Article
Chemistry, Multidisciplinary
Dianwen Han, Lijuan Wang, Li Long, Peng Su, Dan Luo, Hanwen Zhang, Zheng Li, Bing Chen, Wenjing Zhao, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Guohong Hu, Qifeng Yang
Summary: The loss of TRIM4 in tamoxifen-resistant breast cancer cells is associated with an unfavorable prognosis. TRIM4 increases the sensitivity of breast cancer cells to TAM by increasing ER-α expression. TRIM4 targets SET and promotes ESR1 gene transcription and mRNA stability by facilitating the proteasomal degradation and disassociation of SET from p53 and PP2A. TRIM4 expression is an independent predictor of overall survival and recurrence-free survival outcomes in breast cancer patients.
Article
Cell Biology
Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou, Qingsong Huang, Huijie Yang
Summary: In this study, the researchers found that TRIM3, an E3 ligase, promotes ER alpha signaling activity and breast cancer progression. Depletion of TRIM3 inhibits breast cancer cell proliferation and migration, and unbiased RNA sequencing data showed that TRIM3 is crucial for estrogen signaling activity on a genome-wide scale. The researchers also demonstrated that TRIM3 associates with ER alpha and promotes its stability by inducing a specific ubiquitin modification. These findings provide a novel posttranslational mechanism in estrogen signaling and suggest that modulation of TRIM3 expression or function could be a promising approach for breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Huijie Yang, Xulei Lv, Xin Li, Lanzhi Mao, Zhiguo Niu, Ting Wang, Ting Zhuang, Qingsong Huang
Summary: The study investigated the role of Zinc finger protein 213 in ER alpha protein stability and tamoxifen resistance, revealing its correlation with poor outcomes in endocrine treated patients. Depletion of ZNF213 inhibited ER alpha signaling and proliferation in breast cancer cells, suggesting it as a potential target for ER alpha positive breast cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Angeles C. Tecalco-Cruz, Marina Macias-Silva, Josue Orlando Ramirez-Jarquin, Uri Nimrod Ramirez-Jarquin
Summary: This minireview highlights the molecular mechanisms involved in regulating ER alpha stability and nucleocytoplasmic transport, providing information for novel biomarkers, therapeutic targets, and promising strategies in breast cancer treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Jianing Ding, Peng Kuang
Summary: ERα plays a crucial role in breast tumor development, and HOIL-1 is involved in modulating ERα signaling, showing good prognosis in ERα positive breast cancer but poor outcome in patients receiving endocrine therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Guosheng Luo, Quanhui Li, Miao Yu, Tianshi Wang, Yifeng Zang, Ziping Liu, Zhiguo Niu, Huijie Yang, Jianghua Lai
Summary: The study identifies UHRF1 as an important regulator for breast cancer growth and shows its correlation with survival in breast cancer patients.
Article
Oncology
Ying Zhao, Jing Ruan, Zhongding Li, Xian Su, Kangmin Chen, Yimin Lin, Yuepiao Cai, Peng Wang, Baohua Liu, Dirk Schlueter, Guang Liang, Xu Wang
Summary: This study reveals that CCN6 protein levels in breast cancer are regulated by ubiquitination and deubiquitinating enzymes (DUBs). OTUB1 is identified as a novel DUB for CCN6 and inhibits its degradation by interacting with CCN6 and inhibiting its K48 ubiquitination. Deletion of OTUB1 results in decreased CCN6 abundance and increased migration, proliferation, and viability of breast cancer cells, which can be rescued by supplementation of CCN6. Importantly, OTUB1 expression is downregulated in human breast cancer and positively correlated with CCN6 levels.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Lei Yuan, Xin Li, Huijie Yang, Huixiang Li
Summary: This study identifies RNF2 as an important posttranslational modification regulator of estrogen receptor (ER) alpha, and suggests that targeting RNF2 could be a promising strategy for breast cancer treatments. The depletion of RNF2 inhibits breast cancer cell progression and ER alpha signaling activity. TCGA data analysis reveals a positive correlation between RNF2 and both breast malignancies and ER alpha target gene expression.
Article
Oncology
Christoforos Thomas, Ilias Karagounis, Ratnesh K. Srivastava, Nicholas Vrettos, Fotis Nikolos, Noelle Francois, Menggui Huang, Siliang Gong, Qi Long, Sushil Kumar, Constantinos Koumenis, Savitri Krishnamurthy, Naoto T. Ueno, Rumela Chakrabarti, Amit Maity
Summary: Studies have shown that in inflammatory breast cancer, ERβ can act as a tumor suppressor by inhibiting cell migration and reducing metastasis.
