Article
Plant Sciences
Janith V. S. Aluthmuhandiram, K. W. T. Chethana, Wei Zhang, Junbo Peng, Ercheng Zhao, Xing Hong Li, N. Saichana, Jiye Yan
Summary: This study evaluated the impact of temperature on phytotoxin-induced virulence in Lasiodiplodia theobromae, revealing that the production of plant toxins increased at higher temperatures, resulting in significantly higher toxicity to grapevine leaves.
JOURNAL OF PHYTOPATHOLOGY
(2021)
Article
Plant Sciences
Dongmei Zhang, Kaijie Zhu, Xingyi Shen, Jian Meng, Xue Huang, Yuqi Tan, Francesca Cardinale, Jihong Liu, Guohuai Li, Junwei Liu
Summary: Two ethylene response factors (ERFs), PpERF98 and PpERF1, have been identified as negative regulators in peach response to L. theobromae infection. Silencing of PpERF98-1/2 increases peach resistance to L. theobromae through increasing SA content and pathogenesis-related gene expression. PpERF98-1/2 directly bind the promoters of PpERF1 genes and activate the ERF branch of the jasmonate/ethylene signaling pathway.
Article
Plant Sciences
Nick Gould, Michael R. Thorpe, Joe T. Taylor, Helen L. Boldingh, Catherine M. McKenzie, Tony Reglinski
Summary: The research demonstrates that after treatment with jasmonates, there is a shift in carbon allocation in grapevines, with more fixed carbon being allocated to the roots and no change in the relative sink strength of the berries. Additionally, an increase in sugar concentration in the berries is observed after treatment, which could be explained by the initial storage of fixed carbon in the roots followed by remobilisation to the berries.
Review
Chemistry, Multidisciplinary
Michaela Mergova, Andrea Balazova, Marek Oblozinsky, Ivana Holkova, Pavel Mucaji, Silvia Bittner Fialova
Summary: Jasmonates, derived from jasmonic acid, are lipid-derived oxylipins that are formed through dioxygenation mediated by lipoxygenases. The biosynthesis of jasmonic acid involves a series of enzymes, including lipoxygenase, allene oxide synthase, allene oxide cyclase, and 12-oxophytodienoic acid reductase, as well as three rounds of beta-oxidation. The resulting metabolites, known as jasmonates, can interact with the jasmonate receptor and initiate the jasmonate signaling pathway. The gene products resulting from this pathway play a significant role in plant growth, development, reproduction, senescence, and defense against adverse environmental conditions.
Review
Plant Sciences
Jinjing Pan, Houping Wang, Qiugui You, Rui Cao, Guiling Sun, Diqiu Yu
Summary: JA-mediated seed germination involves crosstalk with other phytohormones, especially ABA and GA, and light interacts with JA in germination mainly via effects on the GA and ABA signaling pathways. Seed plants have evolved mechanisms that maintain the dormancy of mature seeds until the time is appropriate for germination. Seed germination is a critical step in the plant life cycle, and it is an important trait in relation to agricultural production.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Nadia Gul, Khalid Z. Masoodi, Salika Ramazan, Javid Mir, Saima Aslam
Summary: The study found that MeJA can reduce LT stress in Solanum lycopersicum plants. The J2 concentration of MeJA can significantly alleviate the adverse consequences of LT stress. Therefore, supplying the optimal concentration of MeJA exogenously to LT stressed Solanum lycopersicum can be a smart strategy to mitigate the harmful impact of LT stress.
Article
Plant Sciences
Pham Anh Tuan, Talia Shafai, Gurkamal Kaur, Ginelle Grenier, Belay T. Ayele
Summary: Jasmonates play important roles in plant growth and response to stresses. This study identified a highly conserved gene, TaJAR1B, in wheat that is involved in plant growth, development, and response to salt stress.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Article
Microbiology
Ruiying Li, Pu Zheng, Xingyun Sun, Wenhua Dong, Ziqiang Shen, Pengcheng Chen, Dan Wu
Summary: In this study, the genome of a high jasmonate-producing strain, Lasiodiplodia iranensis DWH-2, was sequenced and analyzed. The genome was found to be 43.01 Mb in size with a GC content of 54.82%. Core genes involved in the pathogenicity of Lasiodiplodia genus, carbohydrate-active enzymes genes, and known biosynthetic gene clusters were identified. These findings provide important genomic data for understanding the application value of L. iranensis DWH-2.
Article
Plant Sciences
Bipin K. Pandey, Lokesh Verma, Ankita Prusty, Ajit Pal Singh, Malcolm J. Bennett, Akhilesh K. Tyagi, Jitender Giri, Poonam Mehra
Summary: OsJAZ11 regulates phosphate homeostasis by suppressing jasmonic acid signaling and biosynthesis in rice roots, promoting root elongation and enhancing phosphate uptake. This study highlights the functional connections between JA and phosphate signaling, demonstrating JAZ repressors as a promising candidate for improving low phosphate tolerance in elite rice genotypes.
