Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Lok Hin Law, Jianpan Huang, Peng Xiao, Yang Liu, Zilin Chen, Joseph H. C. Lai, Xiongqi Han, Gerald W. Y. Cheng, Kai-Hei Tse, Kannie W. Y. Chan
Summary: Image guided nose-to-brain drug delivery is a non-invasive method to monitor drug delivery to the brain. This study investigated the imaging of liposome-based drug delivery to the brain using chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI). Liposomes loaded with a computed tomography (CT) contrast agent were administered intranasally and specific CEST contrasts were observed in the olfactory bulb and frontal lobe.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Carola Heneweer, Tuula Penate Medina, Robert Tower, Holger Kalthoff, Richard Kolesnick, Steven Larson, Oula Penate Medina
Summary: The study demonstrates that the release ability of sphingomyelin liposomes in liposomal delivery is affected by treatment with sphingomyelinase enzyme, which can make the liposomes leakier and sensitive to cellular stress. Under radiation-induced stress, the targeting ability of liposomes is enhanced, with a higher concentration of released fluorescent markers found at cancer sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Kaiqi Long, Yang Yang, Wen Lv, Kuan Jiang, Yafei Li, Amy Cheuk Yin Lo, Wai Ching Lam, Changyou Zhan, Weiping Wang
Summary: Retinoblastoma is a severe ocular disease that is typically treated with repetitive intravitreal injections of chemotherapeutics. However, a new study has introduced a photoresponsive drug release system that can potentially enhance drug accumulation in the eye through light-triggered intravenous injections of drug-loaded nanocarriers. This proof-of-concept study may pave the way for the development of improved treatment options for eye diseases using light-triggered drug release systems.
Article
Chemistry, Multidisciplinary
Nisha Chander, Johannes Morstein, Jan S. Bolten, Andrej Shemet, Pieter R. Cullis, Dirk Trauner, Dominik Witzigmann
Summary: Incorporation of photoswitchable-phosphatidylcholine analogs in conventional lipid nanoparticles can generate photoactivatable LNPs, allowing light-induced drug release at specific sites, which shows promising potential for clinical development.
Article
Chemistry, Medicinal
Masato Maruyama, Haruka Tojo, Keita Toi, Yusuke Ienaka, Kenji Hyodo, Hiroshi Kikuchi, Ken-ichi Ogawara, Kazutaka Higaki
Summary: The effect of doxorubicin release rates from PEG-liposomes on anti-tumor activity was investigated. The study showed that liposomes with a moderate release rate exhibited the highest anti-tumor activity, which was correlated with the distribution of the drug in cancer cells.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Keni Yang, Karolina Tran, Anna Salvati
Summary: Ideal drug carriers should maintain stability in biological environments and release drugs once inside targeted cells. However, balancing these two aspects can be challenging. This study combined kinetic studies, aging experiments, and chromatography to determine drug release profiles in biological environments and cells, using liposomes as model nanomedicines. The results demonstrated that liposome stability and intracellular release kinetics could be controlled by changing the lipid composition.
Article
Chemistry, Medicinal
Michael Flanagan, Qi Gan, Saahil Sheth, Rachel Schafer, Samuel Ruesing, Linda E. Winter, Karoly Toth, Silviya P. Zustiak, Adriana M. Montano
Summary: Morquio A disease is a genetic disorder caused by GALNS deficiency, and patients are treated with enzyme replacement therapy. This study explored PEG hydrogels as a drug delivery system for sustained release of rhGALNS. The optimized hydrogel formulation achieved sustained release of active rhGALNS for up to 28 days in vitro and up to 20 days in vivo, suggesting that PEG hydrogels could be a promising method for improving patient quality of life.
