Article
Biochemistry & Molecular Biology
Su Woong Jung, Jung-Woo Seo, Seon Hwa Park, Yang Gyun Kim, Ju-Young Moon, Sangdun Choi, Sang-Ho Lee
Summary: TIP1 demonstrated significant protective effects in a mouse model of renal IRI, reducing plasma creatinine levels, alleviating tubular injury, inhibiting inflammatory cytokine expression, decreasing apoptosis and oxidative stress levels, and reducing cell infiltration, suggesting potential benefits in attenuating kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mulin Liu, Hexin Wen, Lugen Zuo, Xue Song, Zhijun Geng, Sitang Ge, Yuanyuan Ge, Rong Wu, Shiyuan Chen, Chaowen Yu, Yong Gao
Summary: This study investigated the effects of Bryo-1 on intestinal ischemia/reperfusion (I/R) injury and its mechanism. The results showed that Bryo-1 improved the intestinal barrier dysfunction caused by I/R, reduced oxidative stress damages and inflammation, and activated Nrf2/HO-1 signaling. These findings suggest that Bryo-1 protects intestines against I/R-induced injury through intestinal barrier protection and inhibition of inflammation and oxidative stress partly via Nrf2/HO-1 signaling.
Article
Biochemistry & Molecular Biology
Gustavo Sampaio de Holanda, Samuel dos Santos Valenca, Amabile Maran Carra, Renata Cristina Lopes Lichtenberger, Bianca de Castilho, Olavo Borges Franco, Joao Alfredo de Moraes, Alberto Schanaider
Summary: Acute mesenteric ischemia and reperfusion injury is a complex and lethal mechanism involving disruption of cellular microcirculation and mitochondrial damage. Fluorescent molecular probes have been shown to be highly efficient in monitoring the concentrations and locations of ROS and RNS.
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Immunology
Jiaxin Zhang, Xiaobin Zao, Jiaying Zhang, Ziwei Guo, Qian Jin, Guang Chen, Da 'nan Gan, Hongbo Du, Yong 'an Ye
Summary: Cirrhosis is a chronic liver disease characterized by fibrosis, pseudolobules, and regenerated nodules. Once hepatic decompensation occurs, reversing the impaired liver function becomes almost impossible. The development of cirrhosis is related to the intestinal microbiota and toll-like receptors pathways, which play a role in regulating cell proliferation, apoptosis, hep-atomitogen epiregulin expression, and liver inflammation. This paper reviews the changes in intestinal microbiota and toll-like receptors during cirrhosis progression and discusses potential therapeutic targets for reversing early-stage cirrhosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Surgery
Gustavo Sampaio de Holanda, Samuel dos Santos Valenca, Amabile Maran Carra, Renata Cristina Lopes Lichtenberger, Olavo Borges Franco, Beatriz Elias Ribeiro, Siane Lopes Bittencourt Rosas, Patricia Teixeira Santana, Morgana Teixeira Lima Castelo-Branco, Heitor Siffert Pereira de Souza, Alberto Schanaider
Summary: The study demonstrated that albumin and sulforaphane administered systemically can attenuate intestinal ischemia-reperfusion injury by reducing oxidative stress, thereby reducing damage and protecting gastrointestinal cells.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hyun Seok Hwang, Aida Rahimi Kahmini, Julia Prascak, Alexis Cejas-Carbonell, Isela C. Valera, Samantha Champion, Mikayla Corrigan, Florence Mumbi, Michelle S. Parvatiyar
Summary: This study investigated the role of sarcospan (SSPN) in the cardiac response to acute ischemia-reperfusion (IR) injury. The findings suggested that SSPN deficiency in mice leads to increased infarct size and arrhythmia susceptibility post-IR injury. Additionally, SSPN depletion resulted in decreased Ca2+ handling capacity and increased oxidative stress pathways in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Guangyao Li, Shuang Wang, Zhe Fan
Summary: Intestinal ischemia-reperfusion (II/R) injury not only affects the intestine itself, but can also lead to damage of distant tissues and organs. Oxidative stress plays a crucial role in the pathogenesis of II/R injury, and various signaling pathways have different effects on II/R injury.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Medicine, Research & Experimental
Fang-Ling Zhang, Xiao-Wei Chen, Yi-Fan Wang, Zhen Hu, Wen-Juan Zhang, Bo-Wei Zhou, Peng-Fei Ci, Ke-Xuan Liu
Summary: This study investigated the relationship between Lactobacillus-derived tryptophan metabolites and intestinal ischemia/reperfusion (I/R) injury. The results showed that the presence of indole-3-lactic acid (ILA) in preoperative feces was associated with better postoperative intestinal function, and ILA administration improved epithelial cell damage and alleviated oxidative stress. Mechanistically, ILA regulated the expression of YAP and Nrf2. These findings suggest that ILA is a potential therapeutic metabolite for treating intestinal I/R injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Jingjuan Hu, Fan Deng, Bingcheng Zhao, Zebin Lin, Qishun Sun, Xiao Yang, Mei Wu, Shida Qiu, Yu Chen, Zhengzheng Yan, Sidan Luo, Jin Zhao, Weifeng Liu, Cai Li, Ke Xuan Liu
Summary: This study investigated the relationship between the gut microbiome and intestinal ischemia/reperfusion (I/R) injury. It found that Lactobacillus murinus can alleviate intestinal I/R injury in mice through macrophages, and this effect may be achieved by promoting the release of IL-10 from macrophages through TLR2. This study revealed a novel mechanism of intestinal I/R injury and provided a new therapeutic strategy for clinical practice.
