Article
Geriatrics & Gerontology
Mauro Di Bari, Francesco Tonarelli, Daniela Balzi, Antonella Giordano, Andrea Ungar, Samuele Baldasseroni, Graziano Onder, M. Teresa Mechi, Giulia Carreras
Summary: Vulnerability increases mortality in hospitalized older patients, regardless of COVID-19 status. In nonhospitalized patients, vulnerability-associated excess mortality is milder in individuals with COVID-19. The disease reduces survival even when background risk is low.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Medicine, General & Internal
Prarthna Bhardwaj, Vida Rastegar, Rohini Meka, Khalid Sawalha, Maura Brennan, Mihaela S. Stefan
Summary: The study did not find a relationship between BMI and frailty among hospitalized older adults. However, overweight patients had a survival advantage if they were non-frail or vulnerable. Further longitudinal studies are needed to assess the interaction between frailty and BMI in older adults.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Chukwuma Okoye, Beatrice Arosio, Silvia Carino, Luana Putrino, Riccardo Franchi, Sara Rogani, Matteo Cesari, Daniela Mari, Giovanni Vitale, Alba Malara, Valeria Calsolaro, Fabio Monzani
Summary: This study evaluates the relationship between free triiodothyronine (fT3)/free thyroxine (fT4) ratio value and frailty degree in three different cohorts of older individuals. The study found that the fT3/fT4 ratio is significantly inversely correlated with frailty degree and is associated with a decreased mortality risk.
Article
Geriatrics & Gerontology
Jonathan K. L. Mak, Sara Hagg, Maria Eriksdotter, Martin Annetorp, Ralf Kuja-Halkola, Laura Kananen, Anne-Marie Bostrom, Miia Kivipelto, Carina Metzner, Viktoria Back Jerlardtz, Malin Engstrom, Peter Johnson, Lars Goran Lundberg, Elisabet Akesson, Carina Suhl Oberg, Maria Olsson, Tommy Cederholm, Juulia Jylhava, Dorota Religa
Summary: An electronic frailty index (eFI) developed from electronic health records (EHRs) has strong associations with adverse outcomes in hospitalized older adults, suggesting its potential use in risk stratification.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Chan Mi Park, Gahee Oh, Heayon Lee, Hee-Won Jung, Eunju Lee, Il-Young Jang, Dae Hyun Kim
Summary: A 24-week multicomponent intervention program was associated with a slower progression of disability in socioeconomically vulnerable older adults. However, the association attenuated over time, indicating the need for reassessment and further intervention. The findings should be interpreted with caution due to the lack of randomization.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Review
Oncology
Hongliang Liang, Aiping Hu
Summary: Frailty is associated with poor long-term survival of patients with gastric cancer, according to a systematic review and meta-analysis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Roberta Zupo, Fabio Castellana, Vito Guerra, Rossella Donghia, Ilaria Bortone, Chiara Griseta, Luisa Lampignano, Vittorio Dibello, Madia Lozupone, Helio Jose Coelho-Junior, Vincenzo Solfrizzi, Gianluigi Giannelli, Giovanni De Pergola, Heiner Boeing, Rodolfo Sardone, Francesco Panza
Summary: Preventive nutritional management of frailty may reduce adverse health-related outcomes in older adults. A novel measure combining physical frailty with nutritional imbalance, known as nutritional frailty, was found to be a better predictor of all-cause mortality compared to physical frailty alone or cognitive frailty.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Kees van der Wulp, Marleen H. van Wely, Yvonne Schoon, Priya Vart, Marcel G. M. Olde Rikkert, Wim J. Morshuis, Niels van Royen, Michel W. A. Verkroost, Helmut R. Gehlmann, Leen A. F. M. Van Garsse, Peter C. Kievit
Summary: This study highlights impaired mobility as the best single predictor for postoperative delirium and 2-year mortality in high-risk elderly patients undergoing TAVI. Prospective multicenter studies are needed to further explore and optimize the use of predictors for delirium in TAVI care pathways.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Geriatrics & Gerontology
Junlan Pu, Weijiao Zhou, Wen Zeng, Shaomei Shang
Summary: Long-term trajectories of frailty in older cancer survivors are heterogeneous. This study helps identify patients at high risk of sustained or deteriorating frailty and has the potential to inform targeted frailty management strategies addressing modifiable factors identified.
