A DAP12-Dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12

(2013) Agnieszka Paradowska-Gorycka et al.   HUMAN IMMUNOLOGY

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke

(2013) Matthias W. Sieber et al.   PLoS One

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Using comparative anatomy in the axotomy model to identify distinct roles for microglia and astrocytes in synaptic stripping

(2012) Shozo Jinno et al.   Neuron Glia Biology

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

(2010) Mitsuyo Maeda et al.   GLIA

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin

(2009) Karel Otero et al.   NATURE IMMUNOLOGY

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

The formation of argpyrimidine, a methylglyoxal–arginine adduct, in the nucleus of neural cells

(2008) Yusuke Nakadate et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DAP10- and DAP12-associated receptors in innate immunity

(2008) Lewis L. Lanier   IMMUNOLOGICAL REVIEWS

G-Protein-Coupled Receptor Screen Reveals a Role for Chemokine Receptor CCR5 in Suppressing Microglial Neurotoxicity

(2008) K. Gamo et al.   JOURNAL OF NEUROSCIENCE

Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease

(2008) J. Cameron Thrash et al.   NEUROCHEMICAL RESEARCH