All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner

Activation gating in HCN2 channels

(2018) Sabine Hummert et al.   PLoS Computational Biology

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance

(2017) Sebastien Hayoz et al.   PLoS One

Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening

(2016) Leo C.T. Ng et al.   STRUCTURE

Structure and dynamics underlying elementary ligand binding events in human pacemaking channels

(2016) Marcel P Goldschen-Ohm et al.   eLife

Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides

(2015) Susanne Thon et al.   BIOPHYSICAL JOURNAL

Elementary Functional Properties of Single HCN2 Channels

(2013) S. Thon et al.   BIOPHYSICAL JOURNAL

Unraveling Subunit Cooperativity in Homotetrameric HCN2 Channels

(2012) Klaus Benndorf et al.   BIOPHYSICAL JOURNAL

Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate

(2012) Sujung Ryu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural changes during HCN channel gating defined by high affinity metal bridges

(2012) Daniel C.H. Kwan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Probability Fluxes and Transition Paths in a Markovian Model Describing Complex Subunit Cooperativity in HCN2 Channels

(2012) Klaus Benndorf et al.   PLoS Computational Biology

Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

(2011) Marco Lolicato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energetics of Cyclic AMP Binding to HCN Channel C Terminus Reveal Negative Cooperativity

(2011) Sarah S. Chow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels

(2011) Jana Kusch et al.   Nature Chemical Biology

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

(2010) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interdependence of Receptor Activation and Ligand Binding in HCN2 Pacemaker Channels

(2010) Jana Kusch et al.   NEURON

Alanine Scanning of the S6 Segment Reveals a Unique and cAMP-sensitive Association between the Pore and Voltage-dependent Opening in HCN Channels

(2009) Vincenzo Macri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS