期刊
JOURNAL OF CONTROLLED RELEASE
卷 284, 期 -, 页码 103-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2018.05.040
关键词
Ultrasound; Starch; miR-197; Psoriasis; Transdermal; Topical gene delivery
资金
- Kamin (Office of the Chief Scientist, Israel) [51401, 51402]
- Israel Science Foundation (ISF) [722/15]
- Israel Ministry of Health [3-10132]
Psoriasis is a common, worldwide autoinflammatory, incurable skin disease. miR-197 has therapeutic potential for psoriasis since it can down-regulate the expression of both IL-22RA1 and IL-17RA, subunits of the receptors of IL-22 and IL-17, respectively, which are key cytokines in the disease. Although miR-197 has the potential to treat the disease, several inherent physical barrier properties of the skin challenge miRNA's delivery to the target skin cells. In the present study, we evaluated a therapeutic approach that combines the use of ultrasound (US) as a means to enhance skin permeability with quaternized starch (Q-starch) as an miRNA delivery carrier. This resulted in decreased expression of the miR-197 target proteins and in a significant reduction in the psoriatic activity markers. Our results demonstrate the potential of combinations of US and Q-starch/miR-197 complexes for the topical skin treatment of psoriasis.
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