Article
Endocrinology & Metabolism
Yunpeng Guan, Xiaoyu Hou, Peipei Tian, Luping Ren, Yong Tang, An Song, Jiajun Zhao, Ling Gao, Guangyao Song
Summary: The study investigated mechanisms of postprandial hypertriglyceridemia (PPT) through analyzing serum lipid and apolipoprotein levels before and after a high-fat meal. Results showed significantly higher levels of various parameters in the PPT group, indicating that elevated ApoCIII levels may be a risk factor for PPT.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amirhossein Sahebkar, Zahra Heidari, Zahra Kiani, Masoumeh Atefi, Azadeh Zareie, Mehrnaz Shojaei, Gholamreza Askari, Prashant Kesharwani, Mohammad Bagherniya
Summary: This meta-analysis evaluated the effects of the DASH diet on lipid profiles based on clinical controlled trials. The results showed that following the DASH diet significantly reduced serum triglycerides and low-density lipoprotein cholesterol levels, but had no significant effect on serum total cholesterol and high-density lipoprotein cholesterol levels. Therefore, the DASH diet can be considered as a strategy for the prevention and complementary management of dyslipidemia.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Geriatrics & Gerontology
Yongzheng Lu, Xiaolin Cui, Li Zhang, Xu Wang, Yanyan Xu, Zhen Qin, Gangqiong Liu, Qiguang Wang, Kang Tian, Khoon S. Lim, Chris J. Charles, Jinying Zhang, Junnan Tang
Summary: Dyslipidemia increases the risk of atherosclerosis, and lipoproteins play a significant role in its development. Understanding lipoprotein function can help predict risk and provide novel treatment approaches for atherosclerosis.
Article
Nutrition & Dietetics
Aicha Laouani, Hana Nasrallah, Awatef Sassi, Farhana Ferdousi, Feten Zar Kalai, Yosra Hasni, Khalifa Limem, Hiroko Isoda, Saad Saguem
Summary: In this study, the feasibility, compliance, and potential benefits of Nitraria retusa extract (NRE) intervention were explored in both healthy and overweight/obese adults. Participants were randomly assigned to either a low-dose or a high-dose NRE intervention group. Results showed that the high-dose group of overweight/obese participants experienced a significant decrease in triglyceride levels and an increase in HDL levels. The study demonstrated good compliance and acceptability, with over 90% of participants completing the intervention.
Article
Endocrinology & Metabolism
Alexandra E. Butler, Abu Saleh Md Moin, Zeljko Reiner, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar, Stephen L. Atkin
Summary: Proteomic analysis was conducted to investigate the mechanism of dyslipidemia in women with polycystic ovary syndrome (PCOS), and whether it is related to obesity and insulin resistance (IR) or intrinsic to PCOS. The analysis revealed altered levels of certain proteins associated with lipid metabolism in PCOS women, suggesting increased cardiovascular risk even in the absence of obesity and IR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Babak Roshanravan, Saeed Samarghandian, Milad Ashrafizadeh, Alireza Amirabadizadeh, Farhad Saeedi, Tahereh Farkhondeh
Summary: This study suggests that saffron and crocin may modulate the serum lipid profile in patients with metabolic disorders.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ismael Valladolid-Acebes, Karin Avall, Patricia Recio-Lopez, Noah Moruzzi, Galyna Bryzgalova, Marie Bjornholm, Anna Krook, Elena Fauste Alonso, Madelene Ericsson, Fredrik Landfors, Stefan K. Nilsson, Per-Olof Berggren, Lisa Juntti-Berggren
Summary: Lowering apoCIII can protect against and reverse the metabolic phenotype induced by HFD by promoting physiological insulin sensitivity.
Review
Chemistry, Medicinal
Sahar Dadkhah Tehrani, Mehrnaz Shojaei, Mohammad Bagherniya, Matteo Pirro, Amirhossein Sahebkar
Summary: This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B, while increasing high-density lipoprotein cholesterol levels in HTG patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Patricia Recio-Lopez, Ismael Valladolid-Acebes, Philipp Hadwiger, Markus Hossbach, Monika Krampert, Carla Prata, Per-Olof Berggren, Lisa Juntti-Berggren
Summary: In this study, siRNAs were developed to silence apoCIII in vivo and it was found that this approach can result in metabolic improvements. Reduction of apoCIII expression led to increased LPL activity, lower triglyceride levels, reduced liver fat, ceased weight gain, enhanced insulin sensitivity, and improved glucose homeostasis.
Article
Nutrition & Dietetics
Hwan-Hee Jang, In-Guk Hwang, Young-Min Lee
Summary: This study evaluated the effects of anthocyanin intake on blood lipid levels by analyzing relevant randomized controlled trials. The results showed that anthocyanin supplementation significantly reduced triglyceride and low-density lipoprotein-cholesterol levels, and increased high-density lipoprotein-cholesterol levels. However, larger, well-designed clinical trials are needed to further investigate the effects of anthocyanin intake on blood lipid levels and the safety of anthocyanin supplementation for treating dyslipidemia.
FRONTIERS IN NUTRITION
(2023)
Article
Environmental Sciences
Ziwei Chen, Jing He, Lihua Chen, Xiaohui Wu, Xiaohong Yu
Summary: This study investigated the association between nickel exposure and serum lipid profiles. The findings revealed a linear association between nickel exposure and serum total cholesterol and LDL-C, while a nonlinear association was observed with HDL-C. However, no significant relationship was found between nickel exposure and triglyceride levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
G. B. John Mancini, Arnold Ryomoto, Iulia Iatan, Robert A. Hegele
Summary: The limitations of the Friedewald equation in cases of elevated triglyceride (TG) or low-density lipoprotein-cholesterol (LDL-C) have led to the development of alternative methods such as Martin-Hopkins and Sampson-National Institutes of Health (NIH). A comparison of the three methods across a wide range of total cholesterol (TC), TG, and high-density lipoprotein-cholesterol (HDL-C) levels showed that Sampson-NIH yields similar or lower LDL-C values than Friedewald when TC and TG are high. However, the use of alternate LDL-C values may introduce variability in clinical decisions at commonly used LDL-C levels for treatment stratification. These findings highlight the importance of directly measuring apolipoprotein B or considering non-HDL-C to overcome the limitations of all three methods.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guanghan Fan, Chenzhi Zhang, Xuyong Wei, Rongli Wei, Zhetuo Qi, Kangchen Chen, Xuechun Cai, Li Xu, Linsong Tang, Junbin Zhou, Zhensheng Zhang, Zuyuan Lin, Haiyang Xie, Shusen Zheng, Weimin Fan, Xiao Xu
Summary: This study investigates the mechanism of rapamycin-induced dyslipidemia after liver transplantation by focusing on the role of microRNA hsa-miR-372?3p in regulating triglyceride metabolism through target genes AGPS and APOC4. The results suggest that the NEAT1/hsa-miR-372?3p/AGPS/APOC4 axis plays a crucial role in disrupting lipid homeostasis caused by rapamycin, providing a potential therapeutic target for combating dyslipidemia post-LT.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Xiao Huang, Yan Yang, Yingling Jiang, Zhiguang Zhou, Jingjing Zhang
Summary: This study aimed to determine the relationship between lipid profiles and vitamin D deficiency in overweight and obese adults. The results showed that individuals with vitamin D deficiency had higher levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol, and lower levels of high-density lipoprotein cholesterol.
Article
Endocrinology & Metabolism
Chunyan Hu, Shuangyuan Wang, Lin Lin, Hongyan Qi, Hong Lin, Xiaojing Jia, Yuanyue Zhu, Xueyan Wu, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Weiqing Wang, Guang Ning, Yufang Bi, Donghui Li, Yuhong Chen, Meng Dai, Jieli Lu
Summary: Recent studies have shown that serum Sparcl1 levels are inversely associated with triglycerides and positively associated with high-density lipoprotein cholesterol. Higher Sparcl1 levels are also correlated with a reduced risk of prevalent dyslipidemia in the Chinese population.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mariann Gyongyosi, Pilar Alcaide, Folkert W. Asselbergs, Bianca J. J. M. Brundel, Giovanni G. Camici, Paula da Costa Martins, Peter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepekoylu, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G. Schiattarella, Joost P. G. Sluijter, Sabine Steffens, Carsten Tschope, Sophie Van Linthout, Sean M. Davidson
Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Transplantation
Alberto Ortiz, Francesco Mattace-Raso, Maria Jose Soler, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Medicine, General & Internal
Jean-Baptiste Bonnet, Philippe Couvert, Mathilde Di-filippo, Florian Boissiere, Jean-Paul Cristol, Thibault Sutra, David Cheillan, Philippe Moulin, Ariane Sultan
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Pediatrics
Noel Peretti, Alexandre Vimont, Emmanuel Mas, Jean Ferrieres, Patrick Tounian, Julie Lemale, Franck Boccara, Mathilde Di Filippo, Sybil Charriere, Philippe Moulin, Pierre Poinsot, Yves Cottin, Pierre-Henri Ducluzeau, Caroline Dourmap, Bertrand Cariou, Michel Farnier, Francois Paillard, Alain Pradignac, Cecile Yelnik, Antonio Gallo, Eric Bruckert, Sophie Beliard
Summary: Childhood and parental factors, including genetic diagnosis and parental vascular disease, are associated with the initiation of statin therapy in children with HeFH. Genetic diagnosis may be useful for cardiovascular prevention in children.
JOURNAL OF PEDIATRICS
(2023)
Article
Biochemical Research Methods
Marlene Wiart, Clement Tavakoli, Violaine Hubert, Ines Hristovska, Chloe Dumot, Stephane Parola, Frederic Lerouge, Fabien Chauveau, Emmanuelle Canet-Soulas, Olivier Pascual, David P. Cormode, Emmanuel Brun, Helene Elleaume
Summary: The activation of phagocytic cells is important in neurological diseases, and tracking them in the brain using MRI and CT can help understand their role and monitor therapeutic effects. Metal-based contrast agents like gadolinium, gold, and iron can be used for tracking phagocytic cells, but they may have toxicity and accumulation issues. Despite these challenges, early results in patients with neurological diseases are promising.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Surgery
Chloe Trotzier, Ines Sequeira, Celine Auxenfans, Ali A. Mojallal
Summary: In the past 30 years, autologous fat grafting has been widely used for soft-tissue augmentation and improving facial skin quality. Aging has a negative impact on adipose tissue, leading to a decrease in volume and proliferation of adipose tissue, as well as an increase in fibrosis. Adipose-derived stem/stromal cells (ASCs) have attracted attention due to their regenerative potential, and they have been utilized in fat grafting procedures to enhance graft survival. However, variations in surgical techniques and adipose tissue biology can affect clinical outcomes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Physiology
Charlotte Hiroux, Moniek Schouten, Isabelle de Glisezinski, Chantal Simon, Francois Crampes, Peter Hespel, Katrien Koppo
Summary: Increased protein intake effectively prevents muscle wasting and maintains exercise capacity during a period of caloric restriction in female recreational athletes. Exogenous ketosis does not affect body composition, but shows its potential in weight management by preserving a drop in exercise capacity and resting energy expenditure (REE) and by improving overall stress parameters during a period of caloric restriction.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medical Laboratory Technology
Denis Monneret, Amelie Moreau, Carole Chirica, Dorra Guergour, Caroline Richet, Laurent Desmurs, Sylvie Colognac, Audrey Frugier, Marc Chevrier, Oriane Marmontel, Dominique Bonnefont-Rousselot, Philippe Gonzalo, Claire Rodriguez-Lafrasse, Regine Cartier
Summary: This study aims to investigate the non-linearity and distribution differences in lipase assays on different analysers. By evaluating 18 plasma samples on various analysers, significant non-linearity biases were observed in the Roche Cobas c503 method and the Randox method on the Abbott Alinity.
CLINICAL BIOCHEMISTRY
(2023)
Article
Critical Care Medicine
Louis-Marie Galerneau, Sebastien Bailly, Nicolas Terzi, Stephane Ruckly, Maite Garrouste-Orgeas, Yves Cohen, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Michael Darmon, Jean-Marie Forel, Guillaume Rigault, Christophe Adrie, Dany Goldgran-Toledano, Virginie Laurent, Etienne de Montmollin, Laurent Argaud, Jean Reignier, Jean-Louis Pepin, Jean-Francois Timsit
Summary: The management of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has changed over the past 20 years, with a decrease in the use of corticosteroids and antibiotics, and an increase in the use of noninvasive ventilation (NIV). This has led to a decrease in ICU length of stay and mortality rates.
CRITICAL CARE MEDICINE
(2023)
Article
Anesthesiology
Pascal Chiari, Olivier Desebbe, Michel Durand, Marc-Olivier Fischer, Diane Lena-Quintard, Jean-Charles Palao, Geraldine Samson, Yvonne Varillon, Bernadette Vaz, Pierre Joseph, Arnaud Ferraris, Matthias Jacquet-Lagreze, Matteo Pozzi, Delphine Maucort-Boulch, Michel Ovize, Gabriel Bidaux, Nathan Mewton, Jean-Luc Fellahi
Summary: The ProCCard study aimed to reduce myocardial and clinical damage in patients undergoing cardiac surgery by combining several cardioprotective interventions. However, the study did not demonstrate any biological or clinical benefits in this context.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Anesthesiology
Matthias Jacquet-Lagreze, Faustine Bredeche, Claire Louyot, Matteo Pozzi, Daniel Grinberg, Michele Flagiello, Philippe Portran, Martin Ruste, Remi Schweizer, Jean-Luc Fellahi
Summary: The study aimed to investigate the impact of central arterial pressure monitoring versus radial arterial pressure monitoring on norepinephrine requirements during cardiac surgery. Through an observational prospective cohort study, the authors found that central arterial pressure monitoring was associated with lower norepinephrine use, shorter ICU stay, and decreased adverse events.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Critical Care Medicine
Guillaume Rigault, Claude Guerin, Florian Sigaud, Laurent Argaud, Louis-Marie Galerneau, Nicolas Terzi
Summary: The aim of this study was to compare respiratory parameters and workload across different SBT modalities on a bench. The results showed that, with the same effort intensity and frequency, inspiratory tidal volume was higher in the T-piece modality, while workload was significantly lower in the HFO modality, and higher flow was beneficial. Based on these findings, further clinical testing of HFO as an SBT modality is warranted.
Review
Endocrinology & Metabolism
Mauricio Castro-Sepulveda, Rodrigo Fernandez-Verdejo, Hermann Zbinden-Foncea, Jennifer Rieusset
Summary: Mitochondria-endoplasmic/sarcoplasmic reticulum (ER/SR) interaction and mitochondrial fusion/fission are crucial for substrate oxidation regulation in human skeletal muscle. Evidence suggests that increased mitochondria-SR interaction and mitochondrial fusion are associated with elevated fatty acid oxidation, while decreased mitochondria-SR interaction and increased mitochondrial fission are linked to increased glycolytic activity. These findings support the hypotheses that impaired mitochondria dynamics may lead to insulin resistance and the accumulation of lipids in skeletal muscle.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Letter
Pediatrics
Jean-Charles Picaud
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Diana Santos-Ribeiro, Marylene Lecocq, Michele de Beukelaer, Caroline Bouzin, Mihaly Palmai-Pallag, Yousef Yakoub, Francois Huaux, Sandrine Horman, Frederic Perros, Charles Pilette, Laurent Godinas
Summary: Pulmonary hypertension (PH) is a chronic disorder of the pulmonary circulation that often occurs with other respiratory diseases, and it may lead to right ventricular failure. This study validated an animal model of combined pulmonary fibrosis (PF) and PH, and examined its effects on lung and vascular remodeling as well as right ventricular structure and function. The results showed successful replication of the human disease features in this rat model.
PULMONARY CIRCULATION
(2023)
