Article
Biochemistry & Molecular Biology
Xiufang Cui, Ziping Ye, Di Wang, Yan Yang, ChunHua Jiao, Jingjing Ma, Nana Tang, Hongjie Zhang
Summary: This study found that activation of AhR in DCs can induce tolerogenic DCs, promote Treg cell differentiation, and alleviate the severity of intestinal inflammation. Transplanted tolDCs can also maintain the balance of Th17/Treg differentiation. Therefore, AhR may be a potential therapeutic target for CD.
CELL AND BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Tae Woo Kim, Yujin Kim, Wonsik Jung, Dong Eon Kim, Hyeongseop Keum, Youngju Son, Sangyong Jon
Summary: BRNPs have shown potential in delaying disease onset, suppressing disease progression and severity, and reducing disease incidence rate in the EAE mouse model, without the need for systemic immunosuppression. Studies have found that BRNPs negatively regulate the differentiation of naive CD4(+) T cells into Th17 cells by scavenging reactive oxygen species.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Min Zou, Fang-jun Chen, Li-rong Deng, Qian Han, Chang-yin Huang, Shi-shi Shen, Brian Tomlinson, Yan-hong Li
Summary: Anemoside B4 (AB4) demonstrated significant preventive and therapeutic effects on experimental autoimmune encephalomyelitis (EAE) by modulating inflammatory responses and the gut microbiota, indicating its potential as a therapeutic agent for treating multiple sclerosis (MS).
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Shin-Young Na, Gurumoorthy Krishnamoorthy
Summary: The study demonstrates that ectopic expression of MOG in immune organs can induce MOG-specific tolerance and long-lasting protection, potentially serving as a therapeutic strategy for specific autoantigen-driven autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yahya Jand, Mohammad Hossein Ghahremani, Amir Ghanbari, Shahram Ejtemaei-Mehr, Gilles J. Guillemin, Mahmoud Ghazi-Khansari
Summary: Research has found that melatonin (MT) can improve clinical symptoms in the EAE model by modulating the kynurenine pathway (KP), reducing EAE clinical scores and the number of demyelinating plaques. MT treatment also decreases the mRNA expression of KP regulatory enzymes and aryl hydrocarbon receptor (AhR), and inhibits the overexpression of Nicotinamide N-Methyltransferase (Nnmt), leading to increased NAD(+) levels.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Majid Ghareghani, Zahra Farhadi, Serge Rivest, Kazem Zibara
Summary: Combination therapy of melatonin and DADA significantly reduced the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. The therapy improved immune response, promoted oligodendrocyte generation, and affected cerebral energy metabolism. This study highlights the importance of combined treatment for enhancing the efficiency of melatonin in remyelination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir Takase, Kotaro Iida, Mitsuru Watanabe, Katsuhisa Masaki, Marion Heleen Catherine Wijering, Hiroo Yamaguchi, Jun-ichi Kira, Noriko Isobe
Summary: This study demonstrates that iguratimod effectively alleviates clinical symptoms of progressive experimental autoimmune encephalomyelitis by suppressing Th17 migration and inhibiting IL-6 production in proinflammatory-activated glial cells.
Article
Medical Laboratory Technology
Jiannan Li, Zhan Zhang, Shuang Du, Qi Guo
Summary: Low-dose IL-2 treatment was shown to ameliorate clinical severity of EAE by reducing Th17 cells and expanding Treg cells in the spinal cord. In vitro experiments confirmed the anti-inflammatory effect of IL-2 in EAE-reactivated T cells. This suggests low-dose IL-2 as a potential therapeutic strategy for EAE and MS.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2021)
Article
Immunology
Xin Wan, Weiya Pei, Yiming Zhang, Lei Zhang, Khawar Ali Shahzad, Tao Xu, Chuanlai Shen
IMMUNOLOGICAL INVESTIGATIONS
(2018)
Article
Pharmacology & Pharmacy
Khawar Ali Shahzad, Xin Wan, Lei Zhang, Weiya Pei, Aifeng Zhang, Muhammad Younis, Wei Wang, Chuanlai Shen
Article
Nanoscience & Nanotechnology
Shilong Song, Xiaoxiao Jin, Lei Zhang, Chen Zhao, Yan Ding, Qianqian Ang, Odontuya Khaidav, Chuanlai Shen
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Oncology
Lei Zhang, Shilong Song, Xiaoxiao Jin, Xin Wan, Khawar Ali Shahzad, Weiya Pei, Chen Zhao, Chuanlai Shen
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Immunology
Xinyi Wang, Wanbo Tai, Xiaolu Zhang, Yusen Zhou, Lanying Du, Chuanlai Shen
