期刊
JOURNAL OF INFECTION
卷 77, 期 3, 页码 212-219出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2018.03.014
关键词
Dengue; autoimmune disease; Pathogenesis; Epidemiology
资金
- Ministry of Health and Welfare, Taiwan [MOHW107-TDU-B-212-123004]
- China Medical University Hospital [DMR-107-192]
- Academia Sinica Stroke Biosignature Project [BM10701010021]
- MOST Clinical Trial Consortium for Stroke [MOST 106-2321-B-039-005-]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- Katsuzo and Kiyo Aoshima Memorial Funds, Japan
Objective: To investigate the risk of autoimmune diseases in dengue patients. Methods: We conducted a population-based cohort study by the Taiwan National Health Insurance Research Database, including a total of 12,506 newly diagnosed dengue patients and 112,554 control subjects between 2000 and 2010, matched by gender, age, income, urbanization, and comorbidities. Both cohorts were followed for a 3-year period to examine the incidence of autoimmune diseases. A Cox proportional hazards regression analysis was applied to calculate the risk of autoimmune diseases between both groups. Results: The dengue group showed an overall increased risk for 21 autoimmune diseases, with an adjusted hazard ratio (aHR) of 1.88 (95% confidence interval [CI], 1.4-2.37, p < 0.001). Compared with the control group, the dengue group had higher risks of Reiter's syndrome (aHR 14.03, 95 % CI 1.63-120.58), multiple sclerosis (aHR 11.57, 95 % CI 1.8-74.4), myasthenia gravis (aHR 5.35, 95 % CI 1.43-20.02), autoimmune encephalomyelitis (aHR 3.8, 95% CI 1.85-7.8), systemic vasculitis (aHR 3.7, 95 % CI 1.11-12.28), systemic lupus erythematosus (aHR 3.5, 95% CI 1.85-6.63), and primary adrenocortical insufficiency (aHR 2.05, 95% CI 1.25-3.35). Conclusion: Dengue patients were associated with an increased risk of autoimmune diseases. (C) 2018 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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