Article
Biochemistry & Molecular Biology
Ionela Cristina Nica, Miruna S. Stan, Roua G. Popescu, Nicoleta Nicula, Robert Ducu, Lucian Diamandescu, Anca Dinischiotu
Summary: Advancements in nanotechnology have led to the development of novel TiO2-based nanomaterials that are widely used in industry and biomedicine. Concerns have been raised about human exposure and cytotoxic effects associated with the increased use of engineered nanomaterials in industry. Research has shown that long-term exposure to TiO2 nanoparticles co-doped with iron and nitrogen can lead to disruptions in the cell cycle and lysosomal membrane permeabilization, triggering apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Batakrishna Jana, Seongeon Jin, Eun Min Go, Yumi Cho, Dohyun Kim, Sangpil Kim, Sang Kyu Kwak, Ja-Hyoung Ryu
Summary: Lysosomes are important organelles and targets for cancer therapy. Recent studies have shown that lysosomal membrane permeabilization can induce cell death, providing an effective way to treat cancer. However, most lysosome-targeted anticancer drugs lack selectivity for cancer cells. This study demonstrates the use of intra-lysosomal self-assembly of a peptide amphiphile as a powerful technique to overcome this problem. The peptide amphiphile localizes in the cancer lysosome and undergoes enzyme-instructed supramolecular assembly, leading to lysosomal damage and caspase-independent apoptotic death of cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Po Hu, Hui Li, Wenzhuo Sun, Hongzheng Wang, Xiaoxuan Yu, Yingjie Qing, Zhanyu Wang, Mengyuan Zhu, Jingyan Xu, Qinglong Guo, Hui Hui
Summary: LW-218 induced rapid lysosomal enlargement and permeabilization, leading to cell death mediated by cathepsin D. Lysophagy was initiated for self-rescue post-treatment, associated with calcium release and transcription factor EB nuclei translocation. Long-term exposure to LW-218 exhausted lysosomal capacity and inhibited normal autophagy.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cell Biology
Mateus Milani, Philippe Pihan, Claudio Hetz
Summary: Calcium is a crucial messenger in regulating cellular processes and interorganelle communication. Lysosomal function is dependent on calcium, and ion channels on the lysosomal membrane regulate lysosomal properties such as pH. Lysosome-dependent cell death (LDCD) is a specific type of cell death involving lysosomes that plays important roles in tissue homeostasis, development, and pathology. This article focuses on recent advances in understanding the role of calcium signaling in LDCD.
Article
Biochemistry & Molecular Biology
Willa Wen-You Yim, Hayashi Yamamoto, Noboru Mizushima
Summary: Damaged lysosomes can be repaired by the calcium release-dependent recruitment of the ESCRT machinery. However, the involvement of annexins in this process has not been fully understood. This study shows that ANXA1 and ANXA2 are important for the repair of damaged lysosomes, and their recruitment is calcium-dependent and independent of the ESCRT mechanism.
Article
Immunology
Yuting Wang, Wenjie Xi, Xinyi Zhang, Xinwen Bi, Boyang Liu, Xiaoming Zheng, Xinjin Chi
Summary: Acute kidney injury is a common and severe complication of sepsis, and the underlying mechanisms are poorly understood. This study established mouse models and in vitro cell models to investigate the role of lysosomal membrane permeabilization (LMP) and cathepsin B (CTSB) in sepsis-induced acute kidney injury (S-AKI). The results suggest that inhibiting CTSB activity may be a potential therapeutic strategy for alleviating S-AKI.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Lucille Ferret, Karla Alvarez-Valadez, Jennifer Riviere, Alexandra Muller, Natalia Bohalova, Luo Yu, Lionel Guittat, Vaclav Brazda, Guido Kroemer, Jean-Louis Mergny, Mojgan Djavaheri-Mergny
Summary: Guanine-quadruplex structures (G4) are formed by guanine-rich DNA and RNA sequences and control gene expression mechanisms. G4 ligands have been developed for potential therapeutic applications in human diseases. Recent evidence suggests that G4 ligands may target cellular components such as lysosomes and mitochondria.