Article
Medicine, General & Internal
Monica Pizzonia, Chiara Giannotti, Luca Carmisciano, Alessio Signori, Gianmarco Rosa, Federico Santolini, Irene Caffa, Fabrizio Montecucco, Alessio Nencioni, Fiammetta Monacelli
Summary: The study validated the modified 19-item Frailty Index (mFI-19) compared to the gold standard comprehensive geriatric assessment (CGA), finding similar predictive accuracies in long-term mortality. This research provides a methodologically robust frailty screening assessment for older adults with hip fractures.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Geriatrics & Gerontology
Ron M. J. Warnier, Erik van Rossum, Monique F. M. T. Du Moulin, Marjolein van Lottum, Jos M. G. A. Schols, Gertrudis I. J. M. Kempen
Summary: Most nurses find frailty screening tools helpful in daily practice, but tend to focus on evaluating patients based on specific items rather than the overall score of the tool. Additional training on the background and use of screening tools is needed when implementing frailty screening in daily practice. Further research is necessary to gain a better understanding of nurses' opinions on frailty screening.
Article
Nutrition & Dietetics
Ganna Kravchenko, Renata Korycka-Bloch, Serena S. Stephenson, Tomasz Kostka, Bartlomiej K. Soltysik
Summary: With an aging population, the concept of multimorbidity has gained interest, particularly in relation to frailty. This study aimed to assess the association between the VES-13 score, a widely used measure of frailty, and common diseases in hospitalized adults aged 60 and above. The study found that certain conditions such as diabetes, coronary artery disease, and depression were associated with higher frailty scores, while lipid disorders and gastrointestinal diseases were associated with lower frailty risk.
Review
Oncology
Kemin Li, Rutie Yin, Zhengyu Li
Summary: Frailty is associated with the poor long-term survival of patients with ovarian cancer, and high frailty may be an independent risk factor for poor survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tyler R. Chesney, Barbara Haas, Natalie G. Coburn, Alyson L. Mahar, Victoria Zuk, Haoyu Zhao, Amy T. Hsu, Julie Hallet
Summary: This study found that older adults require long-term homecare after cancer surgery, with peak usage in the first 6 months postoperatively and then stabilizing. Patients without preoperative homecare may become long-term users postoperatively, shifting towards personal support services over time.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Juan Sanchis, Clara Bonanad, Sergio Garcia-Blas, Vicent Ruiz, Agustin Fernandez-Cisnal, Clara Sastre, Arancha Ruescas, Ernesto Valero, Jessika Gonzalez, Anna Mollar, Gema Minana, Julio Nunez
Summary: Frailty and cognitive function are important predictors of poor prognosis in older adults after acute coronary syndrome, with cognitive impairment providing additional prognostic value. Geriatric assessment that includes both frailty and cognitive function could help identify high-risk individuals, especially those with moderate to severe cognitive impairment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Barbara Carpita, Laura Betti, Lionella Palego, Natalia Bartolommei, Lucia Chico, Livia Pasquali, Gabriele Siciliano, Fabio Monzani, Riccardo Franchi, Sara Rogani, Federico Mucci, Camilla Elefante, Lorenzo Lattanzi, Donatella Marazziti, Gino Giannaccini, Liliana Dell'Osso
Summary: The study found that specific alterations of redox systems are detectable among elderly patients with depression.
