Article
Pharmacology & Pharmacy
Babak Jahangiri, Mohammad Khalaj-Kondori, Elahe Asadollahi, Leyli Purrafee Dizaj, Majid Sadeghizadeh
Summary: This study found that exosomes derived from mesenchymal stem cells (MSC-Exos) can suppress proliferation, migration, invasion, and metastasis while inducing apoptosis of colorectal cancer (CRC) cells through the miR-100/mTOR/miR-143 axis. These findings suggest that MSC-Exo treatment and miR-100 restoration may be potential therapeutic strategies for CRC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Zuzana Krupova, Christine Leroux, Christine Pechoux, Claudia Bevilacqua, Patrice Martin
Summary: miRNAs in milk are mainly found in extracellular vesicles (EVs), which are released by cells for communication. Most previous studies focused on human and cow's milk, so this study aimed to profile miRNAs in purified EVs from healthy goats and compare them to healthy cows at early lactation. The EVs were characterized and confirmed to be free of milk protein contamination. The size distribution and concentration of EVs from both goats and cows were similar. RNA-sequencing identified a total of 295 miRNAs, providing the first-time validation of goat miRNome using cow miRNomes.
Article
Biochemistry & Molecular Biology
Valentina Maggisano, Francesca Capriglione, Antonella Verrienti, Marilena Celano, Agnese Gagliardi, Stefania Bulotta, Marialuisa Sponziello, Catia Mio, Valeria Pecce, Cosimo Durante, Giuseppe Damante, Diego Russo
Summary: The release of molecules in exosomal cargoes is involved in tumor development and progression. This study compared the expression profiles of exosomal microRNAs released by two thyroid cancer cell lines with non-tumorigenic thyroid cells, and explored the network of miRNA-target interaction. Several microRNAs were found to be significantly deregulated in the exosomes of tumor cells compared to non-tumorigenic cells. Network analysis identified some genes as targets of more than one miRNAs. These findings provide insight into the role of exosomal microRNAs in aggressive PTC cells and their interaction with the tumor microenvironment.
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Angel Earle, Madison Bessonny, Josh Benito, Kun Huang, Hannah Parker, Emily Tyler, Brittany Crawford, Nabeeha Khan, Bridget Armstrong, Alexis Stamatikos, Sudha Garimella, Alyssa Clay-Gilmour
Summary: The early detection of chronic kidney disease is crucial, and there is growing interest in finding new biomarkers. Currently, there is no single effective biomarker, but there is evidence supporting the use of urinary exosomal microRNAs as biomarkers for kidney fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Janhavi R. Raut, Ben Schoettker, Bernd Holleczek, Feng Guo, Megha Bhardwaj, Kaya Miah, Petra Schrotz-King, Hermann Brenner
Summary: This study proposes a blood-based microRNA signature for identifying high-risk populations for colorectal cancer screening. Circulating microRNAs (miRNAs) are found to improve colorectal cancer risk prediction, with a 7-miRNA score showing higher predictive ability compared to environmental and polygenic risk scores.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Jing Zhang, Shiquan Li, Xiaona Zhang, Chao Li, Jiantao Zhang, Wenli Zhou
Summary: This study revealed that HLA-F-AS1 promotes migration, invasion, and EMT of CRC cells by competitively binding to miR-375 and inversely regulating its expression pattern. Moreover, PFN1 was identified as a direct target of miR-375, positively modulated by HLA-F-AS1, and affecting macrophage polarization. The overexpression of HLA-F-AS1 repressed miR-375 and promoted PFN1 expression pattern, further stimulating CRC cell proliferation and migration through macrophage interactions.
CANCER GENE THERAPY
(2021)
Review
Cell Biology
Sina Taghvimi, Omid Vakili, Elahe Soltani Fard, Seyyed Hossein Khatami, Neda Karami, Mortaza Taheri-Anganeh, Mahsa Salehi, Babak Negahdari, Hassan Ghasemi, Ahmad Movahedpour
Summary: Lung cancer therapeutic resistance, especially chemoresistance, remains a major challenge in treating this disease. Recent studies have shown that transfer of exosomes, specifically noncoding RNAs, plays a crucial role in lung cancer chemoresistance by modulating various proteins and genes. Understanding these molecular mechanisms can help improve lung cancer therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrei Sorop, Diana Constantinescu, Florentina Cojocaru, Anca Dinischiotu, Dana Cucu, Simona Olimpia Dima
Summary: Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and is often detected late due to its high clinical and biological heterogeneity. Small nanoparticles with an endosomal origin are valuable biomarkers or carriers for novel treatments in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Oncology
Veronica Zelli, Chiara Compagnoni, Roberta Capelli, Alessandra Corrente, Mauro Di Vito Nolfi, Francesca Zazzeroni, Edoardo Alesse, Alessandra Tessitore
Summary: Extracellular vesicles (EVs), including exosomes, play crucial roles in hepatocellular carcinoma (HCC) therapy. Exosomal miRNAs carried by EVs are involved in regulating tumor behavior, reshaping tumor microenvironment, and contributing to drug resistance mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Qirong Li, Dongxu Wang, Dayong Ding, Ye Feng, Ruizhi Hou, Dianfeng Liu, Chao Lin, Yongjian Gao
Summary: Exosomes, small vesicles containing complex RNA and proteins, play a crucial role in gastric and colorectal cancer by facilitating bidirectional communication between tumor cells and their microenvironment. They are involved in tumor cell proliferation, metastasis, immune response, drug resistance, and can serve as drug carriers in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Jiang Jiang, Wenfang Wang, Lan Zhu, Bowen Shi, Yong Chen, Yihan Xia, Weiming Feng, Weiwu Yao, Aiguo Lu, Huan Zhang
Summary: The crosstalk between tumor cells and macrophages under hypoxic conditions, facilitated by exosomes, plays a crucial role in promoting colorectal cancer (CRC) progression. This study explores the impact of hypoxic macrophage-derived exosomes (HMDEs) on CRC progression and identifies the underlying molecular mechanisms. It is found that HMDEs induce cell cycle transition and inhibit cell apoptosis, promoting CRC cell growth. The interaction between Hif-1 alpha and Hsp90, as well as Hsp90 and Lats1, is identified as the key molecular mechanism. These findings provide valuable insights into the complex interplay between macrophages and CRC cells in hypoxic conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jinwu Peng, Qiuju Liang, Zhijie Xu, Yuan Cai, Bi Peng, Jianbo Li, Wenqin Zhang, Fanhua Kang, Qianhui Hong, Yuanliang Yan, Mingyu Zhang
Summary: Exosomal miRNAs play important roles in glioma and may affect malignant behaviors and treatment response. They can serve as potential biomarkers for glioma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Manal A. Babaker, Fadwa A. Aljoud, Faris Alkhilaiwi, Abdulrahman Algarni, Asif Ahmed, Mohammad Imran Khan, Islam M. Saadeldin, Faisal A. Alzahrani
Summary: Colorectal cancer is a prevalent and deadly form of cancer. Current chemotherapy treatments are not selective, causing harm to healthy cells. Milk-derived extracellular vesicles offer potential as a natural alternative with the ability to suppress tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Peng Jin, Si-Jing Wu, Qian Ma, Wei Liu, Ying-Xin Zhao, Hong-Ya Han, Fang-Jie Hou, Ya Li, Yu-Jie Zhou
Summary: This study retrospectively explores the predictive value of the association between RDW and plaque vulnerability assessed by OCT in patients with cardiovascular diseases, and finds that a higher RDW is positively correlated with plaque vulnerability.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Article
Energy & Fuels
Zhiping Zhang, Xiaoni Fan, Shengnan Zhu, Peng Jin, Yinggang Jiao, Haorui Zhang, Quanguo Zhang, Yameng Li
Summary: This study evaluated the effects of different Tween series surfactants on hydrogen production in the photo-fermentative biohydrogen production (PFHP) process. It was found that Tween 80 was the most suitable surfactant, resulting in the highest cumulative hydrogen yield. Additionally, Tween 80 also significantly improved the growth and activity of photosynthetic bacteria.
