Article
Plant Sciences
Elizabeth Syowai Mutinda, Elijah Mbandi Mkala, Consolata Nanjala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Festus Kimutai, Jing Tian, Moses Kirega Gichua, Robert Wahiti Gituru, Guang-Wan Hu
Summary: The review paper provides a comprehensive overview of the ethnobotanical uses, phytochemistry, and pharmacology of Fagaropsis species. The study highlights the need for further research opportunities to explore the medicinal value of this genus and their potential in treating various diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Jing Zhou, Renfeng An, Xuefeng Huang
Summary: The genus Lilium has diverse traditional uses and chemical components, exhibiting a variety of pharmacological activities for treating different diseases, especially showing potential in anti-inflammatory and antioxidant effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Niranjan Das, Andreia C. F. Salgueiro, Debasish Roy Choudhury, Sudip Kumar Mandal, Rajan Logesh, Md. Mahadi Hassan, Hari Prasad Devkota
Summary: Vitex genus, consisting of about 230 species mainly found in warm regions of Europe and temperate regions of Asia, has been traditionally used as folk medicine for treating various diseases. With over 556 chemical constituents identified in different Vitex species, there is a wide range of pharmacological activities exhibited by crude extracts and pure phytochemicals. Further research is needed to explore the pharmacological potential and mechanisms of action of compounds from this genus for potential drug discovery.
PHYTOTHERAPY RESEARCH
(2022)
Review
Plant Sciences
Dan Ren, Zhan-yun Shen, Lu-ping Qin, Bo Zhu
Summary: Scrophularia ningpoensis, known as Xuanshen, has been used in traditional Chinese medicine to treat various diseases. More than 162 compounds have been identified in the plant, showing pharmacological properties that affect multiple body systems and protect against inflammation, oxidation, and carcinogenesis. Further research is needed to fully understand its medicinal properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Wenbo Zhu, Zhibin Wang, Yanping Sun, Bingyou Yang, Qiuhong Wang, Haixue Kuang
Summary: Genus Syringa, a traditional Chinese herbal medicine plant, has been found to possess various bioactivities such as anti-inflammatory, antioxidant, and anticancer effects. However, there is a lack of research on the pharmacokinetics and toxicity of Syringa extracts and compounds, limiting the development of new drugs based on Syringa species. Further studies on pharmacokinetics and toxicology are essential for evaluating the effectiveness and safety of drugs derived from Syringa.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Ajay Sharma, Raymond Cooper, Garima Bhardwaj, Damanjit Singh Cannoo
Summary: Nepeta species are widely used in traditional medicine in various regions including the Himalayan region, Pakistan, Nepal, China, Turkey, and Iran. They contain a rich source of bioactive compounds with pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. Further comprehensive clinical trials are needed to explore the potential of different Nepeta species for treating a wide range of ailments and other potential uses in the future.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Elijah Mbandi Mkala, Jing Ren, Festus Kimutai, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Consolata Nanjala, Moses Kirega Gichua, Moses Muguci Njire, Guang-Wan Hu
Summary: Veronicastrum is a multifunctional plant widely used in traditional medicine for various disorders. Phytochemical investigations have identified 89 chemical constituents, including flavonoids, carbohydrates, iridoids, terpenoids, phytosterols, and phenolic acids. The extracts and compounds from this genus exhibit a wide range of pharmacological activities such as immunosuppressive, antioxidant, anti-cancer, anti-inflammatory, gastroprotective, and antimicrobial effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Plant Sciences
Jie Shen, Mengyin Hu, Wei Tan, Jiwei Ding, Baoping Jiang, Lei Xu, Hasimu Hamulati, Chunnian He, Yuhua Sun, Peigen Xiao
Summary: The review highlights the traditional uses, phytochemistry, pharmacological activities, and potential toxicity of Coreopsis tinctoria, confirming its efficacy in treating infections and chronic metabolic diseases. This plant is considered a valuable medicinal resource for a wide range of diseases, with flavonoids identified as the major bioactive components responsible for its diverse biological and pharmacological activities. Further high-quality studies are needed to explore the efficacy and mechanisms of action of C. tinctoria in future research.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Surekha Kumari, Anmol, Vinod Bhatt, Patil Shivprasad Suresh, Upendra Sharma
Summary: Cissampelos pareira, a traditional medicinal plant, has been extensively used in Chinese medicine to treat diseases such as ulcers, rheumatism, and inflammation. Research has shown that it contains various bioactive compounds with pharmacological activities such as anti-inflammatory and anti-ulcer effects. However, further studies are needed to fully understand its toxicological profile.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Li Yang, Junwei He
Summary: Hosta species are valuable plants rich in steroids and flavonoids, known for their anti-inflammatory, analgesic, and antioxidant properties. However, gaps in understanding traditional uses exist, requiring further high-quality research to assess safety and efficacy.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Emmanuel Nyongesa Waswa, Felix Wambua Muema, Wyclif Ochieng Odago, Elizabeth Syowai Mutinda, Consolata Nanjala, Elijah Mbandi Mkala, Sarah Getachew Amenu, Shi-Xiong Ding, Jing Li, Guang-Wan Hu
Summary: Blechnum species have been traditionally used in folk medicines to treat various ailments. They contain a wide range of chemical compounds, including phenolic compounds, sterols, and fatty acids. These plants exhibit exceptional biological properties such as antioxidant, antimicrobial, anti-inflammatory, anticancer, insecticidal, antitrematocidal, and wound healing activities. However, understanding their scientific significance based on available data remains challenging.
Review
Plant Sciences
Yogita Dahat, Priyanka Saha, J. T. Mathew, Sushil K. Chaudhary, Amit K. Srivastava, Deepak Kumar
Summary: Pterocarpus santalinus, an ancient folk medicine from south India, has been traditionally used to alleviate inflammatory disorders. With a rich phytochemical profile, this plant shows promising pharmaceutical potential, urging further research in pharmacological exploration.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Wen-jin Zhang, Zhen-yu Zhao, Li-kun Chang, Ye Cao, Sheng Wang, Chuan-zhi Kang, Hong-yang Wang, Li Zhou, Lu-qi Huang, Lan-ping Guo
Summary: Atractylodis Rhizoma, including Atractylodes lancea and Atractylodes chinensis, is widely used in East Asia for its diuretic and stomachic properties, as well as its treatment of rheumatic diseases, digestive disorders, night blindness, and influenza. Research has shown that it contains a variety of medicinal components and exhibits various pharmacological activities, particularly in improving gastrointestinal function.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Xu Zhu, Lin Wang, Tie Zhao, Qinghua Jiang
Summary: Salvia miltiorrhiza, also known as danshen, is an important medicinal herb with various pharmacological activities, including anti-inflammatory, antioxidant, and anticoagulant effects. It is widely used in traditional Chinese medicine for the treatment of hypertension, cardiovascular diseases, and stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Xiuhua Meng, Jiawei Li, Mimi Li, Hongjiang Wang, Bingru Ren, Jian Chen, Weilin Li
Summary: Gynura cass., a plant belonging to the family Compositae, has been widely used in traditional medicine in tropical Asia countries such as China, Thailand, Indonesia, Malaysia, and Vietnam for various ailments. This review provides a comprehensive summary of the geographical distribution, traditional uses, chemical constituents, pharmacological activities, safety, and toxicity of Gynura species, aiming to support rational development and utilization of these medicinal plant resources in the future. Further research is needed to elucidate the mechanisms of toxicity induced by pyrrolizidine alkaloids and develop effective detoxification strategies for the safe and reasonable utilization of Gynura plant resources.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)