Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Andrei Sorop, Diana Constantinescu, Florentina Cojocaru, Anca Dinischiotu, Dana Cucu, Simona Olimpia Dima
Summary: Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and is often detected late due to its high clinical and biological heterogeneity. Small nanoparticles with an endosomal origin are valuable biomarkers or carriers for novel treatments in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Veronica Zelli, Chiara Compagnoni, Roberta Capelli, Alessandra Corrente, Mauro Di Vito Nolfi, Francesca Zazzeroni, Edoardo Alesse, Alessandra Tessitore
Summary: Extracellular vesicles (EVs), including exosomes, play crucial roles in hepatocellular carcinoma (HCC) therapy. Exosomal miRNAs carried by EVs are involved in regulating tumor behavior, reshaping tumor microenvironment, and contributing to drug resistance mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Thorben Fruendt, Linda Krause, Elaine Hussey, Bettina Steinbach, Daniel Koehler, Johann von Felden, Kornelius Schulze, Ansgar W. Lohse, Henning Wege, Heidi Schwarzenbach
Summary: Exosomes carrying small non-coding RNA, particularly miR-16, miR-146a, miR-192, and miR-221, appear to be promising diagnostic and prognostic markers for hepatocellular carcinoma (HCC) and liver cirrhosis patients. MiR-146a showed potential as a diagnostic marker for distinguishing HCC patients from liver cirrhosis patients, while miR-192 independently correlated with overall survival in HCC patients.
Review
Gastroenterology & Hepatology
Hai-Chen Wang, Wen-Xuan Yin, Meng Jiang, Jia-Yi Han, Xing-Wang Kuai, Rui Sun, Yu-Feng Sun, Ju-Ling Ji
Summary: Exosomes, as important components of the tumor microenvironment, play a crucial role in the development and treatment of hepatocellular carcinoma (HCC) through the delivery of miRNAs. The miRNAs in exosomes can originate from various cell types and are associated with stromal cells and immune cells in the tumor microenvironment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Zuzana Krupova, Christine Leroux, Christine Pechoux, Claudia Bevilacqua, Patrice Martin
Summary: miRNAs in milk are mainly found in extracellular vesicles (EVs), which are released by cells for communication. Most previous studies focused on human and cow's milk, so this study aimed to profile miRNAs in purified EVs from healthy goats and compare them to healthy cows at early lactation. The EVs were characterized and confirmed to be free of milk protein contamination. The size distribution and concentration of EVs from both goats and cows were similar. RNA-sequencing identified a total of 295 miRNAs, providing the first-time validation of goat miRNome using cow miRNomes.
Review
Pharmacology & Pharmacy
Liangyun Li, Yihui Bi, Shaoxi Diao, Xiaofeng Li, Tong Yuan, Tao Xu, Cheng Huang, Jun Li
Summary: This review article highlights the role of exosomal lncRNAs in the development of HCC, showing their crucial involvement in the growth and progression of HCC and their potential as therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Immunology
Sihang Yu, Lei Zhou, Jiaying Fu, Long Xu, Buhan Liu, Yuanxin Zhao, Jian Wang, Xiaoyu Yan, Jing Su
Summary: There is increasing evidence showing the crucial role of the immune microenvironment, particularly the polarization state and function of macrophages, in the development of hepatocellular carcinoma. Tumor-derived exosomes in hepatocellular carcinoma act as information carriers and regulate the physiological state of cells in the microenvironment, thus controlling cancer progression. This review focuses on the role of exosome content in disease outcomes at different stages of hepatitis B virus/hepatitis C virus-induced hepatocellular carcinoma, and explores the mechanism by which macrophages contribute to hepatocellular carcinoma formation and the regulation of macrophage functions by the heterogeneity of exosome loading. The application prospects of exosome-based targeted drug delivery in immunotherapy research on hepatocellular carcinoma are also summarized.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Tian-Run Lv, Hai-Jie Hu, Parbatraj Regmi, Fei Liu, Fu-Yu Li
Summary: Sarcomatoid hepatocellular carcinoma (SHCC) is a rare subtype of primary liver malignancies. Compared to conventional hepatocellular carcinoma (HCC), SHCC has worse prognosis and exhibits more aggressive behavior.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhijun Liu, Yuyu You, Qiyi Chen, Guobang Li, Wenfeng Pan, Qing Yang, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Fuming Li, Bo Li
Summary: Hepatocellular carcinoma (HCC) is characterized by metabolic and immune remodeling in the tumor microenvironment. Liver-specific deletion of fructose-1, 6-bisphosphatase 1 (FBP1) promotes liver tumorigenesis, partly due to the suppression of natural killer (NK) cells. Mechanistically, FBP1 attenuation in hepatocytes inhibits PKLR expression and reduces the activity of NK cells by transferring PKLR-attenuated extracellular vesicles (EVs) from hepatocytes.
Article
Biochemistry & Molecular Biology
Lin Zhu, Yan Lou, Qiyu Xiao, Ling Wang, Guodong Chen, Wenjun Yang, Tengjiao Wang
Summary: A risk prognosis model based on mRNA expression levels in exosomes from blood samples of liver cancer patients was established, which showed good accuracy and reliability in the diagnosis and prognosis of liver cancer. This model provides new targets for liver cancer detection and management.
