Article
Nutrition & Dietetics
Xin Guan, Qiyang Yan, Dandan Wang, Guocheng Du, Jingwen Zhou
Summary: This study investigates the effects of IGF-1 signaling on mitochondrial remodeling during myogenic differentiation, and identifies key mediators of IGF-1-induced mitochondrial biogenesis and mitophagy. IGF-1 signaling stimulates mitochondrial biogenesis by increasing mitochondrial DNA copy number and the expression of related genes. Additionally, IGF-1 treatment significantly enhances mitophagy levels in differentiating myoblasts, contributing to mitochondrial turnover.
Article
Pathology
Shunsuke Iriyama, Saori Nishikawa, Junichi Hosoi, Satoshi Amano
Summary: This study demonstrates the influence of basement membrane (BM) integrity on the level of hyaluronan (HA) in the epidermis, showing that BM structure impairment in sun-exposed skin of older subjects is associated with decreased epidermal HA content. In experimental models, inhibitors of BM-degrading matrix metalloproteinases and heparanase lead to increased epidermal HA levels, highlighting the importance of BM in maintaining epidermal HA levels.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell & Tissue Engineering
Jingting Li, Manisha Tiwari, Yifang Chen, Sudjit Luanpitpong, George L. Sen
Summary: Proper differentiation of the epidermis is crucial for preventing water loss and protecting against the external environment. CDK12 plays a key role in epidermal differentiation.
Article
Endocrinology & Metabolism
Lingjie Sang, Huai-qiang Ju, Zuozhen Yang, Qiwei Ge, Zhen Zhang, Fangzhou Liu, Luojia Yang, Hangdi Gong, Chengyu Shi, Lei Qu, Hui Chen, Minjie Wu, Hao Chen, Ruihua Li, Qianqian Zhuang, Hailong Piao, Qingfeng Yan, Weishi Yu, Liangjing Wang, Jianzhong Shao, Jian Liu, Wenqi Wang, Tianhua Zhou, Aifu Lin
Summary: The research found that long non-coding RNAs play a crucial role in regulating cellular processes, with lncRNA GAS5 identified as a regulator of tricarboxylic acid cycle enzymes during nutrient stress. By annotating and studying the subcellular distribution of organelle-associated lncRNAs, it revealed their functional role in cellular metabolic homeostasis.
Article
Biochemistry & Molecular Biology
Xuehua Li, Jacob Kordsmeier, Intawat Nookaew, Ha-Neui Kim, Jinhu Xiong
Summary: In this study, the researchers found that the mechanically sensitive ion channel Piezo1 plays a critical role in mitochondrial adaptation to mechanical stimulation. They also discovered that cAMP signaling contributes to the increase in mitochondrial oxidative phosphorylation (OXPHOS) induced by activation of Piezo1.
Article
Cell Biology
Dzmitry Mukha, Mariam Fokra, Alona Feldman, Boris Sarvin, Nikita Sarvin, Keren Nevo-Dinur, Elazar Besser, Elior Hallo, Elina Aizenshtein, Zachary T. Schug, Tomer Shlomi
Summary: This study reveals the high flux of GCS in hepatocellular carcinoma, which not only supports nucleotide biosynthesis but also plays a crucial role in maintaining protein lipoylation and mitochondrial activity.
Article
Biotechnology & Applied Microbiology
Minmin Yang, Bowen Hu, Donglei Sun, Changbin Zhao, Haohui Wei, Dajian Li, Zhiying Liang, Yongxia Zhao, Jinping Liang, Meiqing Shi, Qingbin Luo, Qinghua Nie, Xiquan Zhang, Dexiang Zhang, Hongmei Li
Summary: This study demonstrates that GHR promotes mitochondrial function and inhibits lipid peroxidation as well as fat deposition in chickens, and it is essential for maintaining the stability of lipid metabolism and regulating mitochondrial function.
Article
Cell Biology
Lulu Zhang, Xubiao Wei, Zhimeng Wang, Peiyuan Liu, Yanfei Hou, Yifang Xu, Huili Su, Matthew D. Koci, Hang Yin, Conggang Zhang
Summary: NF-KB pathway activation enhances STING signaling by regulating microtubule-mediated STING trafficking, leading to robust host antiviral defense and amplified interferon response.
