Article
Endocrinology & Metabolism
Rachel M. B. Bell, Elisa Villalobos, Mark Nixon, Allende Miguelez-Crespo, Lee Murphy, Angie Fawkes, Audrey Coutts, Matthew G. F. Sharp, Martha Koerner, Emma Allan, Onno C. Meijer, Rene Houtman, Alex Odermatt, Katharina R. Beck, Scott G. Denham, Patricia Lee, Natalie Z. M. Homer, Brian R. Walker, Ruth A. Morgan
Summary: Carbonyl reductase 1 regulates glucocorticoid and mineralocorticoid receptor activation in adipose tissue, influencing glucose homeostasis in lean mice.
MOLECULAR METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Bin Zhang, Mengshi Yang, Qiongyu Yan, Xiaojian Xu, Fei Niu, Jinqian Dong, Yuan Zhuang, Shenghua Lu, Qianqian Ge, Baiyun Liu
Summary: The study found that different doses of corticosterone have dual effects on hippocampal cell survival and spatial memory in rats, with low doses improving cell survival and memory, while high doses may have the opposite effect. This suggests that endogenous glucocorticoids have neuroprotective and neurotoxic effects depending on the threshold level, and caution should be exercised with higher doses after traumatic brain injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Seungjae Zhang, Myunghyun Cheon, Hoyong Park, Taejoon Kim, ChiHye Chung
Summary: FKBP5 is a protein that inhibits the translocation of the glucocorticoid receptor, and its expression is related to psychiatric disorders. Deletion of FKBP5 in the brain makes rodents resilient to stress-induced depression. Our study found that FKBP5 deletion in the hippocampus causes changes in synaptic transmission and insensitivity to activated glucocorticoid receptors.
Article
Neurosciences
Thaddeus M. Barney, Andrew S. Vore, Sarah L. Trapp, Cristal L. Finkenberg, Dominique R. Pugliesi, Megha M. Schmalzle, Shani H. Evans, Elena Varlinskaya, Terrence Deak
Summary: Binge drinking causes rapid changes in neuroimmune gene expression and activates the hypothalamic-pituitary-adrenal axis. Inhibiting the synthesis of corticosterone can prevent the gene expression changes caused by ethanol. Ethanol can suppress the expression of IL-1 beta and TNF alpha in the hippocampus through the release of corticosterone. These findings provide potential interventions to reduce alcohol intake and alleviate ethanol-induced neuroimmune activation.
Article
Endocrinology & Metabolism
Lisa L. Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sanchez-Lopez, Jari F. Scheerstra, Maaike C. Voorhoeve, Ajith N. Nadamuni Ramesh, Patrick C. N. Rensen, Martin Giera, Jan Kroon, Onno C. Meijer
Summary: Add-on treatment with corticosterone can partially attenuate the metabolic effects of synthetic glucocorticoid dexamethasone, while exacerbating other effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Cedric Zimmer, Conor C. Taff, Daniel R. Ardia, Kimberly A. Rosvall, Christine Kallenberg, Alexandra B. Bentz, Audrey R. Taylor, L. Scott Johnson, Maren N. Vitousek
Summary: This study compares gene expression in female tree swallows from different breeding environments and finds that the expression of glucocorticoid and mineralocorticoid receptors in the hypothalamus varies among populations. The variation in circulating glucocorticoids predicts differences in gene expression, suggesting a combination of local adaptation and phenotypic plasticity in the stress response. The results highlight the importance of considering regulatory traits in the evolutionary study of stress response.
HORMONES AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Paula Aldaz, Amaya Fernandez-Celis, Natalia Lopez-Andres, Imanol Arozarena
Summary: Dexamethasone (DEXA) is commonly used in glioblastoma (GBM) patients to reduce brain inflammation, activating the glucocorticoid receptor (GR) which can influence the mineralocorticoid receptor (MR) signaling. MR signaling in GBM has been shown to have anti-proliferative effects and inhibit the self-renewal of GSCs, while spironolactone (SPI) may not have significant anti-neoplastic potential in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alberto Dinarello, Annachiara Tesoriere, Paolo Martini, Camilla Maria Fontana, Davide Volpato, Lorenzo Badenetti, Francesca Terrin, Nicola Facchinello, Chiara Romualdi, Oliana Carnevali, Luisa Dalla Valle, Francesco Argenton
Summary: In this study, zebrafish mutant lines and transgenic models were used to analyze the mechanism of action of glucocorticoids. The differences in gene expression patterns between different mutant lines revealed a complex network of GC-dependent transcription. The study also showed that the glucocorticoid receptor GR plays a crucial role in the transcriptional activity of Stat3, and both glucocorticoids and the mineralocorticoid receptor MR are necessary for the correct transcription of certain target genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Robert H. Oakley, Natallia Riddick, Sheryl S. Moy, John A. Cidlowski
Summary: Many stress-related neuropsychiatric disorders show significant sex differences in terms of frequency and symptoms. Glucocorticoids, the primary stress hormones, have been implicated in the development of these disorders, but their contribution to the observed sex bias is poorly understood. This study investigates the effects of glucocorticoids on gene expression and behavior in the hippocampus, revealing sex-dependent and independent actions of glucocorticoids. The findings have important implications for the treatment of stress-related neuropsychiatric disorders in both men and women.
