Article
Cell Biology
Niina Bhattarai, Eveliina Korhonen, Yashavanthi Mysore, Kai Kaarniranta, Anu Kauppinen
Summary: The study demonstrates that hydroquinone induces DNA damage and NLRP3-independent IL-18 secretion in human RPE cells.
Article
Pharmacology & Pharmacy
Judith Bockstiegel, Silas L. Wurnig, Jonas Engelhardt, Jana Enns, Finn K. Hansen, Guenther Weindl
Summary: The deficiency of HDAC6 does not affect the release of IL-1β mediated by NLRP3 in human immune cells, indicating that the inhibition of HDAC6 is not necessary for the function of the NLRP3 pathway. In addition, HDAC6 inhibitors have the potential to suppress inflammatory responses and inhibit the release of IL-1β by regulating Toll-like receptor (TLR) signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Ying-Yin Chao, Alisa Puhach, David Frieser, Mahima Arunkumar, Laurens Lehner, Thomas Seeholzer, Albert Garcia-Lopez, Marlot van der Wal, Silvia Fibi-Smetana, Axel Dietschmann, Thomas Sommermann, Tamara Cikovic, Leila Taher, Mark S. Gresnigt, Sebastiaan J. Vastert, Femke van Wijk, Gianni Panagiotou, Daniel Krappmann, Olaf Gross, Christina E. Zielinski
Summary: In this study, it was discovered that human T cells express GSDME, which is associated with durable viability and the release of IL-1 alpha. This property is only present in a subset of human helper type 17 T cells with specificity for Candida albicans, regulated by the T cell-intrinsic NLRP3 inflammasome. The release of IL-1 alpha is mediated by a proteolytic cascade involving caspase-8, caspase-3, and GSDME cleavage, as well as T cell receptor stimulation and calcium-licensed calpain maturation of pro-IL-1 alpha form. This finding expands our understanding of the functional diversity and mechanism of T cells and has implications for antifungal immunity.
Article
Immunology
Ewa Oleszycka, Eoin C. OBrien, Michael Freeley, Ed C. Lavelle, Aideen Long
Summary: Bile acids, synthesized from cholesterol, play a role in promoting intestinal absorption and have been associated with inflammatory diseases. This study demonstrates that bile acids can induce the secretion of pro-inflammatory cytokines and the recruitment of innate immune cells, suggesting their mechanistic role in inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
S. Leng, W. Xu, L. Wu, L. Liu, J. Du, F. Yang, D. Huang, L. Zhang
Summary: Apical periodontitis is an inflammatory condition caused by immunological reaction to invading bacteria. NLRP3 plays a crucial role in the pathogenesis of this condition by disturbing the balance between Treg and Th17 cells. The dysregulation of NLRP3 exacerbates periapical inflammation and bone resorption.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Immunology
Kaveh Abdi, Karen Laky, Mehrnoosh Abshari, Elizabeth M. Hill, Larry Lantz, Nevil J. Singh, Eric O. Long
Summary: It has been found that NK cells produce IFN-gamma before the production of IL-12 by DCs in the early stage of immune response. Toll-like Receptor 4 (TLR4) on DCs and soluble factors produced by LPS-activated DCs play important roles in IFN-gamma production by NK cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Hung Le, Paul Spearman, Stephen N. Waggoner, Karnail Singh
Summary: Accumulation of activated NK cells in tissues during Ebola virus infection contributes to EVD pathogenesis. Immunization with Ebola VLPs provides rapid, NK cell-mediated protection against Ebola challenge. VP40 protein stimulates NK cell functions in an IL-12- and IL-18-dependent manner involving CD14(+) and CD14(-) accessory cells.
Article
Oncology
Qinqin Liu, Mingqiang Hua, Chen Zhang, Ruiqing Wang, Jinting Liu, Xinyu Yang, Fengjiao Han, Ming Hou, Daoxin Ma
Summary: The bone marrow microenvironment in AML patients exhibits immunosuppressive features, and NLRP3-activated BMDCs are found to promote the differentiation of Th1 cells while inhibiting leukemia cell proliferation. This study sheds light on potential immunotherapeutic strategies for AML patients.
Editorial Material
Immunology
Joanna R. Groom, James E. Vince
Summary: A T(H)17 cell NLRP3-caspase-8-caspase-3-GSDME axis is found to release the alarmin IL-1 alpha without inducing cell death.
