期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 233, 期 9, 页码 6822-6831出版社
WILEY
DOI: 10.1002/jcp.26432
关键词
ceRNA; glioma; GLS; glutamine metabolism; HOTAIR; MiR-126-5p
资金
- Program Funding for Health Youth Talent Training Project of Nanjing [QRX-11027]
- Natural Science Foundation of Jiangsu Province [BK20161119]
- National Natural Sciences Foundation of China [81502168, 81602212]
- Scientific and Technologic Development Program of Nanjing City [20160525, 201503026]
- Key Project - Medical Science and Technology Development Foundation, Nanjing Department of Health [YKK16139, YKK12139]
- Science and Technology Development Foundation of Nanjing Medical University [2014NJMUZD032]
LncRNA HOX transcript antisense intergenic RNA (HOTAIR) has been shown to play prominent roles in tumorigenesis. However, its precise molecular mechanism in glioma has not been completely elucidated. In this study, we found that HOTAIR was aberrantly up-regulated in glioma tissues and was negatively correlated with miR-126-5p expression. Next, we determined that HOTAIR promote glioma progression by sponging miR-126-5p. Subsequently, glutaminase (GLS) was confirmed to be a direct target of miR-126-5p using bioinformatics software and a luciferase reporter assay. Moreover, HOTAIR could modulate GLS expression by functioning as a competing endogenous RNA (ceRNA) for miR-126-5p. Taken together, our study clarified that the HOTAIR/miR-126/GLS pathway is involved in glioma progression and may potentially serve as a target for glioma therapy.
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