Article
Acoustics
Rafey A. Feroze, Jonathan Kopechek, Jianhui Zhu, Xucai Chen, Flordeliza S. Villanueva
Summary: This study investigated the potential of using ultrasound-targeted microbubble cavitation (UTMC) to deliver miR-29b and mitigate cardiac fibrosis while preserving left ventricular (LV) function. The results showed that UTMC treatment with miR-29b-loaded microbubbles reduced fibrosis markers and preserved cardiac function in cell and mouse models.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kuo-Wei Chen, Po-Hung Hsu, Hau-Lun Huang, Hao-Li Liu, Ya-Tin Lin, Che-Yu Hsu, Jui-Hsiang Lin, Yu-Hsin Lin
Summary: This study utilizes targeted nanoparticle-conjugated microbubbles to ensure effective penetration of tumor barriers, access to the tumor microenvironment, and local drug release, utilizing ultrasound to release the nanoparticles. It is demonstrated that targeted nanoparticles can enter gastric cancer cells through ligand-specific recognition, leading to enhanced cell growth inhibition through drug delivery-induced apoptosis. Additionally, the ultrasound combined with nanoparticle-based drug delivery system significantly enhances anti-tumor activity in targeted gastric cancer.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rongbiao Tang, Yongfang Li, Le Qin, Fuhua Yan, Guo-Yuan Yang, Ke-Min Chen
Summary: This study evaluated the feasibility of using PR-based PCCT with microbubble contrast agent for vascular imaging. Results showed that microbubbles provided weaker contrast enhancement compared to iodine, but still sufficient for imaging rat aortas. The imaging modality can currently be used as a complement or alternative to absorption-based microCT for imaging vessels in biological samples.
Article
Nanoscience & Nanotechnology
Li Wei, Qianhui Liang, Wei Zhou, Haiyang Han, Zuyi Mao
Summary: This study focused on exploring the application value of microbubble contrast agents in the diagnosis of prostate cancer. By preparing targeted nano-microbubbles, the study demonstrated a strong targeting performance and enhancement effect in vitro and in vivo experiments. Compared with routine trans-rectal ultrasound (TRUS) diagnosis, the targeted nano-bubbles showed marked advantages in terms of sensitivity, specificity, and accuracy in diagnosing prostate cancer.
SCIENCE OF ADVANCED MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Zhaojian Wang, Huaigu Huang, Yuexin Chen, Yuehong Zheng
Summary: This article summarizes the potential application of microbubbles with enhanced ultrasound in treating thrombotic diseases, focusing on novel strategies for targeted delivery to thrombus and discussing current challenges.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Jing Yang, Xiaoyan Miao, Yu Guan, Chaojin Chen, Sufang Chen, Xinmin Zhang, Xue Xiao, Zheng Zhang, Zhengyuan Xia, Tinghui Yin, Ziqing Hei, Weifeng Yao
Summary: Utilizing platelet membrane-coated microbubbles for molecular ultrasound imaging has potential to improve early detection of sepsis-induced acute kidney injury, showing promising results in a rat model. This approach may enhance selective adhesion to damaged endothelium and offer a diagnostic advantage over traditional methods.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Yanan Feng, Yongsheng Hao, Yuanyuan Wang, Weijian Song, Shanxin Zhang, Dong Ni, Fei Yan, Litao Sun
Summary: In this study, a nanoscale acoustic probe based on gas vesicles (GVs) was developed by conjugating ZD2 peptides to the biosynthetic GVs. The resulting ZD2-GVs showed excellent binding capability to tumor cells and demonstrated strong penetration ability in tumor tissues. This study suggests that ZD2-GVs can serve as a potential UMI probe for early diagnosis of bladder cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Hengli Yang, Ping Zhao, Yonggang Zhou, Qiaoying Li, Wenbin Cai, Zongxia Zhao, Jian Shen, Kechun Yao, Yunyou Duan
Summary: IR780-NBs-DTX, a novel nanosized ultrasound contrast agents (UCAs), show excellent performance in dual-mode molecular targeted imaging and combined therapy for pancreatic cancer, with high efficiency and potential applications in precise detection and effective therapy of small and metastatic lesions.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner, Massimo Mischi, Simona Turco
Summary: Investigation of a unique second-wave phenomenon in nanobubble contrast-enhanced ultrasound (CEUS) imaging was conducted. The second wave was observed accompanying the first pass of the contrast agent bolus, which has not been previously observed in CEUS with microbubbles. The study aimed to investigate this phenomenon and its potential clinical applications, and found that the characteristics of the second wave differed between tumor and normal tissue, suggesting its potential for cancer diagnosis.
