Article
Health Care Sciences & Services
Funmilola Josephine Haukamp, Eline Gall, Gia-Gia Toni Ho, Wiebke Hiemisch, Florian Stieglitz, Joachim Kuhn, Rainer Blasczyk, Andreas Pich, Christina Bade-Doeding
Summary: Type B adverse drug reactions (ADRs) are unpredictable and pose a key challenge in pharmacovigilance. The interaction between human leukocyte antigen (HLA) and drugs can cause strong T-cell-mediated immune responses. However, the long-term damages of HLA-drug-T cell cooperation following treatment remain unexplained. Proteomic analysis of HLA/drug presenting cells provides valuable insights for individual pharmacovigilance and personalized medication.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Suryatheja Ananthula, Kirthiram Krishnaveni Sivakumar, Marco Cardone, Shan Su, Gregory Roderiquez, Hanan Abuzeineh, David E. Kleiner, Michael A. Norcross, Montserrat Puig
Summary: This study characterizes the immune mechanisms involved in FLX-induced liver injury and highlights the role of HLA-B*57:01 expression, CD4+ cells, and PD-1 expression in modulating CD8+ T-cell responses. Tolerogenic hepatic cells play a protective role through PD-L1 or other unknown mechanisms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Montserrat Puig, Suryatheja Ananthula, Ramesh Venna, Swamy Kumar Polumuri, Elliot Mattson, Lacey M. Walker, Marco Cardone, Mayumi Takahashi, Shan Su, Lisa F. Boyd, Kannan Natarajan, Galina Abdoulaeva, Wells W. Wu, Gregory Roderiquez, William H. Hildebrand, Serge L. Beaucage, Zhihua Li, David H. Margulies, Michael A. Norcross
Summary: The interaction between flucloxacillin (FLX) and HLA-B*57:01 may lead to the formation of neoantigens, causing severe hypersensitivity reactions. FLX treatment diversifies the immunopeptidome of cells, enriching it with drug-modified peptides that induce specific CD8(+) T cell responses. FLX-modified lysines on peptides may impact interactions with KIR or TCR, affecting NK and T cell function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Anuradha Sooda, Francois Rwandamuriye, Celestine N. Wanjalla, Lichen Jing, David M. Koelle, Bjoern Peters, Shay Leary, Abha Chopra, Michael A. Calderwood, Simon A. Mallal, Rebecca Pavlos, Mark Watson, Elizabeth J. Phillips, Alec J. Redwood
Summary: Abacavir may inhibit the recognition of HLA-B*57:01 restricted T cell receptor (TCR) specificity, thus disrupting interactions with pathogen-specific TCRs.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Yuying Gao, Binbin Song, Shigeki Aoki, Kousei Ito
Summary: The interaction between HLA-B*57:01 and the FLX-albumin conjugate may be an important risk factor for FLX-induced liver injury, and patients carrying HLA-B*57:01 may be more susceptible to its effects. The sensitivity of the immune system does not play a decisive role in FLX-induced liver injury.
IMMUNOLOGY LETTERS
(2022)
Article
Pharmacology & Pharmacy
V Kalidasan, Iswarya Kunalan, Reena Rajasuriar, Vijay Kumar Subbiah, Kumitaa Theva Das
Summary: This study assessed the presence of HLA-B*57:01 allele in 152 patients and found that all PLWH tested negative for the allele, indicating that testing for HLA-B*57:01 may not be beneficial for this population.
Article
Biotechnology & Applied Microbiology
Pablo Zubiaur, Miriam Saiz-Rodriguez, Gonzalo Villapalos-Garcia, Marcos Navares-Gomez, Dora Koller, Francisco Abad-Santos
Summary: Abacavir (ABC) can cause severe hypersensitivity reactions in HIV patients, with the HLA-B * 57:01 allele being associated with this reaction. A study found a high concordance between HLA-B * 57:01 and the HCP5 rs2395029 gene, suggesting the latter can be an alternative method for genotype analysis in clinical practice.
PHARMACOGENETICS AND GENOMICS
(2021)
Article
Cell Biology
Funmilola Josephine Haukamp, Zoe Maria Hartmann, Andreas Pich, Joachim Kuhn, Rainer Blasczyk, Florian Stieglitz, Christina Bade-Doeding
Summary: The measurement of drug-mediated immune reactions based on genetic variations is essential for individualized medication protocols since certain patient-specific immune reactions cannot be reliably predicted. Understanding the proteomic state of selected individuals under drug administration is important. Previous studies have analyzed the association between certain HLA molecules and drugs, including carbamazepine (CBZ), but the polymorphic nature of HLA makes broad predictions unfeasible. In this study, the mechanism of HLA-B*57:01-mediated CBZ hypersensitivity was investigated through full proteome analysis, revealing significant proteomic alterations and imbalances in pro- and anti-inflammatory processes.
Editorial Material
Cell Biology
Seik-Soon Khor, Yosuke Omae, Katsushi Tokunaga
Summary: This sentence describes a nucleotide difference at position 1913 in intron 4 between HLA-B*13:01:01:09 and HLA-B*13:01:01:01.
Editorial Material
Cell Biology
Mohammed Alghamdi, Manar A. Aldosari, Abdulrhman Alkhaibari, Abdullah S. Matyuri, Ali H. Hajeer
Summary: Two nucleotide changes in the 3' UTR region of HLA-B*57:02:01:01 lead to the formation of a novel allele, HLA-B*57:02:01:03.
Editorial Material
Cell Biology
Georgios Damianos, Jamie L. Duke, Ioanna Pagkrati, David J. Margolis, Dimitri S. Monos
Summary: DPA1*01:03:01:57 and DPA1*02:01:01:29 differ from their closest references, DPA1*01:03:01:02 and DPA1*02:01:01:06, by a single nucleotide.
Article
Infectious Diseases
Tam Tran Thi Minh, Yuta Hikichi, Shoji Miki, Yuriko Imanari, Shigeru Kusagawa, Midori Okazaki, Thao Dang Thi Thu, Teiichiro Shiino, Saori Matsuoka, Hiroyuki Yamamoto, Jun Ohashi, William W. Hall, Tetsuro Matano, Lan Anh Nguyen Thi, Ai Kawana-Tachikawa
Summary: The protective impact of HLA-B *57:01/58:01 on CRF01_AE infection is impaired despite strong suppressive pressure by TW10-specific CD8+ T cells.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Jackson J. Wallner, Ingrid A. Beck, Nuttada Panpradist, Parker S. Ruth, Humberto Valenzuela-Ponce, Maribel Soto-Nava, Santiago Avila-Rios, Barry R. Lutz, Lisa M. Frenkel
Summary: An inexpensive and easy-to-use rapid assay for detecting HLA-B*57:01 was developed in this study, which is of great significance for patients with HIV infection using ABC treatment.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2021)
Editorial Material
Cell Biology
Elena P. P. Kuzminova, Evgeny A. A. Leonov, Alena R. R. Abdrakhimova, Stanislav P. P. Khizhinskiy, Ekaterina G. G. Khamaganova
Summary: Two new alleles B*18:01:01:74 and C*06:02:01:93 have been identified in Russian individuals.
Editorial Material
Cell Biology
Xuan You, Yanmin He, Bing Dai, Ji He, Faming Zhu
Summary: Compared with HLA-C*01:02:01:01, the alleles HLA-C*01:02:56 and HLA-C*01:02:57 each have one synonymous nucleotide substitution.