Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Article
Hematology
Matt S. Zinter, Caroline A. Lindemans, Birgitta A. Versluys, Madeline Y. Mayday, Sara Sunshine, Gustavo Reyes, Marina Sirota, Anil Sapru, Michael A. Matthay, Sandhya Kharbanda, Christopher C. Dvorak, Jaap J. Boelens, Joseph L. DeRisi
Summary: This study analyzed biospecimens from 181 pediatric HCT candidates to investigate the association between pre-HCT pulmonary metatranscriptomes and post-HCT lung injury. The results showed that certain gene expression patterns and microbiome compositions in the lungs prior to transplantation were linked to an increased risk of developing lung injury after the procedure. Data from this study suggest that assessment of pre-HCT BAL fluid could potentially help identify high-risk pediatric HCT candidates who may benefit from targeted interventions.
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Review
Biochemistry & Molecular Biology
Dalila Cavallaro, Marco Guerrieri, Stefano Cattelan, Gaia Fabbri, Sara Croce, Martina Armati, David Bennett, Antonella Fossi, Luca Voltolini, Luca Luzzi, Alberto Salvicchi, Piero Paladini, Adriano Peris, Miriana d'Alessandro, Paolo Cameli, Elena Bargagli, Tuscany Transplant Group, Laura Bergantini
Summary: Bronchiolitis obliterans syndrome is the most common form of CLAD, and its pathogenesis and markers play a crucial role in early diagnosis and treatment.
Article
Respiratory System
David Ross Darley, Jin Ma, Ella Huszti, Rasheed Ghany, Michael Hutcheon, Chung-Wai Chow, Jussi Tikkanen, Shaf Keshavjee, Lianne Gail Singer, Tereza Martinu
Summary: This study aims to determine the prognostic significance of D-LCOcor on chronic lung allograft dysfunction (CLAD) and survival. The results show that low baseline D-LCOcor is significantly associated with death, and declines in D-LCOcor are associated with shorter survival. This suggests that D-LCOcor may be a useful marker for predicting poor outcomes after lung transplantation.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, General & Internal
Jesper Romhild Davidsen, Christian B. Laursen, Mikkel Hojlund, Thomas Kromann Lund, Klaus Nielsen Jeschke, Martin Iversen, Anna Kalhauge, Elisabeth Bendstrup, Jorn Carlsen, Michael Perch, Daniel Pilsgaard Henriksen, Hans Henrik Lawaetz Schultz
Summary: This study found that pleural thickening identified by lung ultrasound may serve as a potential surrogate marker to distinguish restrictive allograft syndrome (RAS) from bronchiolitis obliterans syndrome (BOS) in chronic lung allograft dysfunction (CLAD) patients after lung transplant. This discovery provides a new method for clinical diagnosis of CLAD patients post lung transplant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sudip Das, Eric Bernasconi, Angela Koutsokera, Daniel-Adrien Wurlod, Vishwachi Tripathi, German Bonilla-Rosso, John-David Aubert, Marie-France Derkenne, Louis Mercier, Celine Pattaroni, Alexis Rapin, Christophe von Garnier, Benjamin J. Marsland, Philipp Engel, Laurent P. Nicod
Summary: This study examined the viable bacterial community in bronchoalveolar lavage samples from 64 lung transplant recipients and identified four distinct compositional states, called "pneumotypes," which were associated with immune activity, lung function, and risks of infection and rejection. The findings highlight the link between the lung microbial ecosystem, human lung function, and clinical stability post-transplant.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Maria Iglesias-Escudero, David San Segundo, David Merino-Fernandez, Victor M. Mora-Cuesta, Patricia Lamadrid, Marta Alonso-Pena, Sandra Raso, David Iturbe, Sonia Fernandez-Rozas, Jose Cifrian, Marcos Lopez-Hoyos
Summary: Lung transplantation is a primary treatment for end-stage lung diseases, but long-term survival is limited. The study explores the dysregulation of immune mechanisms and the role of myeloid-derived suppressor cells (MDSCs) in promoting graft tolerance. The results suggest that increased frequencies of Mo-MDSCs after acute cellular rejection may be associated with the development of chronic lung allograft dysfunction (CLAD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Micheal C. McInnis, Jin Ma, Gauri Rani Karur, Christian Houbois, Liran Levy, Jan Havlin, Eyal Fuchs, Jussi Tikkanen, Chung-Wai Chow, Ella Huszti, Tereza Martinu
Summary: In this study, a machine learning computed tomography (CT) lung texture analysis tool was used for phenotyping and prognostication of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. The results showed that machine learning could effectively distinguish different CLAD phenotypes, and the associated parameters were able to predict the risk of graft failure.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Surgery
Naofumi Miyahara, Alberto Benazzo, Felicitas Oberndorfer, Akinori Iwasaki, Viktoria Laszlo, Balasz Dome, Mir Ali Hoda, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
Summary: miR-21 expression was higher in restrictive allograft syndrome (RAS) than in bronchiolitis obliterans syndrome (BOS) specimens, with a significant increase in serum concentration over time in RAS patients. Vimentin, NICD, and p-SMAD 2/3 were positive in a higher proportion of BOS patients compared to RAS cases.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ahad Firoz, Mohammed Kashem, Huaqing Zhao, Steven Geier, Yoshiya Toyoda
Summary: This study found that HLA mismatch is associated with the development of bronchiolitis obliterans syndrome (BOS), and a decrease in overall survival is only apparent when there are 6 mismatches. HLA-A and -DR mismatches are associated with an increased risk of mortality and BOS development. Lung transplantation offers an extended lifespan and improved quality of life for many patients with advanced refractory lung disease.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Respiratory System
Jesper M. Magnusson, Petrea Ericson, Sara Tengvall, Marit Stockfelt, Bettina Brundin, Anders Linden, Gerdt C. Riise
Summary: This pilot study revealed a significant increase in extracellular IL-26 protein concentration in BAL samples from patients with BOS, but not in samples from patients with AR. Macrophages and lymphocytes were identified as cellular sources of IL-26 protein in BAL cells obtained from BOS patients.
