Astragaloside IV ameliorates early diabetic nephropathy by inhibition of MEK1/2-ERK1/2-RSK2 signaling in streptozotocin-induced diabetic mice

Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment

(2018) Lin Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/β-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling

(2018) Ming Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation

(2018) Hua Chen et al.   PHYTOMEDICINE

Combined Clinical Phenotype and Lipidomic Analysis Reveals the Impact of Chronic Kidney Disease on Lipid Metabolism

(2017) Hua Chen et al.   JOURNAL OF PROTEOME RESEARCH

Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway

(2017) Ming Wang et al.   PHYTOMEDICINE

Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus : A review

(2016) Hua Chen et al.   FITOTERAPIA

Astragaloside IV ameliorates renal injury in db/db mice

(2016) Huili Sun et al.   Scientific Reports

Astragaloside IV suppresses transforming growth factor-β1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-κB signaling pathways

(2015) Xiajing Che et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTEN Regulates Renal Extracellular Matrix Deposit via Increased CTGF in Diabetes Mellitus

(2015) Lin Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Extracellular superoxide dismutase ameliorates streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling

(2015) Chia-Wen Kuo et al.   LIFE SCIENCES

Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress

(2015) Zeng Si Wang et al.   BMC Nephrology

Metabolomics insights into chronic kidney disease and modulatory effect of rhubarb against tubulointerstitial fibrosis

(2015) Zhi-Hao Zhang et al.   Scientific Reports

Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis and Nrf2 dysfunction in aristolochic acid-induced nephropathy

(2015) Ying-Yong Zhao et al.   Scientific Reports

Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats

(2014) Jianguo Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro

(2014) Li Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review

(2014) Ting Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective Effects of Astragaloside IV on db/db Mice with Diabetic Retinopathy

(2014) Yuzhi Ding et al.   PLoS One

Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells

(2014) Qin Wang et al.   RENAL FAILURE

Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways

(2013) Dingkun Gui et al.   APOPTOSIS

Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells

(2013) Weiwei Qi et al.   CELL STRESS & CHAPERONES

Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression

(2013) Dingkun Gui et al.   CYTOKINE

Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats

(2013) Huili Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: A review

(2013) Ying-Yong Zhao   JOURNAL OF ETHNOPHARMACOLOGY

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

(2012) Mona Sedeek et al.   CLINICAL SCIENCE

Diabetic Nephropathy and Extracellular Matrix

(2012) S. O. Kolset et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Astragaloside IV Attenuates Complement Membranous Attack Complex Induced Podocyte Injury Through the MAPK Pathway

(2011) Rong Zheng et al.   PHYTOTHERAPY RESEARCH

Potential New Therapeutic Agents for Diabetic Kidney Disease

(2010) Faruk Turgut et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase

(2010) Vishal S. Vaidya et al.   KIDNEY INTERNATIONAL

Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-β signaling

(2010) J. Li et al.   PHYTOMEDICINE

Prevention of Diabetic Kidney Disease: Negative Clinical Trials With Renin-Angiotensin System Inhibitors

(2009) Robert G. Nelson et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Roles of mitogen-activated protein kinases and angiotensin II in renal development

(2009) A.P.C. Balbi et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH