miR-181b-induced SMAD7 downregulation controls granulosa cell apoptosis through TGF-β signaling by interacting with the TGFBR1 promoter

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling

(2017) Ryan J. Malonis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7

(2017) Li Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity

(2017) Dominika Lukas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death

(2017) Veronica De Simone et al.   Cell Death & Disease

MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells

(2017) Jiawei Zhou et al.   Cell Death & Disease

GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary

(2017) Chen Jiang et al.   PLoS Genetics

Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice

(2017) T Feng et al.   Oncogenesis

miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling

(2017) Daijiro Hori et al.   PLoS One

Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-β signaling

(2016) Bisheng Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Smad2/3/4 Pathway Contributes to TGF-β-Induced MiRNA-181b Expression to Promote Gastric Cancer Metastasis by Targeting Timp3

(2016) Qi Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A dominant negative mutation at the ATP binding domain ofAMHR2is associated with a defective anti-Müllerian hormone signaling pathway

(2016) Lin Li et al.   MOLECULAR HUMAN REPRODUCTION

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST

(2016) L K Zhuang et al.   Cell Death & Disease

TGF-β signaling controls FSHR signaling-reduced ovarian granulosa cell apoptosis through the SMAD4/miR-143 axis

(2016) Xing Du et al.   Cell Death & Disease

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

(2016) Jingyi Yu et al.   Nature Communications

MicroRNA-196b is transcribed from an autonomous promoter and is directly regulated by Cdx2 and by posterior Hox proteins during embryogenesis

(2015) Sebastian Fantini et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inhibitory SMADs: Potential Regulators of Ovarian Function1

(2015) Qinglei Li   BIOLOGY OF REPRODUCTION

miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway

(2015) Z Zhu et al.   BRITISH JOURNAL OF CANCER

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood

(2015) Hua Zhang et al.   HUMAN REPRODUCTION UPDATE

Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization

(2015) Giovanni Coticchio et al.   HUMAN REPRODUCTION UPDATE

Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling

(2015) Xiaohua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7

(2015) Fujun Yu et al.   LABORATORY INVESTIGATION

The let-7g microRNA promotes follicular granulosa cell apoptosis by targeting transforming growth factor-β type 1 receptor

(2015) Jilong Zhou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback

(2015) Wenchao Gu et al.   PLOS BIOLOGY

MicroRNA-21 promotes osteogenic differentiation by targeting small mothers against decapentaplegic 7

(2015) HONGQIU LI et al.   Molecular Medicine Reports

MicroRNA 181b Regulates Decorin Production by Dermal Fibroblasts and May Be a Potential Therapy for Hypertrophic Scar

(2015) Peter Kwan et al.   PLoS One

MiR-181b regulates cisplatin chemosensitivity and metastasis by targeting TGFβR1/Smad signaling pathway in NSCLC

(2015) Xiaoyuan Wang et al.   Scientific Reports

Granulosa cell function and oocyte competence: Super-follicles, super-moms and super-stimulation in cattle

(2014) F.C.F. Dias et al.   ANIMAL REPRODUCTION SCIENCE

MicroRNA-26b Functions as a Proapoptotic Factor in Porcine Follicular Granulosa Cells by Targeting Sma-and Mad-Related Protein 41

(2014) Jiying Liu et al.   BIOLOGY OF REPRODUCTION

Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGF -Activating miR424-503 Gene Cluster

(2014) Y. Li et al.   CANCER RESEARCH

miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors

(2014) C. Gong et al.   CANCER RESEARCH

Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes

(2014) J. R. Egbert et al.   DEVELOPMENT

MiR-92a inhibits porcine ovarian granulosa cell apoptosis by targetingSmad7gene

(2014) Jiying Liu et al.   FEBS LETTERS

Transforming Growth Factor-β Signaling Participates in the Maintenance of the Primordial Follicle Pool in the Mouse Ovary

(2014) Zheng-Pin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β1 Induces COX-2 Expression and PGE2 Production in Human Granulosa Cells Through Smad Signaling Pathways

(2014) Lanlan Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNA-92a Inhibition Attenuates Hypoxia/Reoxygenation-Induced Myocardiocyte Apoptosis by Targeting Smad7

(2014) Busheng Zhang et al.   PLoS One

Smad7 regulates terminal maturation of chondrocytes in the growth plate

(2013) Kristine D. Estrada et al.   DEVELOPMENTAL BIOLOGY

Sma- and Mad-related Protein 7 (Smad7) Is Required for Embryonic Eye Development in the Mouse

(2013) Rui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMAD7 antagonizes key TGFβ superfamily signaling in mouse granulosa cells in vitro

(2013) Yang Gao et al.   REPRODUCTION

MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation

(2013) Qiong Li et al.   Scientific Reports

miR-181b Promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients

(2012) Baocan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Smad7 is a transforming growth factor-beta–inducible mediator of apoptosis in granulosa cells

(2012) Marisol Quezada et al.   FERTILITY AND STERILITY

Follicular Growth and Atresia in Mammalian Ovaries: Regulation by Survival and Death of Granulosa Cells

(2012) Fuko MATSUDA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

The miR-106b-25 cluster targets Smad7, activates TGF-β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

(2012) A L Smith et al.   ONCOGENE

miR-26b Promotes Granulosa Cell Apoptosis by Targeting ATM during Follicular Atresia in Porcine Ovary

(2012) Fei Lin et al.   PLoS One

Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) Ingo Kleiter et al.   BRAIN

Localization of phosphorylated SMAD proteins in granulosa cells, oocytes and oviduct of female mice

(2010) X. Tian et al.   GENE EXPRESSION PATTERNS

MicroRNA-224 Is Involved in Transforming Growth Factor-β-Mediated Mouse Granulosa Cell Proliferation and Granulosa Cell Function by Targeting Smad4

(2010) Guidong Yao et al.   MOLECULAR ENDOCRINOLOGY

TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

(2009) B Wang et al.   ONCOGENE

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

Smad7 Is Required for the Development and Function of the Heart

(2008) Qian Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

(2008) Marcin Kowanetz et al.   JOURNAL OF CELL BIOLOGY

Transforming growth factor-β: its role in ovarian follicle development

(2008) Davina Rosairo et al.   REPRODUCTION