Article
Pharmacology & Pharmacy
Hisako Ibaraki, Akihiro Takeda, Naoki Arima, Naruhiro Hatakeyama, Yuuki Takashima, Yasuo Seta, Takanori Kanazawa
Summary: The study investigated the effects of different surface modifications on the accumulation of nanocarriers at inflammation sites, revealing that PEG modification and surface charge impact the accumulation of liposomes in inflammatory tissues and uptake by macrophages.
Article
Chemistry, Multidisciplinary
Thomashire A. George, Max M. Chen, Andreas Czosseck, Hsiang-Pei Chen, Hsu-Shan Huang, David J. Lundy
Summary: Triple negative breast cancer (TNBC) is a highly aggressive subtype that is challenging to treat, with small molecule-based chemotherapy being the preferred course of treatment. However, these drugs have high toxicity and tumors may develop resistance.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Na Liu, Fan Fan, Wei Xu, Hao Zhang, Qi Zhou, Xiaopeng Li
Summary: Hollow structured WS2 particles with large surface area were utilized for drug delivery, requiring surface modification and drug loading. Various analyses confirmed the loading and release of PEG and DOX, while the specific surface area was determined. The drug release and biocompatibility were studied with liver tumor cells.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Biophysics
Chih-Wei Ting, Ya-Hsuan Chou, Shih-Yu Huang, Wen-Hsuan Chiang
Summary: In this study, hybrid polymeric nanoparticles carrying ICG were fabricated to improve the anticancer efficacy of ICG-mediated photothermal therapy by accelerating ICG release through pH-responsive mechanisms and increasing the aqueous photostability of ICG molecules. The nanoparticles demonstrated efficient cellular uptake and rapid intracellular liberation of ICG, enhancing the anticancer effect of ICG-mediated PTT.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Yi Jie Eng, Jin Xu, Sigit Sugiarto, Umesh Sai Jonnalagadda, Wendy Ang, Jim Huai-Chin Lee, James J. Kwan, Tuan Minh Nguyen
Summary: The study reports a serendipitously discovered initiator-free photohydrogelation of linear poly(ethylene glycols) containing coumarin and methacrylate end groups, involving a 3-reaction, 1-step process. The role of PEGs in the reaction is elucidated, and a range of hydrogels with good yields are prepared using different molecular weights of coumarin-containing PEG methacrylates. The gels can be partially broken down under ultrasound triggers, and the photodimers in polymer solution are shown to return to their original state in response to ultrasound.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Applied
Vahid Zeyni, Soheyla Karimi, Hassan Namazi
Summary: In this study, a zinc-based metal-organic framework/magnetic hydroxyapatite nanocomposite was synthesized and coated with a biocompatible layer of polyethylene glycol as a targeting drug delivery system. The nanocomposites were characterized and utilized as carriers to encapsulate the anticancer drug doxorubicin. Both nanocomposites showed pH-dependent drug release and the Korsmeyer-Peppas model was the best fit to describe the release mechanism. The synthesized systems showed no significant toxicity and exhibited higher toxicity against lung cancer cell lines. Additionally, the nanocomposites demonstrated excellent antioxidant activity. These findings suggest that the prepared drug systems have potential for targeted drug delivery applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Materials Science, Ceramics
Mohammad Poorhossein, Fatemehsadat Pishbin, Abolghasem Ataie, Mohammad Akrami
Summary: Magnetic nanoparticles can improve the delivery of anticancer drugs to tumor sites while reducing side effects. This research examined the effects of polyethylene glycol (PEG) on the structure, size, morphology, magnetic properties, and coating of cobalt ferrite nanoparticles (CFO). The results showed that higher molecular weight PEG created a thicker coating on the nanoparticles, resulting in higher drug loading efficiency.
