期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 430, 期 12, 页码 1696-1713出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.04.018
关键词
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资金
- Fondation pour la Recherche Medicale (FRM) [DEQ20170336729]
- Societe Nationale Francaise de Gastro-enterologie (SNFGE)
- Association Francois Aupetit (AFA)
- [ANR-14-CE14-0022]
Autophagy refers to the conserved, multi-step mechanism that delivers cytosolic cargoes to vesicles of the endolysosomal system for degradation. It maintains cellular homeostasis by ensuring the continuous degradation of misformed/senescent intracellular components and the associated recycling of nutrients. Autophagy also represents an important cell-intrinsic defense mechanism against invasion by intracellular pathogens, including viruses. Autophagy might oppose viral invasion by targeting viral particles or viral components for degradation. It can also promote the interaction of viral constituents with receptors specialized in the activation of innate immunity pathways or facilitate the activation of anti-viral adaptive immunity. In response to such pressures, viruses have evolved various sophisticated strategies to avoid anti-viral autophagic responses or to manipulate the autophagic machinery to promote their own replication. This review focuses on our current knowledge of autophagy-related events that take place at early stages during interaction of viruses with host cells as well as on their associated consequences in terms of virus replication and cell fate. (C) 2018 Elsevier Ltd. All rights reserved.
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