Article
Oncology
Hanquan Wu, Dengwen Dong, Jiwei Wang, Shiwen Yin, Yuanxiang Gong, Chao Yang, Yihan Bai, Junyi Wang, Yanhong Du
Summary: The study demonstrated that long noncoding RNA nuclear paraspeckle assembly transcript 1 is up-regulated in colorectal cancer tissues and cells, promoting proliferation and invasion of colorectal cancer by targeting miR-448 to promote the expression of ZEB1, which may play a significant role in the tumorigenesis of colorectal cancer.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Biochemistry & Molecular Biology
Zhao-Hui Chen, Yi-Bo Chen, Hao-Ran Yue, Xue-Jie Zhou, Hai-Yan Ma, Xin Wang, Xu-Chen Cao, Yue Yu
Summary: This study identified PAX5 as the upstream regulator of miR-142-5p/3p and demonstrated that PAX5 functions as a tumor suppressor by positively regulating miR-142-5p/3p. The expression of PAX5 is regulated by DNMT1 and ZEB1-mediated methylation of its promoter region. Moreover, miR-142-5p/3p regulates the expression of DNMT1 and ZEB1 by binding to their 3'UTR region, respectively. In conclusion, PAX5-miR-142-DNMT1/ZEB1 forms a negative feedback loop to regulate the progression of breast cancer.
MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Qing-Xiang Meng, Ke-Nie Wang, Jun-Hui Li, Hui Zhang, Zhao-Hui Chen, Xue-Jie Zhou, Xu-Chen Cao, Ping Wang, Yue Yu
Summary: The study found that ZNF384 is significantly overexpressed in breast cancer and promotes breast cancer metastasis by regulating ZEB1 expression and inducing an epithelial and mesenchymal-like phenotype. Additionally, ZNF384 may be a target of miR-485-5p, and ZEB1 can up-regulate ZNF384 expression by repressing miR-485-5p expression. These findings provide evidence for the prognostic and therapeutic potential of ZNF384 in breast cancer patients.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sergey E. Parfenyev, Sergey V. Shabelnikov, Elena N. Tolkunova, Nickolai A. Barlev, Alexey G. Mittenberg
Summary: P53 plays a critical role in protecting the genome and preventing tumor formation, including metastases. The interaction between p53 and the transcription factor Zeb1 is important in carcinogenesis, particularly in the process of epithelial to mesenchymal transition (EMT). Additionally, the composition of Zeb1 interactome is affected by the presence of cancer stem cells and the level of Oct4/Sox2 expression, indicating that stemness influences the specificity of Zeb1 interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lenka Kalinkova, Nataliia Nikolaieva, Bozena Smolkova, Sona Ciernikova, Karol Kajo, Vladimir Bella, Viera Horvathova Kajabova, Helena Kosnacova, Gabriel Minarik, Ivana Fridrichova
Summary: This study investigates the prognostic features for invasion and metastasis in breast cancer. It identifies miR-205-5p and ZEB1 gene as potential markers for metastatic potential in ductal breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhu, Fengchun Wang, Wenhui Fan, Zhi Jin, Chao Teng, Jianxin Zhang
Summary: NEAT1 is upregulated in breast tumors and cell lines, and silencing NEAT1 sensitizes breast cancer cells to Taxol. miR-23a-3p is downregulated in breast cancer and acts as a tumor suppressor. In Taxol-resistant MDA-MB-231 breast cancer cells, NEAT1 is significantly increased and miR-23a-3p is downregulated, with FOXA1 identified as a target of miR-23a-3p.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Genetics & Heredity
Xinyu Wei, Shuang Tao, Huilan Mao, Haitao Zhu, Lingyu Mao, Wenhao Pei, Xiuru Shi, Yingxiang Shi, Shiwen Zhang, Yulun Wu, Ke Wei, Jing Wang, Siyan Pang, Wenrui Wang, Changjie Chen, Qingling Yang
Summary: This study found that lncRNA NEAT1 is highly expressed in BC cells and exosomes. NEAT1 promotes migration and paclitaxel resistance in BC cells, while downregulation of NEAT1 reduces drug resistance. In addition, downregulation of NEAT1 decreases migration and proliferation of BC cells by inhibiting CXCL12 expression and reducing miR-133b adsorption. This study reveals that exosomal lncRNA NEAT1 derived from SKBR3/PR cells in the tumor microenvironment can induce paclitaxel resistance, cell migration, and growth, and may serve as a new target for clinical treatment of BC.