RESPIRATORY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Filippo Patrucco, Elias Allara, Massimo Boffini, Mauro Rinaldi, Cristina Costa, Carlo Albera, Paolo Solidoro
Summary: Chronic lung allograft dysfunction (CLAD) affects the survival of lung transplant patients and includes bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). This study evaluated the 12-month follow-up of renal and lung function in lung transplant patients treated with everolimus, showing improvements in renal function and sustained improvements in lung function for CLAD related to BOS subgroup results, while RAS confirmed a worsening trend over a year.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Immunology
Yong Wang, Cara C. Schafer, Kenneth P. Hough, Sultan Tousif, Steven R. Duncan, John F. Kearney, Selvarangan Ponnazhagan, Hui-Chen Hsu, Jessy S. Deshane
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kenneth P. Hough, Jennifer L. Trevor, John G. Strenkowski, Yong Wang, Balu K. Chacko, Sultan Tousif, Diptiman Chanda, Chad Steele, Veena B. Antony, Terje Dokland, Xiaosen Ouyang, Jianhua Zhang, Steven R. Duncan, Victor J. Thannickal, Victor M. Darley-Usmar, Jessy S. Deshane
Correction
Biochemistry & Molecular Biology
Sunad Rangarajan, Nathaniel B. Bone, Anna A. Zmijewska, Shaoning Jiang, Dae Won Park, Karen Bernard, Morgan L. Locy, Saranya Ravi, Jessy Deshane, Roslyn B. Mannon, Edward Abraham, Victor Darley-Usmar, Victor J. Thannickal, Jaroslaw W. Zmijewski
Article
Multidisciplinary Sciences
Kenneth P. Hough, Landon S. Wilson, Jennifer L. Trevor, John G. Strenkowski, Njeri Maina, Young-Il Kim, Marion L. Spell, Yong Wang, Diptiman Chanda, Jose Rodriguez Dager, Nirmal S. Sharma, Miranda Curtiss, Veena B. Antony, Mark T. Dransfield, David D. Chaplin, Chad Steele, Stephen Barnes, Steven R. Duncan, Jeevan K. Prasain, Victor J. Thannickal, Jessy S. Deshane
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Diptiman Chanda, Eva Otoupalova, Kenneth P. Hough, Morgan L. Locy, Karen Bernard, Jessy S. Deshane, Ralph D. Sanderson, James A. Mobley, Victor J. Thannicka
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Review
Allergy
K. P. Hough, J. S. Deshane
CURRENT ALLERGY AND ASTHMA REPORTS
(2019)
Editorial Material
Critical Care Medicine
Sunad Rangarajan, Victor J. Thannickal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Review
Biochemical Research Methods
Kenneth P. Hough, Jessy S. Deshane
Article
Cell Biology
Alexandra Pritchard, Sultan Tousif, Yong Wang, Kenneth Hough, Saad Khan, John Strenkowski, Balu K. Chacko, Victor M. Darley-Usmar, Jessy S. Deshane
Article
Medicine, Research & Experimental
Yong Wang, Kayla F. Goliwas, Paige E. Severino, Kenneth P. Hough, Derek Van Vessem, Hong Wang, Sultan Tousif, Roy P. Koomullil, Andra R. Frost, Selvarangan Ponnazhagan, Joel L. Berry, Jessy S. Deshane
LABORATORY INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Morgan L. Locy, Sunad Rangarajan, Sufen Yang, Mark R. Johnson, Karen Bernard, Ashish Kurundkar, Nathaniel B. Bone, Jaroslaw W. Zmijewski, Jaeman Byun, Subramaniam Pennathur, Yong Zhou, Victor J. Thannickal
Review
Medicine, General & Internal
Kenneth P. Hough, Miranda L. Curtiss, Trevor J. Blain, Rui-Ming Liu, Jennifer Trevor, Jessy S. Deshane, Victor J. Thannickal
FRONTIERS IN MEDICINE
(2020)
Article
Cell Biology
Sunad Rangarajan, Morgan L. Locy, Diptiman Chanda, Ashish Kurundkar, Deepali Kurundkar, Jennifer L. Larson-Casey, Pilar Londono, Rushita A. Bagchi, Brian Deskin, Hanan Elajaili, Eva S. Nozik, Jessy S. Deshane, Jaroslaw W. Zmijewski, Oliver Eickelberg, Victor J. Thannickal
Summary: This study provides evidence that elevated levels of the mitochondrial protein UCP2 are associated with age-related diseases, such as idiopathic pulmonary fibrosis. UCP2 is shown to contribute to the generation of reactive oxygen species and altered cellular bioenergetics, as well as induce myofibroblast senescence. The findings suggest that targeting UCP2 could be a potential therapeutic strategy for age-related diseases associated with impaired tissue regeneration and organ fibrosis.
Editorial Material
Biochemistry & Molecular Biology
Sunad Rangarajan
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)