Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling

(2017) Miaomiao Lu et al.   Biomed Research International

Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction

(2016) Antoinette Bugyei-Twum et al.   Scientific Reports

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation

(2015) Ji-Won Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2015) Zizhen Gong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Curcumin, a component of golden spice: From bedside to bench and back

(2014) Sahdeo Prasad et al.   BIOTECHNOLOGY ADVANCES

Curcumin attenuates carcinogenesis by down regulating proinflammatory cytokine interleukin-1 (IL-1α and IL-1β) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice

(2014) Laxmidhar Das et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

(2014) Hiroe Honda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation

(2013) Yue Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders

(2013) Elisa Benetti et al.   MEDIATORS OF INFLAMMATION

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Cytotoxic Effects of Curcumin in Human Retinal Pigment Epithelial Cells

(2013) Margrit Hollborn et al.   PLoS One

Curcumin-From Molecule to Biological Function

(2012) Tuba Esatbeyoglu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage

(2012) Jing Han et al.   Autophagy

Curcumin in inflammatory diseases

(2012) Adeeb Shehzad et al.   BIOFACTORS

Curcumin uptake and metabolism

(2012) Manfred Metzler et al.   BIOFACTORS

The Targets of Curcumin

(2012) Hongyu Zhou et al.   CURRENT DRUG TARGETS

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Dietary Regulation of Histone Acetylases and Deacetylases for the Prevention of Metabolic Diseases

(2012) Tho Pham et al.   Nutrients

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Systemic Blockade of TNF-α does not Improve Insulin Resistance in Humans

(2011) I. Ferraz-Amaro et al.   HORMONE AND METABOLIC RESEARCH

Curcumin Recognizes a Unique Binding Site of Tubulin

(2011) Soumyananda Chakraborti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Linking the inflammasome to obesity-related disease

(2011) Tiffany Horng et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

(2010) Atsushi Tanaka   FEBS LETTERS

Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin

(2010) Markus Griesser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE