Article
Urology & Nephrology
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: The kidney failure risk equation (KFRE) accurately predicts kidney failure risk in people with GFR < 60 ml/min per 1.73 m(2) when using the CKD-EPI 2021 creatinine equation. Other modifications to the KFRE did not improve its performance.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Urology & Nephrology
Amy K. Mottl, Radica Alicic, Christos Argyropoulos, Frank C. Brosius, Michael Mauer, Mark Molitch, Robert G. Nelson, Leigh Perreault, Susanne B. Nicholas
Summary: KDIGO's new guideline for the care of patients with diabetes and chronic kidney disease is a significant step forward in nephrology. Recent research has provided new insights into preventing CKD progression and cardiovascular events in patients with diabetes, particularly related to SGLT2 inhibitors. These developments underscore the importance of multidisciplinary care for these patients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Kathryn E. Foti, Dan Wang, Alexander R. Chang, Elizabeth Selyin, Mark J. Sarnak, Tara Chang, Paul Muntner, Josef Coresh
Summary: The 2021 KDIGO guideline recommends a target systolic blood pressure under 120 mmHg for adults with CKD, with a focus on ACEi/ARB use for those with albuminuria; the study found that more patients in the United States meet the criteria for blood pressure lowering according to the new guideline.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Paul E. Drawz, Srinivasan Beddhu, O. N. Ray Bignall, Jordana B. Cohen, Joseph T. Flynn, Elaine Ku, Mahboob Rahman, George Thomas, Matthew R. Weir, Paul K. Whelton
Summary: The Kidney Disease Outcomes Quality Initiative (KDOQI) work group reviewed the 2021 KDIGO guideline for blood pressure management in chronic kidney disease (CKD), emphasizing the importance of accurate assessment and providing recommendations for target systolic blood pressure. However, they found weak evidence base for patients with diabetes and advanced CKD.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Johannes F. E. Mann, Tara I. Chang, William C. Cushman, Susan L. Furth, Joachim H. Ix, Fan Fan Hou, Gregory A. Knoll, Paul Muntner, Roberto Pecoits-Filho, Mark J. Sarnak, Charles R. V. Tomson, Jonathan C. Craig, David J. Tunnicliffe, Martin Howell, Marcello Tonelli, Michael Cheung, Amy Earley, Alfred K. Cheung
Summary: The updated 2021 guideline on blood pressure management in chronic kidney disease by KDIGO is based on systematic literature reviews and uses the GRADE approach. It includes chapters on BP measurement techniques, lifestyle interventions, and management in different target populations. The guideline suggests a systolic BP target of <120 mm Hg for most individuals with CKD not receiving dialysis, with exceptions for kidney transplant recipients and children, based on standardized measurements.
CURRENT CARDIOLOGY REPORTS
(2021)
Article
Endocrinology & Metabolism
Jingya Niu, Xiaoyun Zhang, Mian Li, Shujing Wu, Ruizhi Zheng, Li Chen, Yanan Huo, Min Xu, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Guijun Qin, Li Yan, Qin Wan, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Yufang Bi, Guang Ning, Weiqing Wang, Jieli Lu, Yu Xu
Summary: This study aimed to examine the risks of major cardiovascular events, renal outcomes, and all-cause mortality in type 2 diabetes mellitus patients with different diabetic kidney disease subtypes. A total of 36,509 participants with type 2 diabetes were followed up from 2011 to 2016, and the DKD subtypes were categorized based on albuminuria and reduced estimated glomerular filtration rate. The results showed that non-albuminuria DKD accounted for more than half of DKD cases with low eGFR in Chinese diabetes patients, and these patients had a modest increase in the risks of MACEs and mortality.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Simke W. Waijer, Priya Vart, David Z. Cherney, Glenn M. Chertow, Niels Jongs, Anna Maria Langkilde, Johannes F. E. Mann, Ofri Mosenzon, John J. McMurray, Peter Rossing, Ricardo Correa-Rotter, Bergur Stefansson, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: The consistent benefits of dapagliflozin on kidney and cardiovascular outcomes across different KDIGO risk categories indicate its efficacy and safety in patients with chronic kidney disease.
Article
Environmental Sciences
Maria Grau-Perez, Arce Domingo-Relloso, Tamara Garcia-Barrera, Jose L. Gomez-Ariza, Montserrat Leon-Latre, Belen Moreno-Franco, Martin Laclaustra, Eliseo Guallar, Ana Navas-Acien, Roberto Pastor-Barriuso, Josep Redon, Maria Tellez-Plaza
Summary: This study assessed the association between metal exposures and changes in renal endpoints, finding that zinc, arsenic, chromium, and tungsten may have nephrotoxic effects at low exposure levels, and other metals may also be associated with renal disease.
