Article
Health Care Sciences & Services
Dorota Maria Borowicz, Konstantin N. Shipulin, Gennady V. Mytsin, Agnieszka Skrobala, Piotr Milecki, Victor N. Gayevsky
Summary: Comparison between passive scattering (PS) and intensity-modulated proton therapy (IMPT) for ultra-hypofractionated proton therapy in localized prostate cancer (PCa) showed that IMPT provided better target coverage and lower mean doses to the rectum and bladder compared to PS. However, PS had a slightly better performance in high dose distribution to the rectum. There were no significant differences in mean conformity index values and gamma index between the two treatment methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Otorhinolaryngology
Elizabeth B. Jeans, Satomi Shiraishi, Gohar Manzar, Lindsay K. Morris, Adam Amundson, Lisa A. McGee, Jean-Claude Rwigema, Michelle Neben-Wittich, David M. Routman, Daniel J. Ma, Samir H. Patel, Robert L. Foote, Scott C. Lester
Summary: IMPT is associated with decreased dose to OARs and less patient-reported acute deterioration in multiple head and neck domains. Physician-reported toxicities demonstrated less oral pain. Strong consideration for IMPT in ipsilateral head and neck patients with cancer is warranted.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Medicine, General & Internal
Brian Yu, Sung Jun Ma, Olivia Waldman, Cynthia Dunne-Jaffe, Udit Chatterjee, Lauren Turecki, Jasmin Gill, Keerti Yendamuri, Austin Iovoli, Mark Farrugia, Anurag K. Singh
Summary: This retrospective cohort study found that the use of intensity-modulated radiation therapy (IMRT) for postoperative radiation therapy (PORT) among patients with incompletely resected non-small cell lung cancer (NSCLC) increased in the US from 2004 to 2019. Furthermore, IMRT was associated with improved survival compared with 3D conformal radiation therapy (3DCRT).
Article
Oncology
Jianzhong Cao, Xiaodong Zhang, Bo Jiang, Jiayun Chen, Xiaochun Wang, Li Wang, Narayan Sahoo, X. Ronald Zhu, Rong Ye, Pierre Blanchard, Adam S. Garden, C. David Fuller, G. Brandon Gunn, Steven J. Frank
Summary: The study showed that in patients with oropharyngeal cancer, IMPT treatment was associated with less late xerostomia compared to IMRT treatment. Dosimetric variables related to the oral cavity were associated with late xerostomia.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Sota Nakahara, Takayuki Ohguri, Sho Kakinouchi, Hirohide Itamura, Takahiro Morisaki, Subaru Tani, Katuya Yahara, Naohiro Fujimoto
Summary: This study retrospectively analyzed the efficacy and toxicity of adding regional hyperthermia to intensity-modulated radiotherapy (IMRT) plus neoadjuvant androgen deprivation therapy (ADT) for high-risk localized prostate carcinoma. The results showed that adding hyperthermia improved clinical relapse-free survival and higher thermal dose predicted improved biochemical disease-free survival.
Article
Oncology
Wee Loon Ong, Melanie Davidson, Patrick Cheung, Hans Chung, William Chu, Jay Detsky, Stanley Liu, Gerard Morton, Ewa Szumacher, Chia-Lin Tseng, Danny Vesprini, Ananth Ravi, Merrylee Mcguffin, Liying Zhang, Alexandre Mamedov, Andrea Deabreu, Meghan Kulasingham-Poon, Andrew Loblaw
Summary: This study aimed to correlate dosimetric parameters with toxicities and quality of life outcomes in two-fraction prostate stereotactic ablative radiotherapy (SABR). The results showed that dose parameters of the bladder and penile bulb were associated with toxicities, highlighting the importance of dose constraints in mitigating treatment-related side effects.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Fady Samir, Talaat M. Meaz, Fathi AEl Hussiny, Ahmed A. Ahmed, Amr A. Mahmoud, Tamer Refaat, Ahmed Gawish, Mohamed Abouegylah
Summary: The study compared four techniques in prostate treatment to find the preferred technique. Plans were created for 30 prostate cancer patients using different techniques, and the quality of the plans was assessed by comparing target coverage, organs at risk, monitor units, homogeneity, and conformity among the techniques.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
William T. Hrinivich, Heng Li, Anh Tran, Sahaja Acharya, Matthew M. Ladra, Khadija Sheikh
Summary: Intensity modulated proton therapy provides excellent normal tissue sparing for pediatric cancer treatment, but requires range shifter devices for shallow targets and small anatomy, which increases lateral scatter. This study presents the design, manufacturing, and characterization of a range shifter board that improves normal tissue sparing while minimizing lateral scatter, and compares it to standard range shifter planning approaches. Dosimetric measurements were performed to evaluate the device, and treatment plans from two pediatric patients were compared, showing significant reduction in lung and kidney dose compared to standard range shifter. This device is now in routine use at the clinic.
Article
Oncology
Michelle Oud, Sebastiaan Breedveld, Marta Gizynska, Michiel Kroesen, Stefan Hutschemaekers, Steven Habraken, Steven Petit, Zoltan Perko, Ben Heijmen, Mischa Hoogeman
Summary: This study proposes and evaluates a new approach in intensity modulated proton therapy, which involves the daily selection of plans from patient-specific pre-treatment established plan libraries for treatment. Compared to daily online re-planning, this approach is simpler and reduces the risk of xerostomia and dysphagia, while improving adherence to target coverage constraints.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Eddie Zhang, Karen J. Ruth, Mark K. Buyyounouski, Robert A. Price Jr, Robert G. Uzzo, Mark L. Sobczak, Alan Pollack, J. . Karen Wong, David Y. T. Chen, Mark A. Hallman, Richard E. Greenberg, Deborah Watkins-Bruner, Tahseen Al-Saleem, Eric M. Horwitz
Summary: This study aimed to compare the preservation of erectile function between limiting the doses delivered to the penile bulb and corporal bodies with intensity modulated radiation therapy (IMRT) and standard IMRT in men with prostate cancer. The results showed that there was no significant difference in the preservation of erectile function between the two treatment methods.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Michael Carrasquilla, Tamir Sholklapper, Abigail N. Pepin, Nicole Hodgins, Siyuan Lei, Abdul Rashid, Malika Danner, Alan Zwart, Grecia Bolanos, Marilyn Ayoob, Thomas Yung, Nima Aghdam, Brian Collins, Simeng Suy, Deepak Kumar, Ryan Hankins, Keith Kowalczyk, Nancy Dawson, Sean Collins
Summary: The incidence of failure following IMRT plus SBRT for unfavorable prostate cancer remains low at 5 years.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Valentina Borzillo, Esmeralda Scipilliti, Donato Pezzulla, Marcello Serra, Gianluca Ametrano, Giuseppe Quarto, Sisto Perdona, Sabrina Rossetti, Sandro Pignata, Anna Crispo, Piergiacomo Di Gennaro, Valentina D'Alesio, Cecilia Arrichiello, Francesca Buonanno, Simona Mercogliano, Antonio Russo, Antonio Tufano, Rossella Di Franco, Paolo Muto
Summary: This study retrospectively analyzed the data of low-intermediate-risk prostate cancer patients treated with CyberKnife System SBRT. The results showed that a dose of 35-36.25 Gy yielded excellent control with low toxicity. No differences in biochemical control and overall survival were observed in relation to dose.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Oncology
Darren M. Zuro, Gabriel Vidal, James Nathan Cantrell, Yong Chen, Chunhui Han, Christina Henson, Salahuddin Ahmad, Susanta Hui, Imad Ali