Article
Multidisciplinary Sciences
Liujun Xu, Jinrong Liu, Peng Jin, Guoqiang Xu, Jiaxin Li, Xiaoping Ouyang, Ying Li, Cheng-Wei Qiu, Jiping Huang
Summary: The curved space-time produced by black holes leads to the intriguing trapping effect. So far, metadevices have enabled analogous black holes to trap light or sound in laboratory spacetime. However, trapping heat in a conductive environment is still challenging because diffusive behaviors are directionless.
NATIONAL SCIENCE REVIEW
(2023)
Article
Energy & Fuels
Yifan Yang, Yonghong Xu, Hongguang Zhang, Fubin Yang, Jing Ren, Xu Wang, Peng Jin, Denggao Huang
Summary: In this paper, hybrid energy storage system (HESS) is introduced into extended range electric vehicles (EREVs), and two energy management strategies based on HESS are proposed to reduce fuel consumption and prolong the service life of the battery. Simulation results show that the first hierarchical energy management strategy proposed in this study can effectively extend the service lifetime of the battery and reduce the fuel economy of EREVs.
Article
Multidisciplinary Sciences
Jing Ren, Yonghong Xu, Hongguang Zhang, Fubin Yang, Yifang Yang, Xu Wang, Peng Jin, Denggao Huang
Summary: This study focuses on the parameter identification and SOC estimation of ultracapacitors for electric vehicles. Using the FFRLS algorithm and EKF algorithm, the study shows that these methods have good adaptability and accuracy in estimating the SOC under different temperatures and working conditions.
Article
Thermodynamics
Binzhen Zhou, Jianjian Hu, Peng Jin, Ke Sun, Ye Li, Dezhi Ning
Summary: By studying a hybrid system consisting of a semi-submersible platform and heaving point absorber wave energy converters (WECs), this research has found that a new prominent power peak occurs in the so-called synchronized mode regardless of the layout of the WECs. In this mode, the power of a single WEC can increase by up to 41.4% and the total power by up to 26.7%, but the heave motion of the platform increases. The WECs have a small impact on the surge motion and pitch motion of the platform except for near the synchronized mode frequency, where they reduce the resonant heave motion at the natural frequency. This study provides valuable insights into the dynamic and power performance of wind-wave hybrid systems, offering detailed configurations and potential guidance for practical design and application.
Article
Multidisciplinary Sciences
Peng Jin, Jinrong Liu, Liujun Xu, Jun Wang, Xiaoping Ouyang, Jian-Hua Jiang, Jiping Huang
Summary: Thermal metamaterials provide rich control of heat transport by breaking the Onsager reciprocity and introducing thermal convection, leading to a regime beyond effective heat conduction. A continuous switch from thermal cloaking to thermal concentration is demonstrated in a liquid-solid hybrid thermal metamaterial with external tuning. This switch is achieved by tuning the liquid flow, resulting in a topology transition in the virtual space of the thermotic transformation. These findings illustrate the extraordinary heat transport in complex multicomponent thermal metamaterials and pave the way toward an unprecedented regime of heat manipulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Chemical
Daoguang Teng, Peng Jin, Shiqiao Yang, Wenhuan Guo, Zhuang Zhao, Guoli Zhou, Peng Li, Yijun Cao
Summary: Cost-effective polycyclic aromatic hydrocarbons (PAHs) were used to fabricate hyper-cross-linked polymers (HCLPs) via an external cross-linker knitting method (ECLKM) followed by N-source impregnation modification. The resulting materials exhibited high thermal stability, large specific surface areas, narrow pore distributions, and high pore volumes. The effects of porosities and N-doping modification on the CO2 capture capacities of HCLPs were fully studied, and it was found that porosities played a dominant role in the CO2 uptake process compared to N-doping modification. This study provides a simple strategy for constructing HCLPs with excellent CO2 capture performances using PAHs.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Mechanics
Bin-zhen Zhou, Zhi Zheng, Yu Wang, Peng Jin, Lin Cui, Liang Cheng
Summary: An optimization method is proposed to determine the dimensions of a hybrid system consisting of a spar-type floating offshore wind turbine and a heaving annular wave energy converter (WEC). The synchronized mode, where the natural frequency of the system matches the peak wave frequency, is found to be the most effective in terms of wave energy production.