Article
Oncology
Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Daniel G. Stover, Mathew A. Cherian
Summary: Highly selective ER beta agonists have been shown to effectively inhibit the viability of ER alpha+ breast cancer cell lines in vitro, suggesting a potential therapeutic strategy for ER alpha+ breast cancer. The combination of ER beta agonists with ER alpha antagonists shows strong synergy, maximizing the efficacy of ER beta agonists in blocking cell proliferation, migration, and inducing apoptosis. Negative correlation between ESR2 (ER beta gene) expression and ESR1 (ER alpha gene) and CCND1 RNA expression was observed in human metastatic ER alpha+/HER2- breast cancer samples.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Weixiao Huang, Xiong Liu, Yao Zhang, Mingxia Deng, Guangqiang Li, Guo Chen, Li Yu, Lai Jin, Tongzheng Liu, Yijie Wang, Yan Chen
Summary: USP5 is a novel deubiquitinase for HIF2 alpha in breast cancer, interacting with HIF2 alpha to protect it from degradation. USP5 promotes the transcription of HIF2 alpha target genes and its high expression is correlated with poor clinical outcomes in breast cancer patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Jinhui Lue, Qian Zhao, Yuefan Guo, Danni Li, Heying Xie, Cuicui Liu, Xin Hu, Suling Liu, Zhaoyuan Hou, Xunbin Wei, Deyou Zheng, Richard G. Pestell, Zuoren Yu
Summary: This study identified a miR-29a-PTEN-AKT axis as a downstream signaling pathway of ER alpha in breast cancer metastasis. Low level of miR-29a was associated with reduced metastasis and better survival in ER alpha+ luminal subtype of BC, while high level of miR-29a was detected in ER alpha- triple negative breast cancer (TNBC) with distant metastasis and poor survival. Targeting miR-29a suppressed cellular invasion, EMT and lung metastasis in TNBC cells in vitro and in TNBC tumor-bearing mice in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Hai -Li Tang, Qi Wang, Jian-Guo Lu, Xiao-Jun Yang, Jiao-Jiao Shi, Sheng-Peng Wang, Chang-Qing Cao, Hua-Dong Zhao
Summary: This study found that the high expression of GDF11 in breast cancer tissues and cells was associated with poor patient survival. Silencing GDF11 inhibited the proliferation, migration, and invasion of breast cancer cells, while promoting cell apoptosis. Furthermore, GDF11 was shown to regulate the SMURF1-mediated p53 and ER alpha pathways, contributing to breast cancer progression.
Article
Biochemistry & Molecular Biology
Kyung-Taek Kang, Min-Joo Shin, Hye-Ji Moon, Kyung-Un Choi, Dong-Soo Suh, Jae-Ho Kim
Summary: This study found that TRRAP overexpression increases NANOG protein stability and enhances the tumorigenic potential of colon cancer stem cells. TRRAP inhibits the ubiquitination degradation of NANOG by binding to it. TRRAP knockdown decreases the expression of CD44, a cancer stem cell marker, and increases the expression of P53, a tumor suppressor gene, in colon cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Pengfei Yang, Xiu Feng, Jin Li, Tianyi Zhang, Chengyan Sheng, Liying Zhang, Junrui Hua, Wenjun Wei, Nan Ding, Jinpeng He, Yanan Zhang, Jufang Wang, Heng Zhou
Summary: Breast cancer is a significant threat to women's health, with estrogen receptor-positive (ER+) breast cancer having the highest incidence among these cancers. This study aimed to investigate the mechanisms underlying radiation-induced inhibition of ER+ breast cancer cells proliferation. The findings show that ionizing radiation reduces estrogen receptor phosphorylation and estradiol secretion by ER+ breast cancer cells, induces endoplasmic reticulum stress, downregulates CYP19A expression, and ultimately inhibits cellular proliferation.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Qianqian Zheng, Liangwei Duan, Yang Zhang, Jiaoyang Li, Shiyu Zhang, Hui Wang
Summary: Autophagy is a cellular degradation process that maintains cellular homeostasis and protects organisms from environmental stress. Pathogens have evolved strategies to interfere with autophagy and utilize autophagic degradation for their own proliferation and reproduction.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Oncology
Yunwei Lou, Miaomiao Song, Meijuan Han, Jiateng Zhong, Xueqin Tian, Yahan Ren, Yaru Song, Liangwei Duan, Peiqing Zhao, Xiangfeng Song, Wen Zhang, Youhai H. Chen, Hui Wang
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou, Qingsong Huang, Huijie Yang
Summary: In this study, the researchers found that TRIM3, an E3 ligase, promotes ER alpha signaling activity and breast cancer progression. Depletion of TRIM3 inhibits breast cancer cell proliferation and migration, and unbiased RNA sequencing data showed that TRIM3 is crucial for estrogen signaling activity on a genome-wide scale. The researchers also demonstrated that TRIM3 associates with ER alpha and promotes its stability by inducing a specific ubiquitin modification. These findings provide a novel posttranslational mechanism in estrogen signaling and suggest that modulation of TRIM3 expression or function could be a promising approach for breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Virology
Huandi Liu, Jiaxiang Sun, Xuhong Cheng, Liangwei Duan, Shuaifeng Guo, Zhongxin Zhang, Jia Wan, Chunduo Wang, Xiaoying Zhi, Linghui Yuan, Hui Wang
Summary: The study discovered that hydrogen sulfide (H2S) can play an antiviral role by regulating autophagy, leading to decreased expression of human T-cell leukemia virus type-1 (HTLV-1) protein. This finding provides a new mechanism for defending against virus infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Genshen Zhong, Qi Wang, Ying Wang, Ying Guo, Meiqi Xu, Yaya Guan, Xiaoying Zhang, Minna Wu, Zhishan Xu, Weidong Zhao, Hongkai Lian, Hui Wang, Jianping Ye
Summary: ATPIF1 plays a role in inducing CD8(+) T cell function in tumor models. Inactivation of the ATPIF1 gene impairs immune activity of CD8(+) T cells and promotes tumor growth, while overexpression of ATPIF1 enhances T cell tumor immunity.