Review
Cell Biology
Saara Hamalisto, Jonathan Stahl-Meyer, Marja Jaaettela
Summary: Mitosis, a tightly regulated process in mammalian life, can still result in errors leading to chromosomal instabilities and malignancies. Recent discoveries have shown unexpected roles for autophagy and lysosomes in preserving genomic integrity during mitosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Rafaela Indalecio Moreno, Vanessa O. Zambelli, Gisele Picolo, Yara Cury, Andre C. Morandini, Antonio Carlos Marques, Juliana Mozer Sciani
Summary: Neuroinflammation, a condition associated with dementia such as Alzheimer's disease, can be caused by an inflammatory response to amyloid peptides. This study identified new caspase-1 and cathepsin B inhibitors from Brazilian marine invertebrates. The extract of the box jellyfish Chiropsalmus quadrumanus was found to inhibit caspase-1, and trigonelline was identified as the active molecule. Additionally, betaine from Exaiptasia diaphana was shown to inhibit cathepsin B. These new prototypes may provide potential targets for enzyme inhibition and control of neuroinflammation.
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Dmitry V. Zaretsky, Maria V. Zaretskaia, Yaroslav I. Molkov
Summary: Alzheimer's disease, the most common cause of dementia, is caused by neuronal death initiated by amyloid-beta peptides. This study proposes the amyloid degradation toxicity hypothesis, which explains the cellular toxicity of amyloid through the formation of non-selective membrane channels in lysosomal membranes. The formation of these channels is promoted in an acidic environment, leading to cell death.
NEUROSCIENCE LETTERS
(2022)
Article
Immunology
Jianhua Wang, Lichun Wang, Xiaofei Zhang, Yanfen Xu, Lei Chen, Weiyu Zhang, Enhe Liu, Chaoxing Xiao, Qiuye Kou
Summary: The study demonstrates that CTSB may exacerbate AP by activating the NLRP3 inflammasome and promoting Caspase-1-induced pyroptosis. Inhibiting CTSB not only reduces pancreatic inflammation but also suppresses the expression and activity of other inflammatory factors related to AP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Indranil Basak, Rachel A. Hansen, Michael E. Ward, Stephanie M. Hughes
Summary: Batten disease, particularly the CLN5 form, results from mutations in the CLN5 gene and leads to neurodegeneration. Research on CLN5-deficient human neurons has shown defects in lysosomes and impaired lysosomal movement, shedding light on the underlying lysosomal pathology in neurodegenerative diseases.
Article
Neurosciences
Ki-Ryeong Kim, Sang Eun Park, Ji-Ye Hong, Jae-Young Koh, Dong-Hyung Cho, Jung Jin Hwang, Yang-Hee Kim
Summary: This study reveals that zinc can activate autophagy and lysosomes, promoting the treatment of neurodegenerative diseases through the regulation of transcription factor EB and V-ATPase. Zinc activates lysosomal proteases and lysosomal acidification, reducing protein aggregation and phosphorylation of tau protein, demonstrating its potential therapeutic effect.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Tsutomu Tanaka, Blake M. Warner, Drew G. Michael, Hiroyuki Nakamura, Toshio Odani, Hongen Yin, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini
Summary: In patients with SS (Sjogren's syndrome), increased expression of LAMP3 has been associated with increased apoptosis and accumulation of autoantigens. Studies showed that LAMP3 expression led to lysosomal membrane permeabilization, affecting autophagic flux and caspase activation. This highlights the significant role of LAMP3 expression in the pathogenesis of SS.
Article
Chemistry, Physical
Vivien Gatard, Deborah De Masi, Raphael Chattot, Irene Mustieles Marin, Juan Manuel Asensio Revert, Pier-Francesco Fazzini, Thierry Encinas, Vincent Martin, Stephane Faure, Jonathan Deseure, Julian Carrey, Bruno Chaudret, Marian Chatenet
Summary: This study focused on investigating different catalysts for oxygen evolution and hydrogen evolution reactions by recording cyclic voltamperograms. Ni and FeNi3 were found to be good catalysts for HER and OER. Electrochemical tests under alternating magnetic field are being conducted to explore the compatibility of these catalysts with AMF activation.