Summary: The purpose of this study is to investigate the treatment planning of TMI using IMPT. The dosimetric parameters of IMPT plans were evaluated and compared with VMAT plans. The results showed significant reduction in organ-at-risk dose in IMPT plans compared to VMAT plans.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
William C. Chen, Yun Li, Ann Lazar, Aysu Altun, Martina Descovich, Tomi Nano, Benjamin Ziemer, Atchar Sudhyadhom, Adam Cunha, Horatio Thomas, Alexander Gottschalk, I-Chow Hsu, Mack Roach III
Summary: This study compared the efficacy and toxicity of prostate cancer patients receiving SBRT boost and HDR boost therapy, showing no significant differences in biochemical recurrence freedom and metastasis freedom between the two treatments, with low toxicity levels.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Editorial Material
Oncology
Cathy J. Bradley, Ya-Chen Tina Shih, K. Robin Yabroff
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Meng Li, Kaiping Liao, Alice J. Chen, Tina Cascone, Yu Shen, Qian Lu, Ya-Chen Tina Shih
Summary: Nationwide, there is evidence to suggest that metastatic lung cancer patients residing in counties with a higher percentage of racialized population experience slower initiation of immune checkpoint inhibitor (ICI) therapy despite having a higher density of medical oncologists in their neighborhood.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Kathrin Milbury, Meagan Whisenant, Shiao-Pei Weathers, Smitha Malliaha, Stella Snyder, Natalie Jackson, Jing Li, Yisheng Li, Roseanglea F. Silva, Ya-Chen Tina Shih, Lorenzo Cohen
Summary: This study compared the effectiveness of dyadic yoga and individual caregiver yoga as supportive care strategies for family caregivers. The results showed that individual caregiver yoga had a greater subjective benefit for caregivers and led to improved mental quality of life and reduced financial burden. This study highlights the importance of individualized support for vulnerable caregiver populations.
Article
Otorhinolaryngology
Houda Bahig, Hanna Y. Y. Ehab, Adam S. S. Garden, Sweet Ping Ng, Steven J. J. Frank, Theresa Nguyen, Gary B. B. Gunn, David I. I. Rosenthal, Clifton D. D. Fuller, Renata Ferrarotto, Diana Bell, Shirley Su, Jack Phan
Summary: This study retrospectively analyzed the long-term outcomes of patients with sinonasal tumors treated with modern radiotherapy. The results showed favorable disease control rate and acceptable toxicity profile in patients treated with modern radiotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Jennifer I. Vidrine, Steven K. Sutton, David W. Wetter, Ya-Chen Tina Shih, Lois M. Ramondetta, Linda S. Elting, Joan L. Walker, Katie M. Smith, Summer G. Frank-Pearce, Yisheng Li, Sarah R. Jones, Darla E. Kendzor, Vani N. Simmons, Damon J. Vidrine
Summary: The purpose of this study was to evaluate the long-term efficacy of Motivation And Problem Solving (MAPS), a novel treatment well-suited to meeting the smoking cessation needs of women who smoke and have a history of cervical intraepithelial neoplasia (CIN) or cervical cancer. It was found that MAPS led to a greater than two-fold increase in smoking abstinence among survivors of CIN and cervical cancer at 12 months, but the effect was no longer significant at 18 months.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Ya-Chen Tina Shih, Cathy Bradley, K. Robin Yabroff
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Mariana Chavez-MacGregor, Xiudong Lei, Catalina Malinowski, Hui Zhao, Ya-Chen Shih, Sharon H. Giordano
Summary: This study used the National Cancer Database to investigate the impact of Medicaid expansion on the timing and delays of adjuvant chemotherapy among early-stage breast cancer patients. The results showed that after Medicaid expansion, the proportion of Black and Hispanic patients experiencing delays in chemotherapy initiation decreased, narrowing the racial disparities.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Vishal R. Patel, Thomas B. Cwalina, Arjun Gupta, Nico Nortje, Samyukta Mullangi, Ravi B. Parikh, Ya-Chen Tina Shih, S. M. Qasim Hussaini
Summary: In this cross-sectional study, oncologist participation and performance in the 2019 MIPS were examined. Oncologist participation rate was found to be low (86%), compared to the overall participation rate (97%). It was also observed that oncologists using alternative payment models (APMs) as their filing source had higher MIPS scores, indicating the importance of organizational resources for participants.