ENVIRONMENTAL POLLUTION
(2023)
Article
Urology & Nephrology
Benedicte Stengel, Daniel Muenz, Charlotte Tu, Elodie Speyer, Natalia Alencar de Pinho, Christian Combe, Kunihiro Yamagata, Helmut Reichel, Danilo Fliser, Ziad A. Massy, Antonio A. Lopes, Michel Jadoul, Wolfgang C. Winkelmayer, Ronald L. Pisoni, Bruce M. Robinson, Roberto Pecoits-Filho
Summary: The study found low adherence to recommendations to slow CKD progression in real-world nephrology practice, with significant variation among countries, suggesting opportunities for improvement.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Mona Khurana, Gunter F. Egger, Lynne Yao, Aliza Thompson, Chrissi Pallidis, Stuart L. Goldstein, Benjamin L. Laskin, Shamir Tuchman, Meaghan A. Malley, Katrin Uhlig
Summary: Children with CKD need safe and effective medicines, but conducting trials for pediatric drug development remains a challenge. There are difficulties in recruitment and completion, as well as a significant time lag between adult approval and pediatric labeling. This article provides an overview of regulatory frameworks, current landscape, challenges, and progress in drug development for children with CKD.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Jason H. Greenberg, Alison G. Abraham, Yunwen Xu, Jeffrey R. Schelling, Harold I. Feldman, Venkata S. Sabbisetti, Joachim H. Ix, Manasi P. Jogalekar, Steven Coca, Sushrut S. Waikar, Michael G. Shlipak, Bradley A. Warady, Ramachandran S. Vasan, Paul L. Kimmel, Joseph V. Bonventre, Michelle Denburg, Chirag R. Parikh, Susan Furth
Summary: This study showed that lower urine EGF concentration and higher urine KIM-1, MCP-1, and α-1 microglobulin concentrations were each associated with CKD progression in children, even after multivariable adjustment. The addition of these five urine biomarkers to a clinical model significantly improved discrimination and reclassification for CKD progression.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Editorial Material
Urology & Nephrology
Alexander J. Kula, Michael J. G. Somers
Summary: While the Executive Order on Advancing American Kidney Health focused on the long-underserved needs of patients with CKD, it did not include children in its scope, highlighting the continued need for special attention to the pediatric population with chronic kidney disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Melanie J. Koren, Helena M. Blumen, Emmeline I. Ayers, Joe Verghese, Matthew K. Abramowitz
Summary: In older adults with CKD, the gait phenotype is associated with cognitive dysfunction, showing poorer function in various cognitive domains. Neuroimaging reveals a pattern of gray matter atrophy linked with cognition in both CKD and the gait phenotype.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Chi D. Chu, Neil R. Powe, Deidra C. Crews, Delphine S. Tuot
Summary: This study compares the time to kidney failure with replacement therapy among Black, Hispanic, and White patients, and assesses the impact of incorporating race into the estimation of glomerular filtration rate on waitlist eligibility and time to kidney failure. The results show that Black and Hispanic patients have less opportunity to be placed on the transplant waitlist compared to White patients. For many Black patients, estimating the filtration rate as if their race were non-Black could allow for earlier waitlisting.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Hyeok-Hee Lee, Hokyou Lee, Raymond R. Townsend, Dong-Wook Kim, Sungha Park, Hyeon Chang Kim
Summary: The study found that adhering to the blood pressure target adjusted by the 2021 KDIGO guideline significantly reduces cardiovascular disease risk among non-dialysis CKD patients; for individual patients, there is a higher risk for those who only adhere to the 2012 KDIGO or 2017 ACC/AHA guidelines.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Transplantation
Emily J. See, Aminu K. Bello, Adeera Levin, Meaghan Lunney, Mohamed A. Osman, Feng Ye, Gloria E. Ashuntantang, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Sara Davison, Mohammad Ghnaimat, Paul Harden, Htay Htay, Vivekanand Jha, Kamyar Kalantar-Zadeh, Peter G. Kerr, Scott Klarenbach, Csaba P. Kovesdy, Valerie Luyckx, Brendon Neuen, Donal O'Donoghue, Shahrzad Ossareh, Jeffrey Perl, Harun Ur Rashid, Eric Rondeau, Saad Syed, Laura Sola, Irma Tchokhonelidze, Vladimir Tesar, Kriang Tungsanga, Rumeyza Turan Kazancioglu, Angela Yee-Moon Wang, Chih-Wei Yang, Alexander Zemchenkov, Ming-Hui Zhao, Kitty J. Jager, Fergus Caskey, Vlado Perkovic, Kailash K. Jindal, Ikechi G. Okpechi, Marcello Tonelli, John Feehally, David C. Harris, David W. Johnson
Summary: There are significant differences in the coverage and scope of global Health Information Systems (HIS) for kidney disease. KRT registries are available in almost all high-income countries, but rare in low-income countries. Registries for non-dialysis CKD or AKI are also rare. In high-income countries, registries tend to be national, while in low-income countries they often operate at a local or regional level.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Xu, Edouard L. Fu, Marco Trevisan, Tomas Jernberg, Arvid Sjolander, Catherine M. Clase, Juan-Jesus Carrero
Summary: Stopping renin-angiotensin system inhibitors (RASi) after an episode of hyperkalemia may reduce the risk of recurrent hyperkalemia, but is associated with higher risks of death and cardiovascular events.