Article
Geriatrics & Gerontology
Alessandro Morandi, Antonella Zambon, Simona G. Di Santo, Andrea Mazzone, Antonio Cherubini, Enrico Mossello, Mario Bo, Alessandra Marengoni, Giuseppe Bellelli
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Article
Endocrinology & Metabolism
Giorgio Grani, Maria Chiara Zatelli, Marco Alfo, Teresa Montesano, Massimo Torlontano, Silvia Morelli, Maurilio Deandrea, Alessandro Antonelli, Cecilia Francese, Graziano Ceresini, Fabio Orlandi, Carolina Adele Maniglia, Rocco Bruno, Salvatore Monti, Maria Giulia Santaguida, Andrea Repaci, Giovanni Tallini, Laura Fugazzola, Fabio Monzani, Raffaele Giubbini, Ruth Rossetto, Caterina Mian, Anna Crescenzi, Dario Tumino, Loredana Pagano, Luciano Pezzullo, Celestino Pio Lombardi, Emanuela Arvat, Luisa Petrone, Maria Grazia Castagna, Giovanna Spiazzi, Domenico Salvatore, Domenico Meringolo, Erica Solaroli, Fabio Monari, Flavia Magri, Vincenzo Triggiani, Roberto Castello, Cesare Piazza, Roberta Rossi, Umberto Ferraro Petrillo, Sebastiano Filetti, Cosimo Durante
Summary: The study evaluated the real-world performance of the 2015 ATA risk stratification system in predicting the response to treatment for differentiated thyroid cancer patients. Results showed that the baseline ATA risk class was a significant predictor of structural persistent disease, while the individual treatment center did not significantly influence the prediction of the 1-year disease status. The ATA risk stratification system was found to be a reliable predictor of short-term outcomes in patients with DTC in clinical settings with center heterogeneity.
Article
Endocrinology & Metabolism
Alberto Coppelli, Rosa Giannarelli, Michele Aragona, Giuseppe Penno, Marco Falcone, Giusy Tiseo, Lorenzo Ghiadoni, Greta Barbieri, Fabio Monzani, Agostino Virdis, Francesco Menichetti, Stefano Del Prato
Article
Oncology
Giuseppe Pasqualetti, Marta Schirripa, Emmanuelle Dochy, Matteo Fassan, Pina Ziranu, Marco Puzzoni, Mario Scartozzi, Giulia Alberti, Sara Lonardi, Vittorina Zagonel, Fabio Monzani, Fotios Loupakis
EUROPEAN JOURNAL OF CANCER
(2020)
Review
Medicine, General & Internal
Domenico Fusco, Alessandro Ferrini, Giuseppe Pasqualetti, Chiara Giannotti, Matteo Cesari, Alice Laudisio, Alberto Ballestrero, Stefano Scabini, Patrizio R. Odetti, Giuseppe F. Colloca, Fabio Monzani, Alessio Nencioni, Raffaele Antonelli Incalzi, Fiammetta Monacelli
Summary: Optimizing the approach to older adults with cancer is a priority due to the increasing frequency of new cancer diagnoses in this population. The comprehensive geriatric assessment (CGA) is crucial for defining prognosis, exploring the complexity of frail older individuals, and designing personalized interventions. The adoption of a standardized CGA model by oncology centers can lead to improved therapeutic choices and clinical outcomes by facilitating comparisons, promoting multidimensional patient assessments, and integrating geriatricians into oncology care teams.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Geriatrics & Gerontology
Giuseppe Linsalata, Chukwuma Okoye, Rachele Antognoli, Daniela Guarino, Virginia Ravenna, Eugenio Orsitto, Valeria Calsolaro, Fabio Monzani
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2020)
Review
Chemistry, Medicinal
Valeria Calsolaro, Grazia Daniela Femminella, Sara Rogani, Salvatore Esposito, Riccardo Franchi, Chukwuma Okoye, Giuseppe Rengo, Fabio Monzani
Summary: Dementia, particularly Alzheimer's disease, is a growing global concern affecting millions of individuals. Treatment for behavioral and psychological symptoms should be carefully considered, weighing the advantages and limitations of antipsychotic drugs.