Article
Cell Biology
Jie Wang, Xiao Qin, Yulu Huang, Qunmei Zhang, Jinyong Pei, Yi Wang, Idan Goren, Shujun Ma, Zhishan Song, Yanzi Liu, Hongxia Xing, Hui Wang, Bo Yang
Summary: In this study, the researchers identified a new signaling pathway that regulates intracellular bacterial infection and autophagy. They found that the ubiquitination of ATG7 at the K413 site promotes its function. This research may enhance our understanding of host defense against bacteria and the role of autophagy in bacterial infection.
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Food Science & Technology
Wen-Juan Zhang, Ke-Yun Li, Yi Lan, Han-Yi Zeng, Shui-Qin Chen, Hui Wang
Summary: Inflammation is a crucial factor in the development of organ diseases, and the NLRP3 inflammasome is the most well-studied inflammasome. The NLRP3 inflammasome is composed of NLRP3, ASC, and pro-caspase-1. It can be activated through classical, non-canonical, and alternative pathways, and its activation is involved in various inflammatory diseases. Factors such as genetics, environment, chemicals, and viral infections can activate the NLRP3 inflammasome and promote inflammation in organs. However, the mechanisms and effects of NLRP3 inflammation in different cells and tissues are still not fully understood.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Microbiology
Jinhui Wang, Kui Guo, Shuaijie Li, Diqiu Liu, Xiaoyu Chu, Yaoxin Wang, Wei Guo, Cheng Du, Xiaojun Wang, Zhe Hu
Summary: Salmonella enterica subsp. enterica serovar Abortusequi is a major pathogen in horse and donkey herds, causing abortion in pregnant equids and resulting in enormous economic losses. A TaqMan-based real-time PCR assay targeting the gene for the flagellin protein phase 2 antigen FljB was developed. This assay exhibited high specificity, sensitivity, and reproducibility, and could detect S. Abortusequi DNA in culture-negative clinical samples.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Virology
Jie Wang, Xiao Qin, Yulu Huang, Ge Zhang, Yue Liu, Yuhan Cui, Yi Wang, Jinyong Pei, Shujun Ma, Zhishan Song, Xiaofei Zhu, Hui Wang, Bo Yang
Summary: In this study, it was found that Sirt1 interacts with IFI16 and regulates IFI16-mediated innate host defense. Sirt1 decreases the acetylation of IFI16, inhibiting its cytoplasmic localization and antiviral response against DNA viruses. Interestingly, Sirt1 has minimal interaction with the murine ortholog of IFI16, p204. Rating: 7/10
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Zheng, Liangwei Duan, Zhihua Jiang, Tingxuan Gu, Bojie Zhang, Jiaoyang Li, Yang Zhang, Shiyu Zhang, Yinming Liang, Hui Wang
Article
Immunology
Hui Liu, Lin Zeng, Mengmeng Pan, Liwenhui Huang, Hanying Li, Mengxia Liu, Xinqing Niu, Chenguang Zhang, Hui Wang
Summary: The study explores the role of Bcl-3 in T cell metabolism and function through the mTOR pathway. Depletion of Bcl-3 inhibits proliferation but promotes activation of Jurkat T cells, and regulates cellular energy metabolism by affecting intracellular ATP, ROS production levels, and mitochondrial membrane potential. Bcl-3 also influences the expression of mTOR-related genes in Jurkat cells.
Article
Biochemistry & Molecular Biology
Genshen Zhong, Ying Guo, Xue Gong, Meiqi Xu, Qi Wang, Minna Wu, Xiaoying Zhang, Yinming Liang, Weidong Zhao, Hui Wang, Jianping Ye
Summary: The inactivation of ATPIF1 enhances the bactericidal activity of neutrophils, possibly through increasing the levels of ROS and LA. RNA-seq analysis also reveals the downregulation of several genes involved in glutathione metabolism, pyruvate oxidation, and heme synthesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Hui Liu, Lin Zeng, Yang Yang, Zhen Huang, Chunlei Guo, Liwenhui Huang, Xinqing Niu, Chenguang Zhang, Hui Wang
Summary: Bcl-3 is an atypical I kappa B family member that regulates transcription in the nucleus. It has a metabolic regulatory effect on autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Bcl-3 deficiency leads to an increase in lactate levels in Th17 cells, affecting their pathogenicity through energy metabolism regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Guosheng Luo, Quanhui Li, Miao Yu, Tianshi Wang, Yifeng Zang, Ziping Liu, Zhiguo Niu, Huijie Yang, Jianghua Lai
Summary: The study identifies UHRF1 as an important regulator for breast cancer growth and shows its correlation with survival in breast cancer patients.