Review
Biochemistry & Molecular Biology
Iwona Jarocka-Karpowicz, Agnieszka Markowska
Summary: Jasmonates, such as jasmonic acid and methyl jasmonate, are natural compounds with broad spectrum of activities, including anti-cancer, anti-inflammatory, and cosmetic effects. Studies on their biological activity in mammals have shown potential for inflammation treatment due to their structural similarities to prostaglandins. Furthermore, jasmonates are being considered as potential anti-cancer drugs when used alone or in combination with other chemotherapy agents, and may also have applications in cosmetics and dermatology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Joon Yung Cha, Shahab Uddin, Donah Mary Macoy, Gyeong-Im Shin, Song Yi Jeong, Imdad Ali, Ji-Won Hwang, Myung Geun Ji, Sang Cheol Lee, Joung Hun Park, Marium Sultana, Gyeong Ryul Ryu, Gyeongik Ahn, Sang Yeol Lee, Min Gab Kim, Woe-Yeon Kim
Summary: Tomato production faces challenges from various biotic stresses, such as fungi, bacteria, and viruses. Researchers used the CRISPR/Cas9 system to modify tomato genes, resulting in increased resistance against bacterial and fungal pathogens. This study contributes to improving crop breeding for enhanced biotic stress resistance.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yang Han, Dawn Luthe
Summary: JAZ genes and key genes in the JA signaling pathway play important roles in defending against fall armyworm in maize, but their expression varies in different genotypes, and insect-derived factors are crucial for optimal defense responses.
JOURNAL OF CHEMICAL ECOLOGY
(2022)
Review
Plant Sciences
Soo-In Sohn, Subramani Pandian, Kasinathan Rakkammal, Muthiah Joe Virgin Largia, Senthil Kumar Thamilarasan, Sekaran Balaji, Yedomon Ange Bovys Zoclanclounon, Jayabalan Shilpha, Manikandan Ramesh
Summary: Secondary metabolites are important specialized molecules with proven health-promoting effects on humans. Exogenous jasmonates (JAs) have been recognized for their ability to trigger plant growth and development and can also effectively elicit the synthesis of secondary metabolites. However, large-scale production of these metabolites is limited, but advancements in plant cell culture technology and synthetic biology offer potential avenues for overcoming this limitation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemical Research Methods
Ziqiang Shen, Pu Zheng, Ruiying Li, Xingyun Sun, Pengcheng Chen, Dan Wu
Summary: By selecting solid substrate and optimizing culture conditions, a maximum JA yield of 5306.38 mg kg(-1) was achieved in a SSF process with Lasiodiplodia iranensis. Models were used to characterize microbial growth and product synthesis, predicting a maximum JA production close to experimental value. LC-MS/MS was used to examine metabolic changes during fermentation, revealing key intermediate metabolites and byproducts of JA biosynthesis.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Immunology
Yawei Que, Donghai Huang, Shuangjun Gong, Xuejiang Zhang, Bin Yuan, Minfeng Xue, Wenqi Shi, Fansong Zeng, Meilin Liu, Tingting Chen, Dazhao Yu, Xia Yan, Zhengyi Wang, Lijun Yang, Libo Xiang
Summary: This study isolated three compounds from an endophytic fungus and evaluated their antifungal activity against wheat powdery mildew. Results showed that jasmonic acid exhibited higher bioactivity and there was a significant synergistic effect between jasmonic acid and indole-3-carboxylic acid.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Srichandan Padhi, Marco Masi, Yugal Kishore Mohanta, Muthupandian Saravanan, Swati Sharma, Alessio Cimmino, Dhivya Shanmugarajan, Antonio Evidente, Kumananda Tayung, Amit Kumar Rai
Summary: Seventy-three anticancer metabolites from different endolichenic fungi previously reported were analyzed for drug likeliness and pharmacokinetic properties. Three compounds, including talaromycin A, pyridoxatin, and terricollene A, showed strong binding affinity and stability, potentially serving as glycolytic inhibitors. These findings contribute to the development of potential glycolytic inhibitors for treating and controlling various forms of cancer, but further experimental investigations are needed to evaluate the efficacy of these compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Plant Sciences
Antonio Moreno-Robles, Antonio Cala Peralta, Jesus G. Zorrilla, Gabriele Soriano, Marco Masi, Susana Vilarino-Rodriguez, Alessio Cimmino, Monica Fernandez-Aparicio
Summary: This study investigates the inhibitory effects of trans-cinnamic acid and its derivatives on the growth of Cuscuta campestris, a parasitic weed causing significant yield losses in crops. The findings reveal that some derivatives of trans-cinnamic acid exhibit enhanced growth inhibition activity against C. campestris seedlings, with the methyl ester derivative being the most active compound. This structure-activity relationship study provides valuable information for the design of herbicidal treatments targeting parasitic weeds.
