期刊
JOURNAL OF HOSPITAL INFECTION
卷 99, 期 2, 页码 148-152出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2017.08.016
关键词
16S rRNA PCR; Antimicrobial stewardship; Empiric antimicrobials; Neurosurgery; Cost analysis; De-escalation
Empiric broad-spectrum antimicrobial therapy frequently results in culture-negative specimens making rationalization of therapy difficult. We retrospectively reviewed 16S rRNA polymerase chain reaction (PCR) results from 78 specimens in 60 patients. 16S rRNA was detected in 28 (47%) patients with de-escalation of therapy in five (21%). Microbial DNA was not detected in 32 (53%) patients with antimicrobials discontinued in two (8%). Neurosurgical patients had a higher proportion of positive results (53% vs 34%) and treatment rationalizations (17% vs 12%). In specific patient groups, 16s rRNA PCR is a useful antimicrobial stewardship tool for targeting antimicrobial therapy. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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