Article
Geriatrics & Gerontology
Chukwuma Okoye, Valeria Calsolaro, Filippo Niccolai, Alessia Maria Calabrese, Riccardo Franchi, Sara Rogani, Giulia Coppini, Virginia Morelli, Nadia Caraccio, Fabio Monzani
Summary: The aim of this single-center, open-label, randomized controlled study was to evaluate the effectiveness of cholecalciferol and calcifediol in treating hypovitaminosis D in older adults. The study found that supplementation with calcifediol resulted in significantly higher levels of 25OH-vitamin D3 compared to cholecalciferol.
Article
Geriatrics & Gerontology
Chukwuma Okoye, Sara Rogani, Riccardo Franchi, Igino Maria Pompilii, Alessia Maria Calabrese, Tessa Mazzarone, Elena Bianchi, Bianca Lemmi, Valeria Calsolaro, Fabio Monzani
Summary: Early corticosteroid therapy (ECT) does not show benefits in attenuating disease progression or reducing the escalation of care in older patients hospitalized for COVID-19 pneumonia. These findings are crucial in the current pandemic.
Review
Oncology
Sara Zuccarino, Fiammetta Monacelli, Rachele Antognoli, Alessio Nencioni, Fabio Monzani, Francesca Ferre, Chiara Seghieri, Raffaele Antonelli Incalzi
Summary: The Comprehensive Geriatric Assessment (CGA) shows potential cost-saving effects in geriatric oncology settings and has measurable benefits in reducing in-hospital length of stay and treatment toxicity. However, more research and comprehensive economic evaluations are needed to confirm these findings and further establish the value of CGA in managing older cancer patients.
Article
Medicine, General & Internal
Chukwuma Okoye, Valeria Calsolaro, Alessia Maria Calabrese, Sonia Zotti, Massimiliano Fedecostante, Stefano Volpato, Stefano Fumagalli, Antonio Cherubini, Raffaele Antonelli Incalzi, Fabio Monzani
Summary: Hospitalization for acute SARS-CoV-2 infection significantly increases the risk of post-discharge mortality and loss of functional independence among older patients. Cardiovascular diseases and respiratory failure are the most common causes of death. Pre-morbid activities of daily living (ADL) and frailty level are important factors associated with mortality and loss of independence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Chukwuma Okoye, Riccardo Franchi, Alessia Maria Calabrese, Virginia Morelli, Umberto Peta, Tessa Mazzarone, Igino Maria Pompilii, Giulia Coppini, Sara Rogani, Valeria Calsolaro, Fabio Monzani
Summary: The incidence of Long COVID syndrome is increasing, especially in the geriatric population. There is limited data on the relationship between long COVID and the risk of re-hospitalization in the oldest old survivors. A study found that 24 out of 100 patients discharged after COVID-19 hospitalization required re-hospitalization within 12 months, with the most frequent causes being acute heart failure, pneumonia, and bone fracture.
Article
Geriatrics & Gerontology
Valeria Calsolaro, Chukwuma Okoye, Sara Rogani, Alessia Maria Calabrese, Umberto Dell'Agnello, Rachele Antognoli, Daniela Guarino, Fabio Monzani
Summary: There is variability in chronic kidney disease staging with different eGFR formulas, potentially leading to inappropriate dosing of DOACs. The CKD-EPIComb formula is the best predictor for bleeding events according to the study.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Virginia Boccardi, Silvia Carino, Elisa Marinelli, Maria Lapenna, Giulia Caironi, Anna Rita Bianco, Roberta Cecchetti, Carmelinda Ruggiero, Patrizia Mecocci
Summary: This study found that serum UA levels were lower in elderly AD patients compared to healthy controls, with a significant difference. After adjusting for age, gender, BMI, and creatinine levels, UA levels were independently associated with AD diagnosis.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)