Article
Multidisciplinary Sciences
Guojun Liu, Xuqun Huang
Summary: In breast cancer, circRNA_0000518 promotes cancer progression by acting as a molecular sponge for miR-1258, inducing ZEB1 expression.
Article
Medicine, General & Internal
Yizhou Zhou, Li Sun, Yangmei Zhang, Kai Chen
Summary: The study reveals that miR-448 regulates the expression of ZEB1, inhibiting cell proliferation and invasion, promoting apoptosis, and increasing sensitivity to chemotherapy drugs such as paclitaxel and 5-fluorouracil.
Article
Cell Biology
Mi Kyung Park, Li Zhang, Kyung-Won Min, Jung-Hyun Cho, Chih-Chen Yeh, Hyesu Moon, Daniel Hormaechea-Agulla, Hyejin Mun, Seungbeom Ko, Ji Won Lee, Sonali Jathar, Aubrey S. Smith, Yixin Yao, Nguyen Thu Giang, Hong Ha Vu, Victoria C. Yan, Mary C. Bridges, Antonis Kourtidis, Florian Muller, Jeong Ho Chang, Su Jung Song, Shinichi Nakagawa, Tetsuro Hirose, Je-Hyun Yoon, Min Sup Song
Summary: This study uncovers the important role of NEAT1 in cancer, showing that it promotes efficient glycolysis by facilitating the assembly of enzyme complexes. The upregulation of NEAT1 in cancer patients is associated with tumor development, and its regulation of tumor metabolism provides new insights for cancer therapy.
Article
Biotechnology & Applied Microbiology
Lu Ren, Shaoqin Yang, Qinxue Cao, Jun Tian
Summary: The study revealed that CRNDE promotes cervical cancer progression by regulating the wnt/beta-catenin pathway through interaction with miR-4262 and ZEB1. CRNDE acts as an oncogene in cervical cancer by modulating cell proliferation, migration, invasion, and apoptosis. Targeting the CRNDE/miR-4262/ZEB1 axis may offer a potential therapeutic strategy for cervical cancer.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Xueyou Ma, Yufan Ying, Jiazhu Sun, Haiyun Xie, Jiangfeng Li, Liujia He, Weiyu Wang, Shiming Chen, Haixiang Shen, Jiahe Yi, Jindan Luo, Xiao Wang, Xiangyi Zheng, Ben Liu, Liping Xie
Summary: circKDM4C acts as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, suggesting its potential as a biomarker or therapeutic target for bladder cancer.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Yabin Li, Xirui Wang, Zhihuang Zhao, Jinxing Shang, Gang Li, Ruijian Zhang
Summary: NEAT1 plays an oncogenic role in glioma progression by promoting cell proliferation and interacting with miR-98-5p and BZW1. Inhibition of NEAT1 through the miR-98-5p/BZW1 pathway suppresses glioma cell proliferation in vivo. Targeting NEAT1/miR-98-5p/BZW1 may provide a novel therapeutic approach for glioma patients.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Florian Posch, Felix Prinz, Amar Balihodzic, Christian Mayr, Tobias Kiesslich, Christiane Klec, Katharina Jonas, Dominik A. Barth, Jakob M. Riedl, Armin Gerger, Martin Pichler
Summary: Biliary tract cancer is a rare malignancy with poor survival rates, and cisplatin-based treatments are commonly used as first-line strategies. MiR-200c-3p may play a significant role in cisplatin resistance in biliary tract cancer, independent of its interaction with ZEB1.