Effect of a calcitonin gene-related peptide-binding L-RNA aptamer on neuronal activity in the rat spinal trigeminal nucleus

Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib–dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study

(2017) H Ludwig et al.   LEUKEMIA

The role of anti-CGRP antibodies in the pathophysiology of primary headaches

(2017) Piero Barbanti et al.   NEUROLOGICAL SCIENCES

Vessel diameter measurements at the medullary brainstem in vivo as an index of trigeminal activity

(2016) Christine Will et al.   BRAIN RESEARCH

A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine

(2016) Tiffini Voss et al.   CEPHALALGIA

Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial

(2016) Hong Sun et al.   LANCET NEUROLOGY

C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria

(2016) Jan Menne et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation

(2015) K Hoehlig et al.   BRITISH JOURNAL OF PHARMACOLOGY

Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine

(2015) Tony W Ho et al.   CEPHALALGIA

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

(2015) Axel Vater et al.   DRUG DISCOVERY TODAY

Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study

(2015) Marcelo E Bigal et al.   LANCET NEUROLOGY

Hydrogen sulfide determines HNO-induced stimulation of trigeminal afferents

(2015) Vanessa Wild et al.   NEUROSCIENCE LETTERS

Release of CGRP from mouse brainstem slices indicates central inhibitory effect of triptans and kynurenate

(2014) Charlotte Kageneck et al.   JOURNAL OF HEADACHE AND PAIN

Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study

(2014) David W Dodick et al.   LANCET NEUROLOGY

Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial

(2014) David W Dodick et al.   LANCET NEUROLOGY

Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention

(2014) T. W. Ho et al.   NEUROLOGY

Calcitonin gene–related peptide regulates the early phase of liver regeneration

(2012) Tetsushi Mizutani et al.   JOURNAL OF SURGICAL RESEARCH

Possible site of action of CGRP antagonists in migraine

(2011) Peer Tfelt-Hansen et al.   CEPHALALGIA

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

(2010) Jakob Møller Hansen et al.   CEPHALALGIA

Calcitonin gene-related peptide receptor antagonists for migraine

(2010) Michael JM Fischer   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus

(2009) Marie-Luise Sixt et al.   BRAIN

The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice

(2009) Irena Kroeger et al.   JOURNAL OF HEPATOLOGY

Randomized, controlled trial of telcagepant for the acute treatment of migraine

(2009) K. M. Connor et al.   NEUROLOGY

Target site occupancy: Emerging generalizations from clinical and preclinical studies

(2009) Sarah Grimwood et al.   PHARMACOLOGY & THERAPEUTICS

CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat

(2008) J Zeller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcitonin Gene-Related Peptide Receptor Inhibition Reduces Neuronal Activity Induced by Prolonged Increase in Nitric Oxide in the Rat Spinal Trigeminal Nucleus

(2008) S Kulchitsky et al.   CEPHALALGIA

Serum Concentrations of s100b and NSE in Migraine

(2008) Michael Teepker et al.   HEADACHE

Inhibitory effect of BIBN4096BS, CGRP8-37, a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery

(2007) L Edvinsson et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide

(2006) Thomas Denekas et al.   BRITISH JOURNAL OF PHARMACOLOGY