Review
Biochemistry & Molecular Biology
Ismael Riquelme, Pablo Perez-Moreno, Barbara Mora-Lagos, Carmen Ili, Priscilla Brebi, Juan Carlos Roa
Summary: Gastric cancer is a significant cause of cancer-related deaths, particularly among younger people. Late diagnosis, metastasis, and drug resistance contribute to the high mortality rate of gastric cancer. There is a need for new biomarkers and therapeutic targets. RNA-seq technology has identified long non-coding RNAs (lncRNAs) as potential regulators of cancer cells' signaling pathways, including the PI3K/AKT/mTOR pathway, and they may serve as diagnostic or prognostic biomarkers or therapeutic targets for gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yixin Zhang, Yingjie Wu, Xiaobao Su
Summary: This study demonstrates that PLOD1 plays a role in gastric cancer progression by activating the SOX9/PI3K/Akt/mTOR signaling pathway, promoting cell growth and aerobic glycolysis.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Cell Biology
Xuemei Shen, Jia Tang, Rui Jiang, Xiaogang Wang, Zhaoxin Yang, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen
Summary: This study identified a novel circRILPL1 that acts as a sponge for miR-145 to regulate the IGF1R gene, promoting myoblast growth.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
Summary: The study revealed that high expression of E2F2 in gastric cancer is associated with poor prognosis, and it promotes cancer cell migration and invasion by inhibiting autophagy through the PI3K/Akt/mTOR pathway. E2F2 may also modulate tumor immunity.
Article
Oncology
Danfang Wang, Jianhui Li, Wenhan Li
Summary: This study investigates the role of LHPP in gastric cancer (GC) and finds that LHPP acts as a tumor suppressor gene by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. The underlying mechanism involves regulating the PI3K/AKT/mTOR pathway.
Article
Biochemistry & Molecular Biology
Shengyu Cui, Zhebo Liu, Bo Tao, Suzhen Fan, Yong Pu, Xiangping Meng, Dongqing Li, Hao Xia, Lin Xu
Summary: This study found that miR-145 can alleviate cardiac fibrosis and improve cardiac function in myocardial infarction by negatively regulating SOX9 and its downstream signaling pathways.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Cell & Tissue Engineering
Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang, Xiaocheng Wang, Maosheng Cheng, Jie Chen, Zhi Chen, Jianwen Chen, Caihua Zhang, Gan Xiong, Xiuyun Xu, Demeng Chen, Heping Li, Liang Peng
Summary: Our study demonstrates that Sox9-expressing cells promote lung tissue regeneration, with their ablation leading to severe radiation damage phenotypes. Through analysis of an online scRNA-Seq dataset, we found that the PI3K/AKT pathway is enriched in Sox9-expressing cells during lung epithelium regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Chao Wang, Zhi Yang, En Xu, Xiaofei Shen, Xingzhou Wang, Zijian Li, Heng Yu, Kai Chen, Qiongyuan Hu, Xuefeng Xia, Song Liu, Wenxian Guan
Summary: This study found that APOC2 is overexpressed in GC PM tissues and correlates with poor prognosis in GC patients. APOC2 promotes invasion, migration, and proliferation of GC cells through CD36-mediated PI3K/AKT/mTOR signaling pathway.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Review
Oncology
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Artur Slupianek, Radoslaw Sierpinski, Ireneusz Majsterek
Summary: The PI3K/Akt/mTOR pathway is crucial in cancer development and can be a potential therapeutic target for leukemia. Recent research indicates that inhibition of this pathway may lead to improved treatment outcomes for leukemia.
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Food Science & Technology
Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Soo-Hyun Jung, Bum Seok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Summary: The study demonstrates that oleanolic acid (OA) can inhibit cell viability, induce apoptosis and autophagy, thereby interfering with the proliferation and development of gastric cancer cells, reducing the phosphorylation levels of the PI3K/AKT/mTOR signaling pathway, exhibiting anti-cancer effects, and showing tumor-reducing effects in a mouse model.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Gastroenterology & Hepatology
Yu Hu, Ying Zhang, Meng Ding, Ruisi Xu
Summary: The study found that TMPO-AS1 is highly expressed in gastric cancer tissues and cells, promoting proliferation, migration, and angiogenesis of gastric cancer cells, and upregulating BRCC3 expression by acting as a competing endogenous RNA for miR-126-5p. The TMPO-AS1/miR-126-5p/BRCC3 axis contributes to gastric cancer progression by regulating the PI3K/Akt/mTOR pathway.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guang Chen, Huhu Zhang, Hongxiao Sun, Xiaoyan Ding, Guoxiang Liu, Fanghao Yang, Guilin Feng, Xiaolei Dong, Yunfan Zhu, Xiaotong Wang, Yafei Wang, Bing Li, Lina Yang
Summary: Gastric cancer (GC) is a common malignant tumor and bufalin has been proven to play an anticancer role in various cancers. However, the studies on bufalin in GC are limited. This study aimed to investigate the effect of bufalin on GC cells and identify its direct interaction protein and target. The results showed that bufalin inhibited the proliferation and migration of GC cells in vitro. BFAR was identified as a direct interaction protein of bufalin that promotes the occurrence and metastasis of GC through the PI3K/AKT/mTOR signaling pathway. Bufalin reversed the promoting effect of BFAR on GC and inhibited its development. These findings suggest that bufalin targeting BFAR could be a promising drug for the treatment of GC.