NEUROBIOLOGY OF STRESS
(2024)
Article
Biochemistry & Molecular Biology
Dorien Clarisse, Stefan Prekovic, Philip Vlummens, Eleni Staessens, Karlien Van Wesemael, Jonathan Thommis, Daria Fijalkowska, Guillaume Acke, Wilbert Zwart, Ilse M. Beck, Fritz Offner, Karolien De Bosscher
Summary: The interaction between glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) improves drug efficacy in multiple myeloma. Co-treatment of the GR agonist dexamethasone (Dex) with the MR antagonist spironolactone (Spi) enhances cell killing in myeloma, and this combination treatment affects the expression of prognosis-related genes and proteins in myeloma patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Robert H. Oakley, Shannon D. Whirledge, Maria G. Petrillo, Natallia Riddick, Xiaojiang Xu, Sheryl S. Moy, John A. Cidlowski
Summary: The study revealed that mice lacking MR or both GR and MR in the hippocampus exhibited altered expression of neuronal markers and enhanced cue-dependent learning in behavior experiments. Furthermore, mice depleted of both GR and MR showed profound neurodegeneration of the hippocampus, with increased cell death and reduced neurogenesis. Global gene expression assays indicated a synergistic increase in dysregulated genes in the hippocampus lacking both GR and MR, associated with cell death and proliferation pathways.
NEUROBIOLOGY OF STRESS
(2021)
Article
Biochemistry & Molecular Biology
Xuan Zhang, Yinghui Wei, Xiaoxuan Li, Chengyu Li, Liangliang Zhang, Zhaojun Liu, Yan Cao, Weijian Li, Xiying Zhang, Jiaqing Zhang, Ming Shen, Honglin Liu
Summary: CORT inhibits Lhcgr expression in mouse ovarian granulosa cells (GCs), leading to impaired follicular development. The effect of CORT is mediated by its receptor Nr3c1 in GCs. Nr3c1 may regulate Lhcgr transcription by inhibiting the expression of Lhcgr transcription factors AP1 and Creb.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Shihui Guo, Zijin Chen, Yingying Dong, Yingdong Ni, Ruqian Zhao, Wenqiang Ma
Summary: Copper is essential for human health, but chronic stress can lead to disorders in copper metabolism. In this study, it was found that corticosterone impairs copper transport by down-regulating intestinal CTR1 expression via GR-mediated transcriptional inhibition. This study provides a theoretical basis for regulating copper homeostasis under chronic stress.
Article
Cell Biology
Anna Gromotowicz-Poplawska, Piotr Szoka, Agnieszka Zakrzeska, Patrycjusz Kolodziejczyk, Natalia Marcinczyk, Janusz Szemraj, Piotr Tutka, Ewa Chabielska
Summary: The study found that aldosterone can enhance arterial thrombosis in rats, especially under diabetic and hyperglycemic conditions. Aldosterone shortens bleeding time, increases levels of tissue factor and plasminogen activator inhibitor in plasma, decreases levels of nitric oxide metabolites, and increases oxidative stress. Aldosterone induces a prothrombotic phenotype in endothelial cells, particularly under hyperglycemic conditions, by impacting primary hemostasis, the TF-dependent coagulation cascade, fibrinolysis, NO bioavailability, and oxidative stress balance.
Article
Cell Biology
Sascha Tafelski, Jan D. D. Wandrey, Mohammed Shaqura, Xueqi Hong, Antje Beyer, Michael Schaefer, Shaaban A. A. Mousa
Summary: The activation of MR and GR receptors on peripheral sensory neurons can modify pain perception through direct and indirect pathways. The expression of MR and GR was examined in sensory neuron subpopulations in human and rat peripheral nerves. MR showed colocalization with CGRP, TRPV1, and Nav1.8 in both human and rat nerve tissue, while GR primarily colocalized with NF200 positive mechanoreceptive fibers. Intrathecal administration of GR agonist decreased mechanical hyperalgesia, while MR agonist increased it in rats. These findings suggest a translational approach to sensory modulation through MR and GR activation.