Article
Biochemistry & Molecular Biology
Hyeonbin Shin, Seungwon Jeong, Yeongjong Lee, Chanhee Jeon, Gayoung Kwon, Sooyeon Kim, Dongwon Lee
Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Marwa M. M. Refaie, Maram El-Hussieny, Sayed Shehata
Summary: This study aimed to evaluate the role of phosphodiesterase 3 A inhibitor (PDEI) cilostazol (CLZ) in treating ovarian ischemia reperfusion induced damage (OIR) for the first time. The results showed that CLZ can ameliorate OIR-induced damage by inhibiting PDE, possessing antioxidant, anti-inflammatory, and anti-apoptotic properties, and modulating TLR4/NF-κB/TNF-α and cAMP/SIRT1 signaling pathways.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Gastroenterology & Hepatology
Yasuaki Nagami, Masaki Ominami, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
Review
Gastroenterology & Hepatology
Koji Otani, Toshio Watanabe, Sunao Shimada, Shuhei Hosomi, Yasuaki Nagami, Fumio Tanaka, Noriko Kamata, Koichi Taira, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Yasuhiro Fujiwara
Article
Gastroenterology & Hepatology
Shuhei Hosomi, Kenji Watanabe, Yu Nishida, Hirokazu Yamagami, Tomomi Yukawa, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Hisashi Nagahara, Kiyoshi Maeda, Yasuhiro Fujiwara
INFLAMMATORY BOWEL DISEASES
(2018)
Article
Medicine, General & Internal
Tadashi Ochiai, Masaki Ominami, Yasuaki Nagami, Shusei Fukunaga, Takahiro Toyokawa, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Masaichi Ohira, Masahiko Ohsawa, Yasuhiro Fujiwara
Article
Medicine, General & Internal
Mitsuhiro Kono, Yasuaki Nagami, Masaki Ominami, Taishi Sakai, Takeshi Fukuda, Shusei Fukunaga, Fumio Tanaka, Satoshi Sugimori, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Kazunari Tominaga, Toshio Watanabe, Yasuhiro Fujiwara, Tetsuo Arakawa
Article
Nutrition & Dietetics
Shiro Nakamura, Toshio Watanabe, Sunao Shimada, Yuji Nadatani, Koji Otani, Tetsuya Tanigawa, Takako Miyazaki, Masaki Iimuro, Yasuhiro Fujiwara
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2018)
Meeting Abstract
Clinical Neurology
M. Kimura, H. Wada, R. Shirahama, Y. Suzuki, Y. Suzuki, K. Maruyama, A. Ikeda, T. Tanigawa
Article
Gastroenterology & Hepatology
Moe H. Kyaw, Koji Otani, Jessica Y. L. Ching, Akira Higashimori, Ka Man Kee, Toshio Watanabe, Yee Kit Tse, Vivian Lee, Tetsuya Tanigawa, Pui Kuan Cheong, Bing Y. Suen, Yasuhiro Fujiwara, Kelvin Lam, Tetsuo Arakawa, Francis K. L. Chan
Article
Multidisciplinary Sciences
Sunao Shimada, Tetsuya Tanigawa, Toshio Watanabe, Akinobu Nakata, Naoki Sugimura, Shigehiro Itani, Akira Higashimori, Yuji Nadatani, Koji Otani, Koichi Taira, Shuhei Hosomi, Yasuaki Nagami, Fumio Tanaka, Noriko Kamata, Hirokazu Yamagami, Masatsugu Shiba, Yasuhiro Fujiwara
Article
Multidisciplinary Sciences
Tetsuya Tanigawa, Toshio Watanabe, Akira Higashimori, Sunao Shimada, Hiroyuki Kitamura, Takuya Kuzumoto, Yuji Nadatani, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Masatsugu Shiba, Wataru Suda, Masahira Hattori, Yasuhiro Fujiwara
Summary: This study revealed that rebamipide exerts a protective effect against NSAID-induced small intestinal damage by modulating the small intestinal microbiota, and it also ameliorates the exacerbation of the damage by proton pump inhibitors.
Article
Multidisciplinary Sciences
Takuya Kuzumoto, Tetsuya Tanigawa, Akira Higashimori, Hiroyuki Kitamura, Yuji Nadatani, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara
Summary: Resolvin D1, produced by 15-lipoxygenase, protects against NSAID-induced small intestinal damage by reducing the expression of inflammatory cytokines. Inhibition of 15-lipoxygenase activity exacerbates intestinal damage, while exogenous treatment with Resolvin D1 counteracts this effect. The expression of 15-lipoxygenase in epithelial and inflammatory cells plays a crucial role in mucoprotection against NSAID-induced small intestinal damage.
Article
Gastroenterology & Hepatology
Shinji Hirano, Akira Higashimori, Yasuaki Nagami, Yuji Nadatani, Tetsuya Tanigawa, Masaki Ominami, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara
Summary: This study found that the NLRP3 inflammasome promotes esophageal stricture formation following ulcer healing, and pirfenidone (PFD) has the potential to prevent stricture formation by inhibiting the NLRP3/IL-1 beta/TGF-beta 1 axis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Shusei Fukunaga, Yasuaki Nagami, Taishi Sakai, Masaki Ominami, Satoshi Sugimori, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
GASTROINTESTINAL ENDOSCOPY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Yasuaki Nagami, Masaki Ominami, Shusei Fukunaga, Taishi Sakai, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
GASTROINTESTINAL ENDOSCOPY
(2018)