Article
Cell Biology
Cansu Karakaya, Mark C. C. van Turnhout, Valery L. L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. M. Sahlgren, Sandra Loerakker
Summary: Mechanical stimuli and Notch signaling play important roles in regulating vascular growth and remodeling. This study reveals that cyclic strain decreases Notch signaling and leads to the loss of contractile features in vascular smooth muscle cells. Activation of Notch signaling partially rescues the contractile features of these cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Soumitra Mitra, Sulochana Devi, Mi-Sun Lee, Jonathan Jui, Aresh Sahu, Daniel Goldman
Summary: In the zebrafish retina, Muller glia can regenerate retinal neurons through a signaling pathway involving microglia/macrophages, Muller glia, and vascular endothelial cells. This pathway regulates gene expression, Notch signaling, proliferation, and neuronal regeneration in Muller glia. The interaction between Muller glia-derived Vegfaa and Pgfa and Flt1 and Kdrl receptors on vascular endothelial cells plays a crucial role in this process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Kathleen Zohorsky, Shigang Lin, Kibret Mequanint
Summary: The study demonstrated that utilizing bead-bound Jagged1 was effective in activating Notch3 and promoting SMC differentiation/maturation, while magnetic pulling forces did not activate Notch3 but instead provided necessary clustering or traction forces for Notch activation. The findings suggest that manipulation of Jagged1 presentation strategy can improve biomaterial-driven control of SMC behavior.
Article
Immunology
Te Jiang, Zhankui Li, Di Zhao, Bengang Hui, Zhiyuan Zheng
Summary: The study demonstrates that SOX18 modulates the proliferation and migration of airway smooth muscle cells induced by TNF-alpha by regulating the Notch1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Developmental Biology
Jennifer Kurz, Anna-Carina Weiss, Hauke Thiesler, Fairouz Qasrawi, Lena Deuper, Jaskiran Kaur, Carsten Rudat, Timo H. Luedtke, Irina Wojahn, Herbert Hildebrandt, Mark-Oliver Trowe, Andreas Kispert
Summary: The Notch signaling pathway plays an important role in regulating the expression of Myocd and a group of late SMC structural genes during visceral SMC differentiation in the ureter.
Review
Cell Biology
Abdellah Akil, Ana K. Gutierrez-Garcia, Rachael Guenter, J. Bart Rose, Adam W. Beck, Herbert Chen, Bin Ren
Summary: The Notch signaling pathway is crucial in determining the fate of vascular endothelial cells, angiogenesis, and tumor progression, particularly in the development of CSCs and therapeutic resistance. Cross-talk between Notch pathway and other signaling pathways plays a vital role in promoting various aspects of tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ting Wen, Yanyan Duan, Dan Gao, Xinxin Zhang, Xiaoyan Zhang, Liang Liang, Ziyan Yang, Peiran Zhang, Jiayulin Zhang, Jiaxing Sun, Yixuan Feng, Qijun Zheng, Hua Han, Xianchun Yan
Summary: This study aims to elucidate the regulation of Notch signaling in vascular smooth muscle cell phenotypic transition. The researchers found that miR-342-5p promotes vSMC-PT through a negative-feedback regulation of Notch signaling by downregulating FOXO3. In a simulated tumor microenvironment, miR-342-5p was upregulated by tumor cell-derived conditional medium and its blockade abrogated vSMC-PT induced by the medium. These findings suggest that miR-342-5p could be a potential target for cancer therapy.
Article
Biochemistry & Molecular Biology
Shuji Matsuguchi, Yohei Hirai
Summary: Pluripotent stem cells have the capacity to differentiate into all three germ layers. However, when stemness factors are removed, pluripotent stem cells, such as embryonic stem cells (ESCs), exhibit EMT-like behavior and lose stemness signatures. This process involves the membrane translocation of syntaxin4 (Stx4) and the expression of P-cadherin. Extracellular Stx4 induces upregulation of the gastrulation-related gene brachyury and slightly upregulates the smooth muscle cell-related gene ACTA2 in ESCs. Furthermore, extracellular Stx4 prevents the elimination of C/EBP13. These findings highlight the role of extracellular Stx4 in early mesoderm induction and its impact on differentiation state.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Alvaro Yogi, Marina Rukhlova, Claudie Charlebois, Ganghong Tian, Danica B. Stanimirovic, Maria J. Moreno
Summary: The study found that VSMCs differentiated from adipose-derived stem cells (ASCs) show potential for populating PET-based vascular scaffolds. By shortening the differentiation period and studying the role of downstream effectors of TGF-beta, the process was stabilized. The non-woven PET structure did not affect ASC differentiation, providing a novel alternative to address issues with long-term patency of vascular grafts.
Article
Engineering, Biomedical
Jiesi Luo, Yuyao Lin, Xiangyu Shi, Guangxin Li, Mehmet H. Kural, Christopher W. Anderson, Matthew W. Ellis, Muhammad Riaz, George Tellides, Laura E. Niklason, Yibing Qyang
Summary: Research successfully derived functional xenogeneic-free hiPSC-VSMCs by replacing animal-derived reagents with functional counterparts of human origin, and developed tissue rings with comparable mechanical strength. Engineered vascular tissues were generated by seeding XF-hiPSC-VSMCs onto biodegradable PGA scaffolds, suitable for implantation into an immunodeficient mice model.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Mojtaba Parvizi, Zachary C. Ryan, Sanam Ebtehaj, Bonnie K. Arendt, Ian R. Lanza
Summary: Research has shown that senescent preadipocytes can induce an inflammatory phenotype, decrease cell viability, disrupt proliferation and migration, affecting the occurrence of vascular diseases by triggering phenotypic and functional changes in key cellular components of blood vessels.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Developmental Biology
Arndt F. Siekmann
Summary: This review discusses the functions of vascular mural cells in blood vessel formation and diameter regulation, as well as their interactions with endothelial cells. It also introduces the signaling pathways controlling mural cell development and highlights distinguishing features of mural cells located on different types of blood vessels. Therapeutic strategies involving mural cells to improve tissue ischemia and vascular efficiency in various diseases are explored.