Article
Clinical Neurology
Jonas M. den Heijer, Willem M. Otte, Eric van Diessen, Jolien S. van Campen, E. Lorraine Hompe, Floor E. Jansen, Marian Joels, Kees P. J. Braun, Josemir W. Sander, Maeike Zijlmans
Review
Physiology
M. Joels, H. Karst, R. A. Sarabdjitsingh
Article
Behavioral Sciences
Silviu I. Rusu, Jan V. Lankelma, Jadin C. Jackson, Laura A. Van Mourik-Donga, Marian Joels, Cyriel M. A. Pennartz
BEHAVIOURAL PHARMACOLOGY
(2018)
Article
Anatomy & Morphology
Michel R. T. Sinke, Willem M. Otte, Daan Christiaens, Oliver Schmitt, Alexander Leemans, Annette van der Toorn, R. Angela Sarabdjitsingh, Marian Joels, Rick M. Dijkhuizen
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Endocrinology & Metabolism
Remmelt R. Schur, Judith M. C. van Leeuwen, Lotte C. Houtepen, Marian Joels, Rene S. Kahn, Marco P. Boks, Christiaan H. Vinkers
PSYCHONEUROENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Jolien S. van Campen, Ellen V. S. Hessel, Kirsten Bohmbach, Giorgio Rizzi, Paul J. Lucassen, Sada Lakshmi Turimella, Eduardo H. L. Umeoka, Gideon F. Meerhoff, Kees P. J. Braun, Pierre N. E. de Graan, Marian Joels
FRONTIERS IN ENDOCRINOLOGY
(2018)
Review
Behavioral Sciences
V. Bonapersona, M. Joels, R. A. Sarabdjitsingh
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2018)
Article
Behavioral Sciences
Jiska Kentrop, Claire R. Smid, E. J. M. Achterberg, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, Marian Joels, Rixt van der Veen
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Behavioral Sciences
Jelle Knop, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, Marian Joels, Rixt van der Veen
GENES BRAIN AND BEHAVIOR
(2020)
Article
Psychology, Developmental
Jiska Kentrop, Aikaterini Kalamari, Chiara Hinna Danesi, John J. Kentrop, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg, Marian Joels, Rixt van der Veen
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2020)
Article
Neurosciences
Milou S. C. Sep, Marian Joels, Elbert Geuze
Summary: This study investigates the individual characteristics that affect memory contextualization after stress. The results show that factors such as life adversity, trait anxiety, salivary cortisol level, and alpha-amylase reactivity are related to memory contextualization during different stages of the stress response.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Rehabilitation
Riemer J. K. Vegter, Helco G. van Keeken, Sonja de Groot, Han J. P. Houdijk, Marian Joels, Lucas H. V. van der Woude
DISABILITY AND REHABILITATION
(2021)
Review
Multidisciplinary Sciences
Heike Schuler, Valeria Bonapersona, Marian Joels, R. Angela Sarabdjitsingh
Summary: Early-life adversity causes long-lasting changes to the brain that increase vulnerability to psychopathologies later in life. Immediate-early genes (IEGs) can serve as markers for these alterations, connecting activity-regulated transcription to long-term effects on brain structure and function. A systematic review of 39 pre-clinical studies in rodents found that ELA (alteration of maternal care) affected IEG expression, particularly in relation to cFos expression after acute stressors and at rest. These findings suggest that ELA creates a phenotype similar to naive, acutely stressed animals.
Article
Neurosciences
Henk Karst, Wouter J. Droogers, Nelleke van der Weerd, Ruth Damsteegt, Nicky van Kronenburg, R. Angela Sarabdjitsingh, Marian Joels
Summary: Early life stress (ELS) alters the excitation-inhibition-balance (EI-balance) in the mouse brain by influencing the GABA-switch, which is accelerated in ELS mice compared to controls. This accelerated switch is associated with increased expression of the inward chloride transporter NKCC1. Both pre- and postsynaptic chloride homeostasis are affected by this switch, leading to altered glutamatergic transmission.
Review
Behavioral Sciences
Marian Joels
Summary: Mary Dallman has left a significant legacy in neuroendocrinology, both as a scientist who contributed new concepts and as a role model for women in the field. This article compares her journey as the first female faculty member at UCSF with subsequent generations, discusses the contribution of our labs on rapid corticosteroid actions, and highlights the importance of keeping an open mind in scientific research, a principle advocated by Mary Dallman.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)