CERAMICS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Shirin Tavakoli, Jooseppi Puranen, Sina Bahrpeyma, Veera E. Lautala, Suvi Karumo, Tatu Lajunen, Eva M. del Amo, Marika Ruponen, Arto Urtti
Summary: Choroidal neovascularization (CNV) is a common vascular disorder that affects vision in the elderly population. In this study, sunitinib-loaded liposomes were developed to block the signaling pathway of neovascularization by inhibiting the tyrosine kinase of vascular endothelial growth factor receptors (VEGFRs). The liposomes effectively encapsulated sunitinib and released it over a period of at least 3 days. Compared to the solubilized form, intravitreal injection of sunitinib-loaded liposomes showed promising efficacy in inhibiting CNV associated with age-related macular degeneration (AMD).
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Amir Sadeghi, Marika Ruponen, Jooseppi Puranen, Shoupeng Cao, Roxane Ridolfo, Shirin Tavakoli, Elisa Toropainen, Tatu Lajunen, Veli-Pekka Ranta, Jan van Hest, Arto Urtti
Summary: This study investigates the pharmacokinetics of nanomaterials in the eyes of rats and rabbits. The impact of particle size and shape on ocular distribution and elimination was examined using various imaging techniques. The results show that differently sized particles have different retention times and elimination rates, suggesting that factors other than size also play a role in their kinetics. The study also demonstrates the importance of synchronized particle retention and drug release rate for efficient drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Zehua Liu, Wenhua Lian, Qiang Long, Ruoyu Cheng, Giulia Torrieri, Baoding Zhang, Artturi Koivuniemi, Mohammad Mahmoudzadeh, Alex Bunker, Han Gao, Hongbin He, Yun Chen, Jouni Hirvonen, Rongbin Zhou, Qiang Zhao, Xiaofeng Ye, Xianming Deng, Helder A. Santos
Summary: This study presents a method for preparing ligand-free targeted nanoparticles (NPs) for the heart, and demonstrates their potential for improving cardiac ischemic/reperfusion (I/R) injury.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Paper & Wood
Vili-Veli Auvinen, Patrick Lauren, Boxuan Shen, Jussi Isokuortti, Nikita Durandin, Tatu Lajunen, Veikko Linko, Timo Laaksonen
Summary: Anionic nanocellulose hydrogels were found to be versatile platforms for sustained release of various nanoparticles, with drug release rates depending on nanoparticle size, shape, and charge. Smaller neutral particles were released faster, while cationic particles were retained in the hydrogels.
Article
Biochemistry & Molecular Biology
Franziska Ragaller, Luca Andronico, Jan Sykora, Waldemar Kulig, Tomasz Rog, Yagmur Balim Urem, Abhinav, Dmytro I. I. Danylchuk, Martin Hof, Andrey Klymchenko, Mariana Amaro, Ilpo Vattulainen, Erdinc Sezgin
Summary: The plasma membrane, a complex organelle in cells, plays a crucial role in various cellular processes. Understanding its biophysical properties is important for comprehending biological processes. In this study, different probes were characterized and their sensitivity to various membrane properties was examined. The findings provide a toolbox for selecting the appropriate probe for specific research questions.