Article
Immunology
Leah K. Billingham, Joshua S. Stoolman, Karthik Vasan, Arianne E. Rodriguez, Taylor A. Poor, Marten Szibor, Howard T. Jacobs, Colleen R. Reczek, Aida Rashidi, Peng Zhang, Jason Miska, Navdeep S. Chandel
Summary: The study found that inhibitors of different complexes in the mitochondrial electron transport chain (ETC) can prevent the activation of the NLRP3 inflammasome, and the expression of specific enzymes from yeast or tunicates can rescue the activation of NLRP3 inflammasome in the absence of functional mitochondrial complex I or III. Metabolomics revealed that ATP generation through the phosphocreatine-dependent mechanism sustains the activation of NLRP3 inflammasome.
Article
Multidisciplinary Sciences
David Matye, Sumedha Gunewardena, Jianglei Chen, Huaiwen Wang, Yifeng Wang, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Yanhong Du, Cheng Chen, Jacob E. Friedman, Shelly C. Lu, Wen-Xing Ding, Tiangang Li
Summary: Matye et al. found that deficiency of coenzyme-A and glutathione in NAFLD leads to impaired fatty acid oxidation and antioxidant defense. They also discovered that fatty liver is a sulfur amino acid insufficient state, which limits coenzyme-A availability and promotes metabolic inflexibility.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Non Miyata, Takanori Ito, Miyu Nakashima, Satoru Fujii, Osamu Kuge
Summary: The Ups2-Mdm35 complex plays an important role in mitochondrial energy metabolism and cell quiescence entry through its involvement in phospholipid synthesis. Depletion of Ups2 leads to overactivation of the yeast AMPK homolog Snf1, which in turn affects mitochondrial ATP production and cell quiescence entry. Additionally, depletion of Ups2 in yeast results in synthetic growth defects when combined with the cell-cycle regulators Whi5 and Whi7, similar to the functional orthologs of the tumor suppressor Rb1. Knockdown of the human homolog of Ups2, PRELID3b, also reduces the viability of Rb1-deficient breast cancer cells, suggesting its potential as a target for cancer therapy.
Article
Biochemistry & Molecular Biology
Ana Vujic, Amy N. M. Koo, Hiran A. Prag, Thomas Krieg
Summary: Mitochondria play a crucial role in cellular processes and heart function, with communication between mitochondria and the nucleus maintaining cardiomyocyte homeostasis. Excessive generation of ROS can lead to irreversible cell damage, contributing to various pathologies. Additionally, myocardial impairments are associated with specific metabolic changes and dysregulated inflammatory responses.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Microbiology
Suelen Queiroz Diniz, Andrea Teixeira-Carvalho, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Bruno Coelho Rocha, Olindo Assis Martins-Filho, A. Ricardo Goncalves, Dhelio Batista Pereira, Mauro Shugiro Tada, Fabiano Oliveira, Ricardo Tostes Gazzinelli, Lis Ribeiro do Valle Antonelli
Summary: Monocytes play a crucial role in host defense against Plasmodium vivax by producing inflammatory cytokines and mitochondrial reactive oxygen species (mROS). During human P. vivax malaria, monocyte metabolism is altered, with mitochondria playing a key role in this change. This metabolic reprogramming leads to an increase in mROS production, contributing to protective responses against P. vivax and potentially triggering immunomodulatory mechanisms.
Article
Multidisciplinary Sciences
Wonyul Jang, Dmytro Puchkov, Paula Samso, YongTian Liang, Michal Nadler-Holly, Stephan J. Sigrist, Ulrich Kintscher, Fan Liu, Kamel Mamchaoui, Vincent Mouly, Volker Haucke
Summary: Cells respond to fluctuating nutrient supply by changing organelle dynamics and metabolism. This study reveals that lipid signaling on the endoplasmic reticulum can control mitochondrial morphology and function, enabling cells to adapt to changing nutrient environments.
Review
Biochemistry & Molecular Biology
Laura A. Orofiamma, Dafne Vural, Costin N. Antonescu
Summary: This article reviews the mechanisms by which EGFR regulates cell metabolism and discusses how EGFR-driven control of metabolism can impact cell proliferation, differentiation, and certain diseases and therapy outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Meeting Abstract
Dermatology
C. Monteleon, T. Agnihotri, A. Dahal, M. Liu, V. Rebecca, G. Beatty, R. Amavaradi, T. Ridky
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tarub S. Mabud, Yuli Zhu, Phillip L. Guichet, Tanvir Agnihotri, Bhavin Patel, Lea Azour, Bedros Taslakian, Stuart Garay, William Moore
Summary: The study evaluated the ablation zone sizes in patients who underwent pulmonary tumor cryoablation with 14-gauge cryoablation probes. The results showed that the ablation volumes generated by 14-gauge probes were larger than those generated by 17-gauge probes, and the manufacturer-reported isotherms were significantly larger than the actual ablation zones. Cryoablation can achieve low rates of local recurrence.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)