adsorption isotherms of p-cresol and creatinine on the mixed adsorbents was experimentally and theoretically studied to evaluate the possibility of using tailor-made adsorbents. The cell viability of the selected adsorbents at different doses for fibroblast NIH/3T3 cells was finally examined. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据