Article
Biochemistry & Molecular Biology
Dora Bencze, Tunde Fekete, Walter Pfliegler, Arpad Szoor, Eszter Csoma, Antonia Szanto, Tunde Tarr, Attila Bacsi, Lajos Kemeny, Zoltan Vereb, Kitti Pazmandi
Summary: The study reveals the presence of the NLRP3-dependent IL-1β secretory pathway in pDCs, which only prevails under non-dominant inflammatory conditions. The type I interferon pathway and IL-1β pathway interact with each other, with interferon inhibiting IL-1β production in pDCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, Kazuomi Kario, Masafumi Takahashi
Summary: Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. The NLRP3 inflammasome plays a critical role in the pathophysiology of SCM, with the activation of IL-1 beta and IL-18 contributing to the development of SCM.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Immunology
Magdalena Kowalewicz-Kulbat, Piotr Szpakowski, Krzysztof T. Krawczyk, Marek L. Kowalski, Slawomir Kosinski, Franck Biet, Wieslawa Rudnicka, Camille Locht
Summary: The Bacillus Calmette-Guerin (BCG) vaccine, along with recombinant BCG strains producing IL-18, have been shown to potentially protect against unrelated diseases like allergic asthma. Studies have demonstrated that these vaccines can induce the maturation of dendritic cells and decrease exaggerated Th2 responses in allergic asthma patients.
Review
Neurosciences
Jingjing Wang, Yuxiao Gao, Yujia Yuan, Huan Wang, Zhao Wang, Xiangjian Zhang
Summary: This paper reviews the mechanism of action of Th17 cells and IL-17A in ischemic stroke and the progress of research on targeted therapy.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mathias Busch, Gerrit Bredeck, Friedrich Waag, Khosrow Rahimi, Haribaskar Ramachandran, Tobias Bessel, Stephan Barcikowski, Andreas Herrmann, Andrea Rossi, Roel P. F. Schins
Summary: Due to the widespread presence of environmental MNPs, inhalation and ingestion by humans is highly likely, but the health effects remain largely unknown. This study established THP-1 cells with or without NLRP3 to investigate the potential of MNPs to activate the NLRP3 inflammasome. The results suggest that most MNPS do not directly activate the NLRP3 inflammasome, but specific MNP types may still possess pro-inflammatory potential.
Article
Immunology
Shuai Qiao, Xiangrui Zhang, Ziyi Chen, Ye Zhao, Chi-Meng Tzeng
Summary: This study demonstrates the effectiveness of alloferon-1 in preventing estrogen deficiency-induced osteoporosis. It restores bone density and microstructure, affects biochemical markers of bone turnover, and suppresses the expression of inflammatory cytokines in bone tissues. These findings suggest that alloferon-1 could be a potential alternative drug or auxiliary modulator for the treatment of postmenopausal osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Livia Viana de Castro Reis, Karina Magna Macena Leao, Ana Paula Badan Ribeiro, Marcelo Bispo de Jesus, Gabriela Alves Macedo, Juliana Alves Macedo
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2020)
Article
Nanoscience & Nanotechnology
Luiz A. B. Ferreira, Samara Bonesso dos Reis, Emanueli do Nascimento da Silva, Solange Cadore, Juliana da Silva Bernardes, Nelson Duran, Marcelo B. de Jesus
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Toxicology
Fabio Bucaretchi, Carla F. Borrasca-Fernandes, Camila C. Prado, Rafael Lanaro, Jose Luiz Costa, Otavio M. Petroni, Tiago Giraldi, Maria Heloisa S. L. Blotta, Amauri S. Justo-Junior, Natalia L. Sousa, Francisco J. L. Aragao, Eduardo M. De Capitani, Stephen Hyslop
Summary: This case report describes a near-fatal poisoning due to intentional injection of ricin, resulting in septic shock-like syndrome, multiple organ dysfunction, and necrotizing fasciitis. The patient was successfully treated with supportive care, leading to gradual improvement and discharge on day 71 with limited range of motion and function of the left forearm and hand.
CLINICAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Samara Bonesso dos Reis, Juliana de Oliveira Silva, Fernanda Garcia-Fossa, Elaine Amaral Leite, Angelo Malachias, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira, Monica Cristina Oliveira, Andre Luis Branco de Barros, Marcelo Bispo de Jesus
Summary: pH-sensitive liposomes showed fast accumulation and intracellular release of doxorubicin in tumor cells, leading to apoptosis. The cytotoxicity of pH-sensitive liposomes can be enhanced by chloroquine and E64d.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Infectious Diseases
Livia Furquim de Castro, Kamila de Araujo Mathias, Julia Vieira Nunes, Ana Lucia Bergamasco Galastri, Dennis Henrique Leandro da Silva, Larissa Nara Alegrini Longhi, Maria Heloisa de Souza Lima Blotta, Ronei Luciano Mamoni
Summary: Exposure to ethanol impairs the effector functions of macrophages, possibly leading to polarization of M2 macrophages and affecting the development of adaptive response, resulting in decreased frequency of specific cell populations.