Article
Pharmacology & Pharmacy
Randa M. Breikaa, Kimberly Denman, Yukie Ueyama, Patricia E. McCallinhart, Aiman Q. Khan, Gunjan Agarwal, Aaron J. Trask, Vidu Garg, Brenda Lilly
Summary: This study reveals the essential role of Jag1 in adult endothelial cells in regulating and maintaining smooth muscle cell function in arterial vessels, partially through autoregulation of Notch signaling and influencing cell matrix/adhesion components in smooth muscle cells.
VASCULAR PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Mengcheng Shen, Thomas Quertermous, Michael P. Fischbein, Joseph C. Wu
Summary: The developmental origin of vascular smooth muscle cells plays a crucial role in regional susceptibility and resistance to vascular diseases. Patient induced pluripotent stem cell-derived VSMCs are valuable for research and therapeutic applications, but the heterogeneity in developmental origins poses challenges.
CIRCULATION RESEARCH
(2021)
Article
Hematology
Cheng Gao, Yi Fu, Yanhui Li, Xu Zhang, Lu Zhang, Fang Yu, Susanna S. Xu, Qingbo Xu, Yi Zhu, Youfei Guan, Xian Wang, Wei Kong
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Article
Hematology
Ying Liang, Yi Fu, Ruomei Qi, Meili Wang, Nan Yang, Li He, Fang Yu, Jian Zhang, Cai-Hong Yun, Xian Wang, Junling Liu, Wei Kong
Article
Cardiac & Cardiovascular Systems
Thorsten Kessler, Lu Zhang, Ziyi Liu, Xiaoke Yin, Yaqian Huang, Yingbao Wang, Manuel Mayr, Qing Ge, Qingbo Xu, Yi Zhu, Xian Wang, Kjestine Schmidt, Cor de Wit, Jeanette Erdmann, Heribert Schunkert, Zouhair Aherrahrou, Wei Kong
Article
Biochemistry & Molecular Biology
Meili Wang, Yi Fu, Cheng Gao, Yiting Jia, Yaqian Huang, Limei Liu, Xian Wang, Wengong Wang, Wei Kong
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Cardiac & Cardiovascular Systems
Yi Fu, Cheng Gao, Ying Liang, Meili Wang, Yaqian Huang, Wei Ma, Tuoyi Li, Yiting Jia, Fang Yu, Wanlin Zhu, Qinghua Cui, Yanhui Li, Qingbo Xu, Xian Wang, Wei Kong
CIRCULATION RESEARCH
(2016)
Article
Hematology
Li He, Yi Fu, Jingna Deng, Yicong Shen, Yingbao Wang, Fang Yu, Nan Xie, Zhongjiang Chen, Tianpei Hong, Xinjian Peng, Qingqing Li, Jing Zhou, Jingyan Han, Ying Wang, Jianzhong Xi, Wei Kong
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Cell Biology
Yiting Jia, Meili Wang, Chenfeng Mao, Fang Yu, Yingbao Wang, Rui Xiao, Changtao Jiang, Lemin Zheng, Qingbo Xu, Ming Zheng, Yi Fu, Qinghua Hu, Wei Kong
CELL DEATH & DISEASE
(2018)
Article
Multidisciplinary Sciences
Tuoyi Li, Bing Yu, Zhixin Liu, Jingyuan Li, Mingliang Ma, Yingbao Wang, Mingjiang Zhu, Huiyong Yin, Xiaofeng Wang, Yi Fu, Fang Yu, Xian Wang, Xiaohong Fang, Jinpeng Sun, Wei Kong
NATURE COMMUNICATIONS
(2018)
Article
Hematology
Yaoyao Du, Cheng Gao, Ziyi Liu, Li Wang, Bo Liu, Fan He, Tao Zhang, Yue Wang, Xiujie Wang, Mingjiang Xu, Guan-Zheng Luo, Yi Zhu, Qingbo Xu, Xian Wang, Wei Kong
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Ziyi Liu, Hongzhi Luo, Lu Zhang, Yaqian Huang, Bo Liu, Kongyang Ma, Juan Feng, Jinsheng Xie, Jingang Zheng, Jing Hu, Siyan Zhan, Yi Zhu, Qingbo Xu, Wei Kong, Xian Wang
CIRCULATION RESEARCH
(2012)
Article
Surgery
Biao Zhou, Wei Li, Guizhen Zhao, Bing Yu, Baihui Ma, Zhujiang Liu, Nan Xie, Yi Fu, Ze Gong, Rongbo Dai, Xiaoming Zhang, Wei Kong
JOURNAL OF VASCULAR SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Guizhen Zhao, Yi Fu, Zeyu Cai, Fang Yu, Ze Gong, Rongbo Dai, Yanhua Hu, Lingfang Zeng, Qingbo Xu, Wei Kong
CIRCULATION RESEARCH
(2017)
Article
Hematology
Bing Yu, Ziyi Liu, Yi Fu, Yingbao Wang, Lu Zhang, Zeyu Cai, Fang Yu, Xian Wang, Jun Zhou, Wei Kong
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)