期刊
JOURNAL OF CLINICAL LIPIDOLOGY
卷 12, 期 2, 页码 428-436出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2017.12.010
关键词
Gestational hypertension; Preeclampsia; Body mass index; Lipoproteins; Lipids
资金
- Erasmus Medical Center, Erasmus University Rotterdam
- Netherlands Organization for Health Research and Development
- Netherlands Organization for Scientific Research
- Ministry of Health, Welfare and Sport
- Ministry of Youth and Families
- Netherlands Organization for Health Research and Development [90700303, 916.10159, VIDI 016.136.361]
- European Research Council [ERC-2014-CoG-64916]
- Stichting Coolsingel
- Dutch Heart Foundation [2013T083]
BACKGROUND: Gestational hypertensive disorders (GHDs), including gestational hypertension and preeclampsia, are associated with an increased risk of cardiovascular disease in later life, possibly through an atherogenic lipid profile. OBJECTIVE: The objective of this study is to assess if women with a previous GHD have a more atherogenic lipid profile 6 years after pregnancy compared to women with a previous normotensive pregnancy. METHODS: In a population-based prospective cohort study, we included 4933 women during pregnancy, including 302 women with a GHD. Six years after pregnancy, we determined maternal lipid profile (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, lipoprotein[a], and apolipoprotein B) and glucose levels. RESULTS: Women with a previous GHD had a more atherogenic lipid profile 6 years after pregnancy compared to women with a previous normotensive pregnancy. These atherogenic lipid profiles were a result of higher levels of triglycerides, low-density lipoprotein cholesterol, and apolipoprotein B and lower levels of high-density lipoprotein cholesterol.. Differences in lipid profile between women with a previous GHD and women with a previous normotensive pregnancy were attenuated after adjustment for prepregnancy body mass index. Between women from both groups, no differences were observed in total cholesterol, lipoprotein[a], and glucose levels. CONCLUSION: Women with a previous GHD show a more atherogenic lipid profile 6 years after pregnancy than women with a previous normotensive pregnancy. The increased risk of cardiovascular disease after a GHD might result from an atherogenic lipid profile after pregnancy, primarily driven by prepregnancy body mass index. (C) 2018 National Lipid Association. All rights reserved.
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