期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 128, 期 4, 页码 1355-1370出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI96149
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资金
- Marit and Hans Rausingg's Fund for Cancer Research
- Swedish Cancer Society
- Swedish Research Council-Starget-Linne
- Academy of Finland (Center of Excellence in Cancer Genetics Research)
- Finnish Cancer Foundations
- Sigrid Juselius Foundation
- Radiumhemmet
- KI-AZ Support Grant
- KI-Stockholm County Council
- Swedish Society for Medical Research (SSMF)
- Strategic Research Programme in Cancer (StratCan)
- Breast Cancer Theme Center (BRECT)
Metastatic breast cancers are still incurable. Characterizing the evolutionary landscape of these cancers, including the role of metastatic axillary lymph nodes (ALNs) in seeding distant organ metastasis, can provide a rational basis for effective treatments. Here, we have described the genomic analyses of the primary tumors and metastatic lesions from 99 samples obtained from 20 patients with breast cancer. Our evolutionary analyses revealed diverse spreading and seeding patterns that govern tumor progression. Although linear evolution to successive metastatic sites was common, parallel evolution from the primary tumor to multiple distant sites was also evident. Metastatic spreading was frequently coupled with polyclonal seeding, in which multiple metastatic subclones originated from the primary tumor and/or other distant metastases. Synchronous ALN metastasis, a well-established prognosticator of breast cancer, was not involved in seeding the distant metastasis, suggesting a hematogenous route for cancer dissemination. Clonal evolution coincided frequently with emerging driver alterations and evolving mutational processes, notably an increase in apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like-associated (APOBEC-associated) mutagenesis. Our data provide genomic evidence for a role of ALN metastasis in seeding distant organ metastasis and elucidate the evolving mutational landscape during cancer progression.
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