Article
Oncology
Vishal R. Patel, Thomas B. Cwalina, Nico Nortje, Samyukta Mullangi, Ravi B. Parikh, Ya-Chen Tina Shih, Arjun Gupta, S. M. Qasim Hussaini
Summary: The Merit-Based Incentive Payment System (MIPS) is the only federally mandated value-based payment model for oncologists. The inclusion of cost measures in MIPS may disproportionately affect oncologists, who have higher costs of care compared to other specialties. This study examines the implications of incorporating cost measures on physician reimbursements and highlights the need for specialty-specific recalibration to ensure fairness and preserve healthcare quality.
JCO ONCOLOGY PRACTICE
(2023)
Article
Oncology
I-Wen Pan, Tina W. F. Yen, Isabelle Bedrosian, Ya-Chen Tina Shih
Summary: This study examines the trends and associated factors of preoperative breast MRI use among early-stage breast cancer patients. The results show that the use of preoperative breast MRI has steadily increased. In addition to clinical factors, age, race/ethnicity, and geographic location are associated with the use of preoperative MRI.
JCO ONCOLOGY PRACTICE
(2023)
Article
Health Care Sciences & Services
Thanh Cong Bui, Charles E. Hoogland, Chhorvann Chhea, Heng Sopheab, Vichea Ouk, Sovannarith Samreth, Bunleng Hor, Jennife Vidrine, Michael S. Businelle, Ya Chen Tina Shih, Steven K. Sutton, Sarah R. Jones, Bethany Shorey Fennell, Cherell Cottrell-Daniels, Summer G. Frank-Pearce, Chamnab Ngor, Shweta Kulkarni, Damon J. Vidrine
Summary: This paper describes the design, methods, and data analysis plans for a randomized controlled trial assessing the efficacy of a theory-based mobile health smoking cessation intervention in Cambodian people with HIV. By comparing the efficacy of a mobile health-based automated messaging intervention versus standard care, this study has the potential to transform HIV care in Cambodia and prevent tobacco-related diseases.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Oncology
Andrew M. D. Wolf, Kevin C. Oeffinger, Tina Ya-Chen Shih, Louise C. Walter, Timothy R. Church, Elizabeth T. H. Fontham, Elena B. Elkin, Ruth D. Etzioni, Carmen E. Guerra, Rebecca B. Perkins, Karli K. Kondo, Tyler B. Kratzer, Deana Manassaram-Baptiste, William L. Dahut, Robert A. Smith
Summary: Lung cancer is the leading cause of cancer-related deaths and years of life lost in the US. Early detection through screening has been shown to reduce mortality. The American Cancer Society has updated its guidelines for lung cancer screening, recommending annual low-dose CT screening for individuals aged 50-80 who currently smoke or formerly smoked and have a significant smoking history.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Editorial Material
Oncology
Marcelo Coca Perraillon, Ya-Chen Tina Shih
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Tina W. F. Yen, I-Wen Pan, Ya-Chen Tina Shih
Summary: During the COVID-19 pandemic, telehealth use among patients diagnosed with cancer increased, particularly in states with more lenient policies. This study emphasizes the importance of considering telehealth policies that can benefit vulnerable patient populations.
JNCI CANCER SPECTRUM
(2023)
Article
Mathematical & Computational Biology
Shikun Wang, Yu Shen, Ya-Chen Tina Shih, Ying Xu, Liang Li
Summary: Estimating the cost of cancer care is crucial for policymakers. This study proposes a semiparametric approach to estimate the longitudinal cost trajectories of cancer patients by considering survival and longitudinal medical cost data. The proposed method balances model flexibility, statistical efficiency, and computational tractability. The method was used to estimate the cost trajectories of renal cell cancer patients using a linked database.