Article
Immunology
Khawar Ali Shahzad, Muhammad Naeem, Lei Zhang, Xin Wan, Shilong Song, Weiya Pei, Chen Zhao, Xiaoxiao Jin, Chuanlai Shen
IMMUNOLOGICAL INVESTIGATIONS
(2020)
Article
Cell Biology
Yan Li, Zhongjie Qin, Lin Zhou, Khawar Ali Shahzad, Delin Xia
Summary: The treatment of cardiovascular diseases relies heavily on vascular scaffold materials to ensure normal physiological activity of endothelial cells. This study investigated the combined effects of substrate chemistries and fluid shear stress on HUVECs, showing that FSS enhances the production of key substances while the release of ATP, NO, and PGI(2) is influenced by both substrate chemistries and FSS. The study also suggests that F-actin organization and focal adhesions of HUVECs are controlled by substrate chemistries, which in turn affects the responses triggered by FSS.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Oncology
Xiaoxiao Jin, Xiaotao Liu, Zining Zhou, Yan Ding, Yandan Wu, Jie Qiu, Chuanlai Shen
Summary: In this study, 25 HLA-A0201 restricted GPC3 epitopes were predicted and 5 were identified as real-world epitopes for specific CD8(+) T cell activation. These epitopes were further confirmed to induce robust CD8(+) T cell responses and cytotoxicity targeting HepG2 cells, providing potential for the development of T cell epitope vaccines and evaluation of GPC3 specific T cell responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Juan Shi, Xiaoxiao Jin, Yan Ding, Xiaotao Liu, Anran Shen, Yandan Wu, Min Peng, Chuanlai Shen
Summary: The study constructed RBD-Fc proteins that can bind to specific mutant virus strains and demonstrated in mouse immunization experiments that these proteins can induce high levels of IgG antibodies and cross-neutralizing antibodies. Furthermore, RBD-Fc proteins with multiple amino acid substitutions showed higher antibody titers and neutralizing-antibody titers compared to those with single substitutions.
Review
Immunology
Yandan Wu, Yan Ding, Chuanlai Shen
Summary: Hepatitis B virus infection is a global health issue with no eradicative therapy available. The lack of validated T cell epitopes hampers the development of vaccines and T cell therapies, with most epitopes restricted to common HLA supertypes. More research is needed to map a comprehensive repertoire of T cell epitopes covering the HBV proteome and global populations.
Article
Biochemistry & Molecular Biology
Xueyin Mei, Xingyu Li, Chen Zhao, Anna Liu, Yan Ding, Chuanlai Shen, Jian Li
Summary: This study proposes a novel prediction strategy based on structure to assess the affinity between HBV antigenic peptides and HLA molecules. Through residue scanning, peptide docking, and molecular dynamics methods, the researchers obtained the molecular docking model of HBV peptide and HLA, and calculated the binding affinity using the MM-GBSA method. The results were consistent with experimental assays, indicating the accuracy of the affinity prediction process and the reliability of the HLA homologous modeling strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
An -Ran Shen, Xiao-Xiao Jin, Tao -Tao Tang, Yan Ding, Xiao-Tao Liu, Xin Zhong, Yan-Dan Wu, Xue-Lian Han, Guang-Yu Zhao, Chuan-Lai Shen, Lin -Li Lv, Bi-Cheng Liu
Summary: This study successfully generated an exosomal vaccine carrying T cell epitope peptides of SARS-CoV-2 and demonstrated strong CD8+ T cell response in mice. The exosomal vaccine induced significantly stronger T cell response compared to the recent cocktail vaccine.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Virology
Xiaoxiao Jin, Xiaotao Liu, Chuanlai Shen
Summary: This review provides a comprehensive map of T-cell epitopes from SARS-CoV-2 antigens, the HLA supertypes that present these epitopes, and the strategies to screen and identify T-cell epitopes. A total of 1349 CD8+ T-cell epitopes and 790 CD4+ T-cell epitopes have been defined, mostly presented by common HLA supertypes. However, the currently defined T-cell epitope repertoire does not cover the HLA polymorphism of major populations in specific geographic regions.
Article
Immunology
Juan Shi, Yu Zhao, Min Peng, Suyue Zhu, Yandan Wu, Ruixue Ji, Chuanlai Shen
Summary: The use of QS21 + MPL adjuvant improves the immunogenicity and efficacy of the RBD-Fc subunit vaccine against both the original strain and Delta strain of SARS-CoV-2. However, Imiquimod adjuvant has a negative effect on antibody production.