C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells

Munc13 proteins control regulated exocytosis in mast cells

(2017) Elsa M. Rodarte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion

(2015) M. C. Chicka et al.   BIOCHEMICAL JOURNAL

Phospholipase Cη2 Activation Redirects Vesicle Trafficking by Regulating F-actin

(2015) Masaki Yamaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis

(2015) N.-R. Bin et al.   JOURNAL OF CELL SCIENCE

Munc13-4 Regulates Granule Secretion in Human Neutrophils

(2014) C. Pivot-Pajot et al.   JOURNAL OF IMMUNOLOGY

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Munc18-2 and Syntaxin 3 Control Distinct Essential Steps in Mast Cell Degranulation

(2013) C. Brochetta et al.   JOURNAL OF IMMUNOLOGY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Exocyst Sec5 Regulates Exocytosis of Newcomer Insulin Granules Underlying Biphasic Insulin Secretion

(2013) Li Xie et al.   PLoS One

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation

(2013) N.-R. Bin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

(2012) Kristin L. Boswell et al.   JOURNAL OF CELL BIOLOGY

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane

(2011) E. D. Elstak et al.   BLOOD

SNARE complex-mediated degranulation in mast cells

(2011) Joseph R. Woska et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Syntaxin7 Is Required for Lytic Granule Release from Cytotoxic T Lymphocytes

(2011) Varsha Pattu et al.   TRAFFIC

Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis type 5 patients with mutations in STXBP2

(2010) M. Meeths et al.   BLOOD

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective

(2010) Nicolas Guex et al.   ELECTROPHORESIS

The Exocytosis of Lytic Granules Is Impaired in Vti1b- or Vamp8-Deficient CTL Leading to a Reduced Cytotoxic Activity following Antigen-Specific Activation

(2010) R. Dressel et al.   JOURNAL OF IMMUNOLOGY

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

(2010) V. Cetica et al.   JOURNAL OF MEDICAL GENETICS

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

(2009) S. M. Wood et al.   BLOOD

FcεRI-mediated mast cell migration: Signaling pathways and dependence on cytosolic free Ca2+ concentration

(2009) In Duk Jung et al.   CELLULAR SIGNALLING

Natural killer cell cytotoxicity: how do they pull the trigger?

(2009) Nicola J. Topham et al.   IMMUNOLOGY

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

(2009) O.-H. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-linking of FcɛRI causes Ca2+ mobilization via a sphingosine kinase pathway in a clathrin-dependent manner

(2008) Seung-Duk Ryu et al.   CELL CALCIUM

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH

Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain

(2004) Yuan Cheng et al.   PROTEIN SCIENCE