期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 182, 期 -, 页码 194-199出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2018.02.004
关键词
Ru(II) arene complexes; 18 beta-Glycyrrhetinic acid; Anticancer
资金
- Key International (Regional) Joint Research Program of NSF [21420102002]
- NSFC [21401105, 21778033, 21601088, 21771109]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Summit of the Six Top Talents Program of Jiangsu Province
- Natural Science Foundation of the Jiangsu Province [BE2013716, BK20171472]
- Biomedical and Functional Materials of National and Local Joint Engineering Center (Jiangsu)
- 333 talent project Program of Jiangsu Province
Metal-arene complexes containing bioactive natural-product derived ligands can have new and unusual properties. We report the synthesis, characterization and antiproliferative activity of two new Ru(II) arene complexes with imidazole (dichlorido complex 1) or bipyridyl (chlorido complex 2) ligands conjugated to 18 beta-glycyrrhetinic acid, an active triterpenoid metabolite of Glycyrrhiza glabra. In general, the conjugated ligands and complexes showed only moderate activity against HeLa (cervical), MCF-7 (breast) and A2780 (ovarian) cancer cells, although the activity of complex 2 in the former two cell lines approached that of the drug cisplatin. Complex 2 (in contrast to complex 1) also exhibited significant activity towards both Gram-positive S. aureus and Gram-negative E. coil bacteria. Complex 2 can induce condensation of DNA and enhances the generation of intracellular reactive oxygen species (ROS). The conjugation of natural products to ligands in organometallic half-sandwich complexes provides a strategy to enhance their biological activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据