BIOCHEMICAL GENETICS
(2023)
Article
Cell Biology
Zeng-Hong Wu, Cheng Li, You-Jing Zhang, Rong Lin
Summary: This study identified atypical signature exosomes for hepatocellular carcinoma (HCC) based on analyses of exosome and online databases, providing potential biomarkers for HCC treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
GuoYun Wang, GaiXiang Luo, MeiJing Zhao, HuiLai Miao
Summary: This article discusses the research progress on exosomes in the development of hepatocellular carcinoma, tumor microenvironment, treatment resistance, and immunosuppression. Understanding the pathogenesis and identifying early diagnostic markers are crucial for diagnosing and treating HCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Shuang Li, Limin Chen
Summary: Exosomes are extracellular vesicles that play important roles in cell-to-cell communication and can be stably present in various body fluids. They have a unique double-layer saclike structure and reflect the characteristics of their host cells. Exosomes derived from hepatocellular carcinoma cells show heterogeneity in their cargo. Additionally, exosomes are capable of efficiently delivering cargoes to target cells, which significantly impact HCC progression, including tumor occurrence, development, metastasis, immune regulation, and drug resistance. Previous studies have demonstrated wide applications of exosomes in the diagnosis and treatment of HCC. This review discusses recent findings on the significant roles of exosomes in HCC, focusing on their effects and underlying mechanisms in regulating HCC progression and their potential clinical value as biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Dongdong Xue, Ya Zheng, Junye Wen, Jingzhao Han, Hongfang Tuo, Yifan Liu, Yanhui Peng
Summary: Chemokines play a vital role in hepatocellular carcinoma (HCC), participating in biological processes such as inflammation, tumor immune response, proliferation, invasion, and metastasis by modulating various signaling pathways. Chemokines and their receptors directly or indirectly influence the tumor microenvironment, shaping the biological behavior of the tumor.
Review
Cell Biology
Jin-Yu Sun, Tailang Yin, Xiao-Yu Zhang, Xiao-Jie Lu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Genetics & Heredity
An-Liang Xia, Yong Xu, Xiao-Jie Lu
JOURNAL OF MEDICAL GENETICS
(2019)
Review
Immunology
Anliang Xia, Yan Zhang, Jiang Xu, Tailang Yin, Xiao-Jie Lu
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Cell Biology
Jin-Yu Sun, Tai-Lang Yin, Jianhua Zhou, Jiang Xu, Xiao-Jie Lu
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Dong Ji, Guo-Feng Chen, Jin-Cheng Wang, Si-Han Ji, Xue-Wen Wu, Xiao-Jie Lu, Jin-Lian Chen, Jing-Tao Li
Editorial Material
Oncology
Xiao-Jie Lu
Editorial Material
Oncology
Jin-Yu Sun, Xiao-Jie Lu
Review
Oncology
Jin-Yu Sun, Dengke Zhang, Songquan Wu, Min Xu, Xiao Zhou, Xiao-Jie Lu, Jiansong Ji
BIOMARKER RESEARCH
(2020)
Article
Oncology
Xiao-Jie Lu, Xiao-Jun Yang, Jing-Yu Sun, Xin Zhang, Zhao-Xin Yuan, Xiu-Hui Li
BIOMARKER RESEARCH
(2020)
Editorial Material
Genetics & Heredity
Xiaoling Weng, Xiao-Jie Lu
Article
Cell Biology
Jianfei Tu, Weiqian Chen, Liyun Zheng, Shiji Fang, Dengke Zhang, Chunli Kong, Yang Yang, Rongfang Qiu, Zhongwei Zhao, Chenying Lu, Xiaojie Lu, Jiansong Ji
Summary: The study revealed that circ_0021205 was up-regulated in CCA and positively correlated with tumor size and TNM stage. It promoted the proliferation, migration, and invasion of CCA cells by sponging miR-204-5p and regulating the expression of RAB22A, serving as a potential diagnostic biomarker or therapeutic target for CCA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Jin-Yu Sun, Rui Wu, Jiang Xu, Hui-Ying Xue, Xiao-Jie Lu, Jiansong Ji
Summary: The immune system plays a crucial role in recognizing and attacking non-self antigens, leading to immunity against infection. However, it also causes immune rejection during organ transplantation. Understanding the mechanisms of maternal-fetal immune tolerance can potentially improve transplantation outcomes by balancing immune tolerance and infection defense. Studies exploring the interconnection between immune tolerance in pregnancy and organ transplantation highlight the impact of pregnancy alloimmunization on transplant success.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Xiaoling Weng, Xiao-Jie Lu
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Xiaochen Wang, Jianchu Wang, Haiyuan Shen, Zongjiang Luo, Xiaojie Lu
Summary: This study found that TPX2 regulates the antitumor effect of CD8 + T cells in hepatocellular carcinoma (HCC) by modulating CXCR5. Overexpression of TPX2 enhances the anticancer function of CD8 + T cells and shows synergistic effects with anti-PD-1 therapy.
CELL DEATH & DISEASE
(2022)
Review
Oncology
David Prince, Ken Liu, Weiqi Xu, Minjiang Chen, Jin-Yu Sun, Xiao-Jie Lu, Jiansong Ji
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2020)