Article
Biochemistry & Molecular Biology
Shurooq Ismail, Rosa Gaglione, Marco Masi, Srichandan Padhi, Amit K. Rai, Ghadeer Omar, Alessio Cimmino, Angela Arciello
Summary: This study purified extracts from Ephedra foeminea and identified bioactive compounds with antimicrobial and antibiofilm properties. The compound kaempferol-3-O-alpha-L-(2 '',4 ''-di-E-p-coumaroyl)-rhamnopyranoside exhibited strong antibacterial and antibiofilm activity against S. aureus strains. Molecular docking studies suggested its potential applicability in biomedical and biotechnological fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pierluigi Reveglia, Carmela Paolillo, Antonella Angiolillo, Gabriella Ferretti, Ruggero Angelico, Rossana Sirabella, Gaetano Corso, Carmela Matrone, Alfonso Di Costanzo
Summary: Alzheimer's disease is the most common cause of dementia in the elderly population. It not only affects the brain, but also disturbs the overall metabolism of the body. Analysis of blood samples from patients with AD revealed significant dysregulation of metabolites, including upregulation of glycerophospholipids and ceramide, and downregulation of glutamic acid, other phospholipids, and sphingolipids. Pathway analysis showed that at least five metabolic pathways related to polar compounds were dysregulated in AD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Francisco J. Agudo-Jurado, Pierluigi Reveglia, Diego Rubiales, Antonio Evidente, Eleonora Barilli
Summary: Fungal phytotoxins, as secondary metabolites toxic to host plants, play a role in the development of symptoms in legume diseases by targeting host cellular machineries or interfering with host immune responses. This review focuses on the isolation, chemical and biological characterization of fungal phytotoxins produced by necrotrophic fungi involved in legume diseases. The possible role in plant-pathogen interaction and structure-toxicity relationship studies are also discussed. Additionally, multidisciplinary studies on other biological activities of reviewed phytotoxins are described, along with the challenges in identifying new fungal metabolites and their potential applications in future experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Antonio Evidente
Summary: The alkaloids derived from Amaryllidaceae plants have been used in folk medicine since ancient times and are classified into different subfamilies and carbon skeletons. Over the past two decades, more than 600 alkaloids with various biological activities have been isolated from regions including Southern Africa, Andean South America, and the Mediterranean basin.
Correction
Biochemistry & Molecular Biology
Marco Masi, Angela Boari, Francisco Sautua, Marcelo Anibal Carmona, Maurizio Vurro, Antonio Evidente
Review
Microbiology
Antonio Evidente
Summary: Weeds, including parasite plants, have become a serious problem for farmers, causing significant losses in agricultural and herding production and hindering reforestation practices and important infrastructure. To combat these pests, synthetic herbicides have been widely used, leading to environmental pollution and risks to human and animal health. This review explores the potential of fungal phytotoxins as bioherbicides, as well as the commercial availability and future perspectives of bioherbicides based on microbial toxic metabolites.
Article
Plant Sciences
Jennifer Millera Niem, Regina Billones-Baaijens, Benjamin J. Stodart, Pierluigi Reveglia, Sandra Savocchia
Summary: This study aimed to develop an effective biocontrol strategy against the grapevine trunk disease pathogen Neofusicoccum luteum. The results showed that a strain of Pseudomonas poae (BCA17) could effectively suppress N. luteum infection and colonize grapevine tissues, producing bioactive antibacterial compounds that reduced spore germination and fungal biomass. The study suggested that P. poae BCA17 may have a novel mode of action for biocontrol.
Article
Microbiology
Jesus G. Zorrilla, Marco Masi, Suzette Clement, Alessio Cimmino, Susan Meyer
Summary: (10S,11S)-(-)-epi-pyriculol is a phytotoxic metabolite produced by Pyricularia grisea, a fungus that infects the invasive weed species buffelgrass. This study developed a high-pressure liquid chromatography (HPLC) method for quantifying (10S,11S)-(-)-epi-pyriculol in complex mixtures. The results showed that the production of (10S,11S)-(-)-epi-pyriculol varied among different P. grisea isolates and was strongly correlated with phytotoxic activity. The HPLC method could be used for selecting the best strain and cultural conditions for mass production of (10S,11S)-(-)-epi-pyriculol, thus providing a new bioherbicide for the control of buffelgrass.
Article
Microbiology
Stefany Castaldi, Jesus G. Zorrilla, Claudia Petrillo, Maria Teresa Russo, Patrizia Ambrosino, Marco Masi, Alessio Cimmino, Rachele Isticato
Summary: Alternaria alternata is a devastating phytopathogenic fungus that causes black spots in many fruits and vegetables. In this study, the pathogenicity mechanisms and competitive exclusion of A. alternata were investigated, with a focus on its interaction with Botrytis cinerea. The fungus was found to produce strong enzymatic activities and four different toxins, which showed varying levels of necrotic activity on different hosts. Interestingly, A. alternata exhibited competitive exclusion of B. cinerea in host and non-host pear fruits, inhibiting its growth by 70% and 65%, respectively. The toxins Alteichin and alternariol 4-methyl ether showed the strongest inhibition activity against B. cinerea.