Early predictors of diabetic retinopathy in type 1 diabetes: The Retinopathy Champagne Ardenne Diabete (ReCAD) study

Aims: To determine the relationship between early markers of diabetes control and diabetic retinopathy (DR) in type 1 diabetes. Methods: A historic cohort study was conducted on 712 patients from the CAReDIAB database. HbA(1c) and usual metabolic parameters were measured one year after diagnosis of diabetes. First occurrences of severe hypoglycemia and ketoacidosis during follow-up were selected as time-dependent markers of diabetes control. Data were analyzed in a Cox model using SPSS software to predict DR with significance level at p-value <0.05. Results: In multivariate regression, any diabetic retinopathy was predicted by HbA(1c) (HR = 138; CI = 1.25-1.52; p < 0.0001), severe hypoglycemia (HR = 3; CI = 1.99-4.52; p < 0.0001), ketoacidosis (HR = 1.96; CI = 1.17-3.22; p = 0.009), and age at diagnosis (HR = 1.016; CI = 1.002-1.031; p = 0.02). Proliferative DR was predicted by HbA(1c) (HR = 1.67; CI = 1.51-1.79; p < 0.0001), severe hypoglycemia (HR = 3.67; CI = 2.74-5.25; p < 0.0001), and ketoacidosis (HR = 2.37; CI = 1.56-3.18; p < 0.0001). Conclusion: This study shows that the failure to achieve diabetes control after the first year of diagnosis as well as early episodes of acute diabetes complications may contribute to the occurrence of diabetic retinopathy in type 1 diabetes patients. (C) 2018 Published by Elsevier Inc.