Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents

(2018) Ayesha Zafar et al.   MOLECULES

New benzothiophene derivatives as dual COX-1/2 and 5-LOX inhibitors: synthesis, biological evaluation and docking study

(2017) Mostafa MM El-Miligy et al.   Future Medicinal Chemistry

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents

(2017) Ayesha Zafar et al.   MOLECULES

Synthesis of 3-Amino-2-carboxamide Tetrahydropyrrolo[2,3-b]quinolines

(2016) David Barker et al.   SYNLETT

Experimental research Mechanism of endothelial cyto-protective and thrombo-resistance effects of sildenafil, vardenafil and tadalafil in male rabbit

(2015) Mohamed-I Kotb El-Sayed et al.   Archives of Medical Science

Synergistic effects of anethole and ibuprofen in acute inflammatory response

(2015) Edirlene S. Wisniewski-Rebecca et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The structure of ibuprofen bound to cyclooxygenase-2

(2015) Benjamin J. Orlando et al.   JOURNAL OF STRUCTURAL BIOLOGY

Synthesis and Characterization of Some Novel Substituted Thiazolo[3,2-a]pyridine and Thioxopyrimido[4,5-d]pyrimidine Derivatives

(2014) Nagy M. Khalifa et al.   ASIAN JOURNAL OF CHEMISTRY

Cardiovascular Risk with Non-steroidal Anti-inflammatory Drugs: Clinical Implications

(2014) Alfonso E. Bello et al.   DRUG SAFETY

Licofelone: A dual COX/5-LOX inhibitor attenuates intracerebroventricular streptozotocin-induced cognitive deficit, oxidative stress and neuro-inflammatory cytokines in rats

(2013) Rahul Deshmukh et al.   Alzheimers & Dementia

Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflammatory agents

(2013) Huan Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663

(2012) Nathaniel C. Gilbert et al.   FASEB JOURNAL

Design, Synthesis and in Vivo Anti-inflammatory Activities of 2,4-Diaryl-5-4H-imidazolone Derivatives

(2012) Moustafa El-Araby et al.   MOLECULES

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

(2011) William L. Smith et al.   CHEMICAL REVIEWS

The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2

(2011) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

Novel thienopyridine derivatives as specific anti-hepatocellular carcinoma (HCC) agents: Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation

(2010) Xiu-Xiu Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The 1.85 Å Structure of an 8R-Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

(2009) David B. Neau et al.   BIOCHEMISTRY

Synthesis, reactions and biological activity of 2-substituted 3-cyano-4,6-dimethylpyridine derivatives

(2009) F. A. Yassin   Chemistry of Heterocyclic Compounds

Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach

(2009) Ritesh N. Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structure-based molecular design, synthesis, and in vivo anti-inflammatory activity of pyridazinone derivatives as nonclassic COX-2 inhibitors

(2009) Khaled A. M. Abouzid et al.   MEDICINAL CHEMISTRY RESEARCH

Modeling of cyclooxygenase-2 and 5-lipooxygenase inhibitory activity of apoptosis-inducing agents potentially useful in prostate cancer chemotherapy: Derivatives of diarylpyrazole

(2008) B. K. Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology

(2008) Hedi Harizi et al.   TRENDS IN MOLECULAR MEDICINE