Article
Oncology
Tamires dos Santos, Livia Furquim de Castro
Summary: The study demonstrates that using a portable UV-C light device for disinfection of various microorganisms in hospitals is effective, achieving 100% bacterial inactivation rate and significant reduction in yeast colony counts.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Microbiology
Lilian de O. Coser, Livia M. Genaro, Amauri S. Justo-Junior, Plinio Trabasso, Ricardo M. Pereira, Luciana P. Ruas, Maria H. S. L. Blotta
Summary: The study found that the frequency of CD8(+) T cell subsets differs between patients with acute and chronic forms of paracoccidioidomycosis, but they may respond similarly to Paracoccidioides brasiliensis infection.
FUTURE MICROBIOLOGY
(2021)
Article
Food Science & Technology
Penelope Lacrisio Reis Menta, Maria Emilia Rabelo Andrade, Livia Furquim de Castro, Luisa Martins Trindade, Melissa Tainan Silva Dias, Josiane Erica Miyamoto, Raisa Magno dos Santos, Geovanni Dantas Cassali, Raquel Franco Leal, Ana Paula Badan Ribeiro, Renato Grimaldi, Leticia Martins Ignacio-Souza, Marcio Alberto Torsoni, Adriana Souza Torsoni, Valbert Nascimento Cardoso, Marciane Milanski
Summary: The study suggests that adding interesterified fat to a normal lipid diet may have adverse effects on intestinal mucosa, leading to increased intestinal permeability, bacterial translocation, and damage to the intestinal epithelium.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cell & Tissue Engineering
Leticia Queiroz da Silva, Amauri da Silva Justo-Junior, Beatriz de Moraes Martinelli, Marcio Alves da Cruz, Stephany Cares Huber, Silmara Aparecida de Lima Montalvao, Luiz Henrique de Freitas Filho, Cristina Pontes Vicente, Joyce Maria Annichino-Bizzacchi
Summary: This study evaluated the effect of lyophilized PRP on atherosclerosis in mice models and found that PRP could modulate inflammatory patterns.
REGENERATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
G. Perez Jorge, D. G. Modolo, Y. P. Jaimes-Florez, W. J. Favaro, M. B. de Jesus, M. Brocchi
Summary: In this study, an attenuated strain of Salmonella enterica Typhimurium, chi 11218, was used as a vector to deliver p53 to human bladder carcinoma cells, resulting in the restoration of wild-type p53 protein function. The study demonstrated that p53 delivered by chi 11218 significantly decreased the viability of human bladder cancer cells in a dose-dependent manner.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Biophysics
Thais Moraes-Lacerda, Marcelo Bispo de Jesus
Summary: Solid lipid nanoparticles (SLN) are widely used in various fields and show promising results in delivering biomolecules. However, the potential cytotoxic effects of SLN have been overlooked, and there is a lack of research in this area. This critical review emphasizes the importance of testing the biocompatibility and cytotoxicity of empty SLN and calls for further investigation on SLN toxicity, particularly in biomedical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Louise Lacalendola Tundisi, Janaina Artem Ataide, Juliana Souza Ribeiro Costa, Diego de Freitas Coelho, Raquel Bester Liszbinski, Andre Moreni Lopes, Laura Oliveira-Nascimento, Marcelo Bispo de Jesus, Angela Faustino Jozala, Carsten Ehrhardt, Priscila Gava Mazzola
Summary: Nanocarriers have the potential to overcome the challenges in drug delivery by targeting specific organs or cells and using nanotechnology to manipulate materials and control their properties. However, careful consideration is needed in choosing the delivery system, taking into account factors such as loading efficiency, physicochemical properties, production conditions, toxicity, and regulations. Moving from the laboratory to clinical applications and addressing toxicological issues are the major obstacles in the field of nanomedicine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Paulo H. Jr Jr Olivieri, Marcelo B. Jesus, Helena B. Nader, Giselle Z. Justo, Alioscka A. Sousa
Summary: This study reveals that surface glycosaminoglycans (GAGs) can regulate the cellular internalization of nanoparticles. Anionic nanoparticles are hindered by the charged surface GAGs, while cationic nanoparticles interact favorably with GAGs. Further investigation shows that the interaction of nanoparticles with GAGs is different, and heparan sulfate plays a crucial role in the cellular internalization of cationic nanoparticles.
Article
Pharmacology & Pharmacy
Vanessa Ortega, Allan Radaic, Marcelo Bispo de Jesus, Eneida de Paula, Selma Giorgio
Summary: Liposomal AME is a promising delivery system for treating visceral leishmaniasis, improving meglumine efficacy against L. infantum and minimizing its cytotoxicity towards canine macrophages.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jeanifer Caverzan, Marcelo B. de Jesus, Nelson Duran
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2020)
