Article
Biochemistry & Molecular Biology
Xianhui Ruan, Yue Huang, Lin Geng, Mengran Tian, Yu Liu, Mei Tao, Xiangqian Zheng, Peng Li, Min Zhao
Summary: Single-cell transcriptome sequencing provides higher resolution for cellular differences in papillary thyroid carcinoma. Through integrative analysis of two datasets, we identified 31 consistently differentially expressed genes across multiple cell types, which are related to adaptive immune response and autoimmune thyroid diseases. Experimental validation suggests that KRT7 may be a potential biomarker for PTC epithelial cells.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Oncology
Mohammad Roshani, Ghazaleh Baniebrahimi, Mahboubeh Mousavi, Noushid Zare, Reza Sadeghi, Reza Salarinia, Amirhossein Sheida, Danial Molavizadeh, Sara Sadeghi, Farzaneh Moammer, Mohammad Reza Zolfaghari, Hamed Mirzaei
Summary: Exosomal lncRNAs play a crucial role in the biology of gastrointestinal cancer and can be utilized as biomarkers for diagnosis, prognosis, and potential treatment targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Chang Liu, Yu Pan, Qinyu Li, Yifan Zhang
Summary: The study identified a potential association between Hashimoto's thyroiditis (HT) and papillary thyroid cancer (PTC), showing that the expression of LTF and CCL21 differs significantly in the two diseases. This suggests underlying connections between HT and PTC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Xubin Dong, Cong Jin, Danxiang Chen, Yizuo Chen, Zhi-qiang Ye, Xiaohua Zhang, Xiaoli Huang, Wei Zhang, Dian-na Gu
Summary: By analyzing lncRNA expression and somatic mutation profiles, significant GI-related lncRNAs in PTC were identified. A computational model based on four lncRNAs was established as a quantitative index for poor prognosis prediction. The study demonstrated the potential of lncRNAs as cancer biomarkers and provided insights into the biological mechanisms of GI in PTC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Juan Zhang, Ying Ma, Daojun Xie, Yuancheng Bao, Wenming Yang, Han Wang, Huaizhou Jiang, Hui Han, Ting Dong
Summary: This study investigated the lncRNA-mRNA regulation network in a TX WD mouse model, identifying differentially expressed lncRNAs and mRNAs associated with WD liver injury. Functional and pathway analyses revealed enrichment in key processes such as apoptosis and pathways including drug metabolism and signaling pathways. The differential lncRNAs identified may play a role in the pathogenesis and development of WD liver injury.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lei Dai, Weidong Zhang, Yinchun Wang, Kejie Yu, Qi Le, Xianjiang Wu
Summary: This study analyzed the dysregulated profile of circular RNAs (circRNAs) in papillary thyroid cancer (PTC) tissues and found that circAGTPBP1 was upregulated and correlated with tumor characteristics. The downstream targets of circAGTPBP1 were identified as miR-34a-5p and NOTCH1. Functional experiments showed that circAGTPBP1 knockdown inhibited PTC cell migration, invasion, and metastasis, and miR-34a-5p inhibitor reversed these effects. CircAGTPBP1 knockdown also inhibited tumor growth in vivo, suggesting its potential as a therapeutic target for PTC.
Article
Multidisciplinary Sciences
Changsheng Guo, Yuanqing Hua, Zuanhao Qian
Summary: This study identified differentially expressed lncRNAs and genes in Kawasaki disease (KD), as well as constructed ceRNA networks involving miRNAs and mRNAs. The study found specific lncRNAs (PSORS1C3, LINC00999, SNHG5) and genes (GATA3, SOD2, MAPK14, PPARG) that may play a key role in the pathogenesis and development of KD. Validation in a separate dataset showed that intravenous immunoglobulin treatment alleviated the deregulated RNA profiles in KD patients.
Review
Endocrinology & Metabolism
Xiaoqin Xu, Jiexian Jing
Summary: This paper provides a comprehensive review of the role of circRNAs in papillary thyroid carcinoma, including their regulatory functions, pathological mechanisms, and clinical significance, as well as discussing the challenges in this specific field.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Junwei Zhao, ShuHui Gao, Chunguang Chen, Hui Li, Shaohua Wang, Yongmin Yu, Liang Ming
Summary: Efforts to eradicate MDR-TB are hindered by drug resistance. This study identifies differentially expressed lncRNAs and mRNAs in MDR-TB patients and reveals potential biomarkers such as lncRNA n335659. GO and KEGG analyses provide insights into the biological functions and signaling pathways associated with MDR-TB.
Article
Biochemistry & Molecular Biology
Wen Xiao, Yi Lai, Haojie Yang, Huafa Que
Summary: This study aimed to evaluate the potential prognostic value of ferroptosis-related long non-coding RNAs (lncRNAs) in papillary thyroid carcinoma (PTC). A total of 10 lncRNA pairs with differential expression levels were obtained. The risk assessment model constructed using FRLs showed good predictive value for the prognosis of patients with PTC.
BIOCHEMICAL GENETICS
(2023)
Article
Oncology
Weiqian Guo, Xiaomin Zheng, Lei Hua, Xianbin Zheng, Yangyang Zhang, Bin Sun, Zhenchao Tao, Jin Gao
Summary: Differentiated expressed genes for nasopharyngeal carcinoma were identified and potential biomarkers were explored through bioinformatical analysis. The core genes screened may serve as prognostic and diagnostic biomarkers for NPC.
Article
Cell Biology
Deguang Zhang, Li Tao, Nizheng Xu, Xiaoxiao Lu, Jianle Wang, Gaofei He, Qinghu Tang, Kangmao Huang, Shuying Shen, Junjie Chu
Summary: In this study, circRNA high-throughput sequencing was used to identify alterations in circRNA expression levels in PTC tissues. circTIAM1 was found to be upregulated in PTC and associated with apoptosis, proliferation, and migration of PTC cells. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. These findings highlight the oncogenic role of circTIAM1 in PTC and suggest its potential as a therapeutic target for PTC progression.
CELL DEATH DISCOVERY
(2022)
Review
Endocrinology & Metabolism
Mirjana T. Macvanin, Zoran M. Gluvic, Bozidarka L. Zaric, Magbubah Essack, Xin Gao, Esma R. Isenovic
Summary: After the metabolic syndrome, thyroid disorders are the most common endocrine disorders with increasing prevalence. They can be distinguished by hyperthyroidism, hypothyroidism, or thyroiditis, as well as the presence of benign or malignant thyroid nodules. Current methods for detecting thyroid cancer have limitations, and with the advancement of molecular biology techniques, new biomarkers such as mRNA and non-coding RNAs have the potential to improve diagnosis and prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Wenkuan Chen, Jianchang Fu, Yingle Chen, Yudong Li, Li Ning, Dou Huang, Shumei Yan, Quan Zhang
Summary: The study revealed high expression of circKIF4A in papillary thyroid cancer, and knocking it down could suppress cancer cell growth and migration. CircKIF4A was found to promote tumor progression by regulating miR-1231 and GPX4 expression. Targeting circKIF4A may be a potential method for future treatment of papillary thyroid cancer.
Review
Cell Biology
Zijun Xie, Chenming Zhong, Shiwei Duan
Summary: miR-1269a and miR-1269b play important roles in the occurrence and development of multiple cancers. They have the potential to be diagnostic and prognostic markers for cancer. Further research can focus on elucidating more upstream and downstream genes and exploring the clinical application value of miR-1269a and miR-1269b.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