Article
Physics, Applied
Stephane Faure, Sumeet S. Kale, Nicolas Mille, Simon Cayez, Thibault Ourlin, Katerina Soulantica, Julian Carrey, Bruno Chaudret
Summary: The Sabatier reaction activated by high-frequency magnetic fields shows promise for a cheap and efficient chemical energy storage process. Utilizing a combination of iron microparticles and Ni/CeO2 catalyst, as well as enhancing heating efficiency through eddy currents, can effectively improve catalyst durability and energy efficiency.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
A. Rousseau, M. Tellier, L. Marin, M. Garrow, C. Madelaine, N. Hallali, J. Carrey
Summary: This study focuses on the heating and killing of cancer cells using magnetic nanoparticles in a high frequency alternating magnetic field. The specific absorption rate (SAR) of magnetic nanobeads (MNBs) was determined by measuring their high-frequency hysteresis loops. The study found that medium viscosity affects the heating power of MNBs containing superparamagnetic nanoparticles.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Gastroenterology & Hepatology
Remi Samain, Alexia Brunel, Thibault Douche, Marjorie Fanjul, Stephanie Cassant-Sourdy, Julia Rochotte, Jerome Cros, Cindy Neuzillet, Jerome Raffenne, Camille Duluc, Aurelie Perraud, Jeremy Nigri, Veronique Gigoux, Ivan Bieche, Matteo Ponzo, Gilles Carpentier, Ilaria Cascone, Richard Tomasini, Herbert A. Schmid, Muriel Mathonnet, Remy Nicolle, Marie-Pierre Bousquet, Yvan Martineau, Stephane Pyronnet, Christine Jean, Corinne Bousquet
Summary: The study suggests that SOM230 has the potential to be an effective anti-metastatic therapy in PDA by regulating stromal activities, reducing inflammatory responses, and improving the immunosuppressive tumor microenvironment. This pharmacotherapy shows promise in reshaping the tumor environment and enhancing treatment outcomes for pancreatic cancer patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Instruments & Instrumentation
N. Mille, S. Faure, M. Estrader, D. Yi, J. Marbaix, D. De Masi, K. Soulantica, A. Millan, B. Chaudret, J. Carrey
Summary: Magnetic heating using magnetic nanoparticles excited with a high-frequency magnetic field has been utilized for biological applications and catalyzing chemical reactions at high temperatures. Understanding the temperature dependence of heating power of MNPs up to high temperatures is crucial for exploiting their properties fully. A setup for measuring these properties on solid state samples up to 550 degrees C is described, with the potential to reach up to 900 degrees C. This setup is valuable for characterizing MNPs for catalysis applications and generating data for predicting the temperature dependence of MNP heating power.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2021)
Article
Physics, Applied
N. Mille, D. De Masi, S. Faure, J. M. Asensio, B. Chaudret, J. Carrey
Summary: In this study, the dynamics of chain formation in magnetic nanoparticles under applied magnetic fields were probed using time-resolved high-frequency hysteresis loops. The formation time of chains was found to strongly depend on the magnetic field amplitude, but not on the frequency studied. Both heating power and hysteresis loop squareness increase with time as chains form.
APPLIED PHYSICS LETTERS
(2021)
Article
Nanoscience & Nanotechnology
Juan Carlos Camacho-Fernandez, Genesis Karendash Gonzalez-Quijano, Childerick Severac, Etienne Dague, Veronique Gigoux, Jaime Santoyo-Salazar, Adrian Martinez-Rivas
Summary: The study investigated the impact of magnetic nanoparticles interacting with HeLa cells under high frequency alternating magnetic field. It was found that these interactions modified the biomechanical behavior of the cell interfaces, particularly with Fe3O4@SiO2-NH2 MNPs incubated HeLa cells exposed to AMF showing the most significant difference in elasticity and stiffness.
