期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 114, 期 -, 页码 141-149出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2017.11.010
关键词
Mammalian sterile 20-like kinase 1; Cardiovascular disorders; Apoptosis; Autophagy
资金
- National Natural Science Foundation of China [81370194, 81770224, 81670204, 81570318, 81500263]
- China Postdoctoral Science Foundation [2016T90973, 2015M572681]
Hippo signaling is a conserved pathway and plays important roles in controlling cell proliferation and differentiation. As a critical component of the Hippo pathway in mammals, mammalian sterile 20-like kinase 1 (MST1) participates in cell apoptosis and cell proliferation. Yes-associated protein (YAP) acts as a downstream transcriptional co-activator of MST1. MST1 is present in heart tissue and helps determine the fate of cardiomyocytes by regulating the balance between autophagy and apoptosis. Recent studies showed MST1 signaling is an essential participant in many cardiovascular disorders, including aortic dissection, aortic aneurysm, atherosclerosis, myocardial ischemic injury, and cardiomyopathy. Previous studies have summarized the roles of MST1 in cardiovascular development. In this review, we focused on the roles of MST1 signaling in cardiovascular disorders.
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