AMERICAN HEART JOURNAL
(2022)
Article
Urology & Nephrology
Silvia J. Leon, Reid Whitlock, Claudio Rigatto, Paul Komenda, Clara Bohm, Ewa Sucha, Sarah E. Bota, Meltem Tuna, David Collister, Manish Sood, Navdeep Tangri
Summary: Discontinuation of RAAS inhibitors is associated with adverse clinical outcomes in patients with CKD, including high mortality, increased risk of cardiovascular events, and initiation of dialysis.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Editorial Material
Urology & Nephrology
Murray Epstein, Roberto Pecoits-Filho, Catherine M. Clase, Manish M. Sood, Csaba P. Kovesdy
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Thomas W. Ferguson, Gerard D. Harper, John E. Milad, Paul V. J. Komenda
Summary: The development of new personal hemodialysis systems has made dialysis smaller and simpler while maintaining the same effectiveness as conventional systems. Increasing the use of lower-intensity assistance and full self-care dialysis may bring economic benefits to public health payers. The study found that the annual costs of using the SC+ hemodialysis system for self-care dialysis were relatively low in the United Kingdom.
HEMODIALYSIS INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Edouard L. Fu, Catherine M. Clase, Roemer J. Janse, Bengt Lindholm, Friedo W. Dekker, Meg J. Jardine, Juan-Jesus Carrero
Summary: This study investigates the comparative effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP1-RA) on cardiovascular outcomes in routine clinical practice. The study finds no significant differences in major adverse cardiovascular events between the two therapies, but the use of SGLT2i is associated with a small increase in the risk of ischemic stroke.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Urology & Nephrology
Yang Xu, Edouard L. Fu, Catherine M. Clase, Faizan Mazhar, Meg J. Jardine, Juan J. Carrero
Summary: In this study, it was found that glucagon-like peptide-1 receptor agonists (GLP1RA) were associated with a lower risk of kidney outcomes compared to dipeptidyl peptidase-4 inhibitors (DPP4i). The reductions in both kidney outcomes and major adverse cardiovascular events (MACE) were similar in magnitude to those reported in large cardiovascular outcome trials.
KIDNEY INTERNATIONAL
(2022)
Review
Urology & Nephrology
Aminu K. Bello, Ikechi G. Okpechi, Mohamed A. Osman, Yeoungjee Cho, Htay Htay, Vivekanand Jha, Marina Wainstein, David W. Johnson
Summary: Haemodialysis is the most common form of kidney replacement therapy worldwide, but its availability, accessibility, cost, and outcomes vary across regions. Cardiovascular disease is the major cause of morbidity and mortality in haemodialysis patients. Understanding the epidemiology of haemodialysis outcomes and finding strategies for improvement are crucial.
NATURE REVIEWS NEPHROLOGY
(2022)
Editorial Material
Urology & Nephrology
Anna Mathew, Catherine M. Clase
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Ken G. Drouillard, Amanda Tomkins, Sharon Lackie, Scott Laengert, Allison Baker, Catherine M. Clase, Charles F. De Lannoy, Dora Cavallo-Medved, Lisa A. Porter, Rebecca S. Rudman
Summary: The objective of this study was to assess commercially-available cotton fabrics for the construction of cloth masks. The study found that certain cotton fabrics can produce breathable masks with filtration efficiencies comparable to medical masks.
Article
Medicine, General & Internal
Paris J. Baptiste, Angel Y. S. Wong, Anna Schultze, Marianne Cunnington, Johannes F. E. Mann, Catherine Clase, Clemence Leyrat, Laurie A. Tomlinson, Kevin Wing
Summary: Cardiovascular disease is a leading cause of death globally. Clinical trial results may not be fully applicable to underrepresented groups. This study aims to replicate previous clinical trial results using real-world data and evaluate treatment effects and risks in excluded populations.
Article
Urology & Nephrology
Oskar Swartling, Yuanhang Yang, Catherine M. Clase, Edouard L. Fu, Manfred Hecking, Sebastian Hoedlmoser, Ylva Trolle-Lagerros, Marie Evans, Juan J. Carrero
Summary: This study evaluated the sex differences in CKD patients and found that the disparities may be explained by differences in healthcare.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Editorial Material
Urology & Nephrology
Ikechi G. Okpechi, Aminu K. Bello
Article
Urology & Nephrology
Reid H. Whitlock, Mohammad Nour-Mohammadi, Sarah Curtis, Paul Komenda, Clara Bohm, David Collister, Navdeep Tangri, Claudio Rigatto
Summary: This study used administrative health databases to identify patients at high risk of Fabry disease and found that 1364 high-risk patients had not been tested. Administrative health databases can assist in identifying high-risk populations and further design screening programs for Fabry disease.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2023)
Review
Urology & Nephrology
Ali Taha, Yasmin Iman, Jay Hingwala, Nicole Askin, Priyanka Mysore, Claudio Rigatto, Clara Bohm, Paul Komenda, Navdeep Tangri, David Collister
Summary: This article conducted a systematic review on patient navigator programs in kidney disease and found that navigators can improve some health outcomes for patients with chronic kidney disease, but there is heterogeneity in their structure and function.