Article
Multidisciplinary Sciences
Eija Maki-Mikola, Patrick Lauren, Natsumi Uema, Kanako Kikuchi, Yuuki Takashima, Timo Laaksonen, Tatu Lajunen
Summary: This study established a perfusion cell culture platform to investigate the effects of flow on the uptake of light-activated liposomes by A549 lung cancer cells. Optimal cell culturing parameters were determined by monitoring cell viability, and flow cytometry was used to measure particle uptake for determining optimal liposome treatment times. The suitability of commercial QuasiVivo flow-chambers for light activation studies was assessed.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Saara Lautala, Riccardo Provenzani, Ilari Tarvainen, Katia Sirna, S. Tuuli Karhu, Evgeni Grazhdankin, Antti K. Lehtinen, Hanan Sa'd, Artturi Koivuniemi, Henri Xhaard, Raimo K. Tuominen, Virpi Talman, Alex Bunker, Jari Yli-Kauhaluoma
Summary: Protein kinase C (PKC) modulators have therapeutic potential for various diseases. Targeting the C1 domain of PKC is a promising strategy, but the penetration of the lipid membrane complicates drug design. Molecular dynamics (MD) simulations with PKC, ligands, and membranes have been used to address these challenges. Here, we present the design, synthesis, and evaluation of new PKC agonists using an enhanced workflow with ligand-membrane MD simulations, which could be beneficial in designing ligands for weakly membrane-associated proteins.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Astronomy & Astrophysics
B. E. Robertson, S. Tacchella, B. D. Johnson, K. Hainline, L. Whitler, D. J. Eisenstein, R. Endsley, M. Rieke, D. P. Stark, S. Alberts, A. Dressler, E. Egami, R. Hausen, G. Rieke, I. Shivaei, C. C. Williams, C. N. A. Willmer, S. Arribas, N. Bonaventura, A. Bunker, A. J. Cameron, S. Carniani, S. Charlot, J. Chevallard, M. Curti, E. Curtis-Lake, F. D'Eugenio, P. Jakobsen, T. J. Looser, N. Lutzgendorf, R. Maiolino, M. V. Maseda, T. Rawle, H. -W. Rix, R. Smit, H. Ubler, C. Willott, J. Witstok, S. Baum, R. Bhatawdekar, K. Boyett, Z. Chen, A. de Graaff, M. Florian, J. M. Helton, R. E. Hviding, Z. Ji, N. Kumari, J. Lyu, E. Nelson, L. Sandles, A. Saxena, K. A. Suess, F. Sun, M. Topping, I. E. B. Wallace
Summary: Surveys with the JWST have found candidate galaxies in the first 400 Myr of cosmic time, which may be more massive and abundant than previously thought. However, without confirmed distances, their properties remain uncertain.
Article
Astronomy & Astrophysics
Emma Curtis-Lake, Stefano Carniani, Alex Cameron, Stephane Charlot, Peter Jakobsen, Roberto Maiolino, Andrew Bunker, Joris Witstok, Renske Smit, Jacopo Chevallard, Chris Willott, Pierre Ferruit, Santiago Arribas, Nina Bonaventura, Mirko Curti, Francesco D'Eugenio, Marijn Franx, Giovanna Giardino, Tobias. J. Looser, Nora Lutzgendorf, Michael. Maseda, Tim Rawle, Hans-Walter Rix, Bruno Rodriguez del Pino, Hannah Ubler, Marco Sirianni, Alan Dressler, Eiichi Egami, Daniel. J. Eisenstein, Ryan Endsley, Kevin Hainline, Ryan Hausen, Benjamin. D. Johnson, Marcia Rieke, Brant Robertson, Irene Shivaei, Daniel. P. Stark, Sandro Tacchella, Christina. C. Williams, Christopher N. A. Willmer, Rachana Bhatawdekar, Rebecca Bowler, Kristan Boyett, Zuyi Chen, Anna de Graaff, Jakob. M. Helton, Raphael. E. Hviding, Gareth. C. Jones, Nimisha Kumari, Jianwei Lyu, Erica Nelson, Michele Perna, Lester Sandles, Aayush Saxena, Katherine. A. Suess, Fengwu Sun, Michael. W. Topping, Imaan E. B. Wallace, Lily Whitler
Summary: As part of the JWST Advanced Deep Extragalactic Survey (JADES), NIRSpec has confirmed spectroscopically four young and metal-poor galaxies at redshift 10.3-13.2, from an early epoch of galaxy formation. Spectroscopic confirmation and analysis of four galaxies unambiguously detected at redshift 10.3 <= z <= 13.2 demonstrate the rapid emergence of the first generations of galaxies at cosmic dawn.