SCIENTIFIC REPORTS
(2022)
Review
Biotechnology & Applied Microbiology
Natacha Jugniot, Rakesh Bam, Emmanuelle J. Meuillet, Evan C. Unger, Ramasamy Paulmurugan
Summary: PDAC is often diagnosed late with limited treatment options, highlighting the urgent need for new imaging technologies with high sensitivity and specificity. CETUS, a novel molecular imaging modality, shows promise for accurate detection of PDAC and has potential clinical translational applications.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Chao Zhang, Shuyuan Chen, Qunying Li, Jiao Wu, Fuqiang Qiu, Zhiyi Chen, Yang Sun, Jieli Luo, Raul A. Bastarrachea, Paul A. Grayburn, Ralph A. DeFronzo, Yajing Liu, Kun Qian, Pintong Huang
Summary: The study demonstrated successful gene delivery of GLP-1 in macaques using UTMD, leading to enhanced GLP-1 expression and improvement in pancreatic beta cell regeneration and plasma glucose regulation. This approach shows promising alternatives for treating type 2 diabetes.
Article
Engineering, Biomedical
Lauren J. Delaney, John R. Eisenbrey, David Brown, Jonathan R. Brody, Masaya Jimbo, Brian E. Oeffinger, Maria Stanczak, Flemming Forsberg, Ji-Bin Liu, Margaret A. Wheatley
Summary: Ultrasound imaging has many advantages, and the development of microbubble contrast agents presents new opportunities for drug delivery. Gemcitabine-loaded microbubbles show potential therapeutic effects for pancreatic cancer.
ACTA BIOMATERIALIA
(2021)
Article
Oncology
Chanjuan Peng, Yong Wu, Yang Yang, Ningning Li, Xi Chen, Linhui Gu, Dong Xu, Chen Yang
Summary: The study demonstrated the enhanced destructive effect of UTMD combined with 4 Gy radiotherapy on glioblastoma, likely achieved through increased ability of DNA damage of tumor cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Acoustics
Mawia Khairalseed, Kenneth Hoyt
Summary: A generalized mathematical framework called pulse inversion spectral deconvolution (PISD) for contrast-enhanced ultrasound (CEUS) imaging is introduced in this article. The PISD approach is based on Gaussian derivative functions (GDFs) and uses PISD pulses to filter backscattered ultrasound (US) data for isolating nonlinear (NL) microbubble (MB) signals. The study evaluates the role of wide-beam transmit aperture size in CEUS imaging and quantifies image enhancement using a contrast-to-noise ratio (CNR). In vivo data collected in rats demonstrates that PISD-based CEUS imaging improves vascular visualization compared to the NL imaging strategy.
Article
Chemistry, Multidisciplinary
Jinhui Gao, Keiran A. Logan, Heather Nesbitt, Bridgeen Callan, Thomas McKaig, Mark Taylor, Mark Love, Anthony P. McHale, Darren M. Griffith, John F. Callan
Summary: FIRINOX MB, an ultrasound responsive microbubble formulation containing 5-fluorouridine, irinotecan, and oxaliplatin, enhances the delivery of FIRINOX chemotherapy, resulting in significantly improved tumor growth delay and survival prospects in preclinical murine models of pancreatic and colorectal cancer. This improved efficacy is achieved at substantially lower drug loadings compared to standard FOLFIRINOX treatment, suggesting potential for reduced systemic levels and adverse effects.
JOURNAL OF CONTROLLED RELEASE
(2021)