期刊
JOURNAL OF EXPERIMENTAL BIOLOGY
卷 221, 期 11, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jeb.159533
关键词
Ecology; zebrafish; Drosophila; Cavefish; Genetic screen; Natural variation
类别
资金
- National Institutes of Health [R21 NS105071, R01 NS08152]
- National Science Foundation [1656575]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM127872] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS105071, R01NS085152] Funding Source: NIH RePORTER
Sleep is nearly ubiquitous throughout the animal kingdom, yet little is known about how ecological factors or perturbations to the environment shape the duration and timing of sleep. In diverse animal taxa, poor sleep negatively impacts development, cognitive abilities and longevity. In addition to mammals, sleep has been characterized in genetic model organisms, ranging from the nematode worm to zebrafish, and, more recently, in emergent models with simplified nervous systems such as Aplysia and jellyfish. In addition, evolutionary models ranging from fruit flies to cavefish have leveraged natural genetic variation to investigate the relationship between ecology and sleep. Here, we describe the contributions of classical and emergent genetic model systems to investigate mechanisms underlying sleep regulation. These studies highlight fundamental interactions between sleep and sensory processing, as well as a remarkable plasticity of sleep in response to environmental changes. Understanding how sleep varies throughout the animal kingdom will provide critical insight into fundamental functions and conserved genetic mechanisms underlying sleep regulation. Furthermore, identification of naturally occurring genetic variation regulating sleep may provide novel drug targets and approaches to treat sleep-related diseases.
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