Article
Chemistry, Multidisciplinary
Arnaud Hillion, Nicolas Hallali, Pascal Clerc, Sara Lopez, Yoann Lalatonne, Camille Nous, Laurence Motte, Veronique Gigoux, Julian Carrey
Summary: This study utilizes a miniaturized electromagnet to observe cells specifically targeted by superparamagnetic nanoparticles under a low-frequency rotating magnetic field. The permeabilization of lysosome membrane and movement of lysosomes towards the nucleus are associated with alterations in cell morphology.
Article
Chemistry, Multidisciplinary
Sara Lopez, Nicolas Hallali, Yoann Lalatonne, Arnaud Hillion, Joana C. Antunes, Nizar Serhan, Pascal Clerc, Daniel Fourmy, Laurence Motte, Julian Carrey, Veronique Gigoux
Summary: By mechanically activating ultra-small superparamagnetic iron oxide nanoparticles with a rotating low-amplitude low-frequency magnetic field, cell death induction in pancreatic cancer-associated fibroblasts was maximized to 34%. The force generated by the nanoparticles inside lysosomes was calculated to be approximately 3 pN, leading to lysosome membrane permeabilization and cell death through a lysosomal pathway dependent on cathepsin-B activity.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Physical
Vivien Gatard, Irene Mustieles Marin, Deborah De Masi, Thierry Encinas, Frederic Charlot, Vincent Martin, Mimoun Aouine, Christophe Geantet, Stephane Faure, Jonathan Deseure, Julian Carrey, Bruno Chaudret, Marian Chatenet
Summary: This study aims to investigate the influence of an electrochemical environment combined with an alternating magnetic field (AMF) on FeNi3@Ni nanoparticles. The effect of the aggressive alkaline environment and temperature on the catalysts was studied using in situ techniques. The results provide insights into the long-term durability of this catalytic material in AMF-enhanced alkaline water electrolysis.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Carline Chaves-Almagro, Johanna Auriau, Alizee Dortignac, Pascal Clerc, Hubert Lulka, Simon Deleruyelle, Fabrice Projetti, Jessica Nakhle, Audrey Frances, Judit Berta, Veronique Gigoux, Daniel Fourmy, Marlene Dufresne, Anne Gomez-Brouchet, Julie Guillermet-Guibert, Pierre Cordelier, Bernard Knibiehler, Ralf Jockers, Philippe Valet, Yves Audigier, Bernard Masri
Summary: This study investigated the expression and protumoral function of apelin and its receptor APJ in human pancreatic adenocarcinoma. It was found that apelin and APJ were co-expressed by tumor cells in the invasive stage, and apelin promoted cancer cell proliferation, migration, and glucose uptake. Blocking the apelin receptor reduced cancer cell proliferation and pancreatic tumor burden.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
N. Hallali, T. Rocacher, C. Crouzet, J. Beard, T. Douard, A. Khalfaoui, N. Dias Martin, F. Chouzenoux, J. Carrey
Summary: This paper describes a setup capable of generating a rotating or alternating low-frequency magnetic field for biological applications. The setup is based on a six-pole electromagnet and the characteristics of the field can be changed by varying the phase, amplitude, or frequency of the electrical currents. Detailed information on the design and operation is provided for replication. The setup has been used to demonstrate the ability to kill cells through targeted magnetic nanoparticles and low-frequency magnetic fields.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Irene Morales, Rocio Costo, Nicolas Mille, Julian Carrey, Antonio Hernando, Patricia de la Presa
Summary: The behavior of nanoparticles in an AC magnetic field was studied, with 34 nm particles found to form chains unlike other sizes. The magnetic parameters at low (high) fields increase (decrease) with time, and there is a difference in heating efficiency at different temperatures, possibly related to the relaxation mechanisms of nanoparticles.
NANOSCALE ADVANCES
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)