JOURNAL OF HYDRODYNAMICS
(2023)
Article
Physics, Applied
Fubao Yang, Peng Jin, Min Lei, Gaole Dai, Jun Wang, Jiping Huang
Summary: The proposed space-time-coding electromagnetic metasurface introduces the temporal dimension into artificial structure design, expanding its digital application in information processing. However, the absence of temporal dimension in thermal digital metamaterial limits the synergetic modulation of thermal signal in time and space. This study introduces temporal modulation into existing spatially variable thermal coding structures and proposes a space-time thermal binary coding scheme, demonstrating a practical strategy for thermal binary coding and providing a prototype for spatiotemporal regulation of thermal signal.
PHYSICAL REVIEW APPLIED
(2023)
Article
Chemistry, Multidisciplinary
Kai Wang, Feng Wan, Ling Luo, Pengyu Cao, Lei Han, Peng Jin
Summary: This paper investigates the buckling enhancement of the negative Poisson's ratio (NPR) effect on a laminated plate under uniaxial compression with an in-plane translational restraint. By studying the buckling equation and lamination parameters, it is found that the critical buckling load of an NPR-laminated composite can be increased due to the induced tension force on the unloaded direction under compression. The Poisson's ratio contours and buckling load enhancement are analyzed, and the inverse problem of deciding the laminate configuration is solved using the particle swarm optimization (PSO) algorithm.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Peng Jin, Liujun Xu, Guoqiang Xu, Jiaxin Li, Cheng-Wei Qiu, Jiping Huang
Summary: Heat-enhanced thermal diffusion metamaterials powered by deep learning enable automatic temperature sensing and adjustment with high tunability and stable thermal performance.
ADVANCED MATERIALS
(2023)
Article
Engineering, Marine
Binzhen Zhou, Qi Zhang, Jianjian Hu, Peng Jin, Hengming Zhang, Siming Zheng
Summary: The wave power absorption of a heaving-body wave energy converter can be improved by deploying it near a coastal wall, harbour pier, or breakwater and making it highly asymmetric. This research proposes a semi-analytical model to analyze the coupling between the geometric asymmetry of the converter and the partial reflecting boundaries of the walls. Results show that the wall increases the power performance by increasing the reflection rate.
Article
Chemistry, Inorganic & Nuclear
Wangqiang Shen, Lei Lou, Yiao Wei, Lipiao Bao, Guangqing Xu, Peng Jin, Jun Lv, Xing Lu
Summary: In this study, a dysprosium-containing mono-EMF with a C-84 cage, possessing rare D-2(21) symmetry, was successfully synthesized. Theoretical calculations revealed that the encapsulation of a trivalent Dy ion in the carbon cage is energetically more favorable than other C-84-based mono-EMFs. This work not only expands the trivalent mono-EMF family but also provides insights into the unique structures and stabilities of such novel EMFs.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Peng Jin, Junyan Zhang, Dapeng Wang, Nan Li, Leibo Liu
Summary: In this study, an adapted PC-CFR module is proposed for the transceiver design in Sub-6GHz 5G-NR scenarios. It successfully reduces the Peak to Average Power Ratio (PAPR) and has been implemented on ASIC with MATLAB simulation analysis.
2022 IEEE 5TH INTERNATIONAL CONFERENCE ON ELECTRONICS AND COMMUNICATION ENGINEERING, ICECE
(2022)