Article
Astronomy & Astrophysics
Sandro Tacchella, Daniel J. Eisenstein, Kevin Hainline, Benjamin D. Johnson, William M. Baker, Jakob M. Helton, Brant Robertson, Katherine A. Suess, Zuyi Chen, Erica Nelson, David Puskas, Fengwu Sun, Stacey Alberts, Eiichi Egami, Ryan Hausen, George Rieke, Marcia Rieke, Irene Shivaei, Christina C. Williams, Christopher N. A. Willmer, Andrew Bunker, Alex J. Cameron, Stefano Carniani, Stephane Charlot, Mirko Curti, Emma Curtis-Lake, Tobias J. Looser, Roberto Maiolino, Michael V. Maseda, Tim Rawle, Hans-Walter Rix, Renske Smit, Hannah uebler, Chris Willott, Joris Witstok, Stefi Baum, Rachana Bhatawdekar, Kristan Boyett, A. Lola Danhaive, Anna de Graaff, Ryan Endsley, Zhiyuan Ji, Jianwei Lyu, Lester Sandles, Aayush Saxena, Jan Scholtz, Michael W. Topping, Lily Whitler
Summary: We present JWST NIRCam nine-band near-infrared imaging of the luminous z = 10.6 galaxy GN-z11 from the JWST Advanced Deep Extragalactic Survey of the GOODS-N field. We find a spectral energy distribution (SED) entirely consistent with the expected form of a high-redshift galaxy: a clear blue continuum from 1.5 to 4 mu m with a complete dropout in F115W. The core of GN-z11 is extremely compact in JWST imaging.
ASTROPHYSICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Ruifeng Wang, Xin Shi, Kaikai Li, Alex Bunker, Chunmei Li
Summary: One distinguishing feature of the persimmon is its high proanthocyanidins content, known as persimmon tannin (PT), which has many health benefits. This review aims to summarize the literature on the relationship between PT structure and activity, as well as the potential mechanisms underlying its health benefits. The unique structure of PT and its conversion into oligomeric proanthocyanidins, along with its effects on lipogenic and inflammatory signaling pathways, fatty acid oxidation, gut microbiota, and absorption properties, contribute to its multiple health benefits.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Eva Ramsay, Tatu Lajunen, Madhushree Bhattacharya, Mika Reinisalo, Kirsi Rilla, Heidi Kidron, Tetsuya Terasaki, Arto Urtti
Summary: Retinal drug delivery is challenging due to anatomical and physiological barriers, resulting in limited bioavailability. Current methods like intravitreal injections have limitations for different types of drugs. Selective delivery technologies for retinal drug delivery are not well studied, but they hold promise for cell-specific drug delivery in the eyes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, Research & Experimental
Puja Gangurde, Mohammad Mahmoudzadeh, Zahra Gounani, Artturi Koivuniemi, Patrick Lauren, Tatu Lajunen, Timo Laaksonen
Summary: This study investigated the impact of different lipids on cationic light-activated liposomes and found that selecting the appropriate lipids is crucial for achieving stable and responsive liposomes.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Josef Kehrein, Ekinsu Gursoz, Matthew Davies, Robert Luxenhofer, Alex Bunker
Summary: Amphiphilic ABA-triblock copolymers can solubilize poorly water-soluble molecules and form micelles with high drug loading. Molecular dynamics simulations were conducted to investigate the structure-property relationships of curcumin-loaded micelles. The results showed that the system with the highest experimental loading capacity had the most drug molecules encapsulated by the core. Polymer-drug interactions and the variation in polymer structures were also analyzed.
Article
Chemistry, Medicinal
Janika Jantti, Tuomo Viitaja, Julia Sevon, Tatu Lajunen, Jan-Erik Raitanen, Cordula Schlegel, Mira Viljanen, Riku O. Paananen, Jukka Moilanen, Marika Ruponen, Filip. S. Ekholm
Summary: Dry eye disease is a common ocular disorder that affects millions of people annually. Research suggests that a new liposomal formulation may hold promise in treating DED, showing good evaporation resistance and a promising safety and efficacy profile in vitro. Further preclinical in vivo studies are needed to fully assess and validate its potential in DED treatment.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
