Article
Medicine, Research & Experimental
Mengdi Shang, Yiyang Wu, Yeyang Wang, Yanfei Cai, Jian Jin, Zhaoqi Yang
Summary: This study developed a strategy using nanoparticles to co-deliver antisense oligonucleotides and photosensitizers into tumor cells, effectively inhibiting proliferation and metastasis of triple negative breast cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ana R. Rama, Francisco Quinonero, Cristina Mesas, Consolacion Melguizo, Jose Prados
Summary: This study presents a circular RNA-based miRNA capture system for studying the role of miR-21 in lung cancer. The miR-21 circular sponge was found to inhibit the growth, colony formation, and migration of lung cancer cells, indicating the potential of this method as a tool for capturing other miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ana R. Rama, Patricia Lara, Cristina Mesas, Francisco Quinonero, Celia Velez, Consolacion Melguizo, Jose Prados
Summary: miR-21 is upregulated in breast cancer and plays a role in drug resistance and carcinogenic processes. Capture of miR-21 using a circular sponge (Circ-21) inhibits proliferation, migration, colony formation, and enhances antitumor activity in breast cancer cells. Circ-21 also increases PARP-1 expression, inhibits VEGF expression, and arrests cell cycle. It shows potential for effective gene therapy in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Anna Mizielska, Iga Dziechciowska, Radoslaw Szczepanski, Malgorzata Cisek, Malgorzata Dabrowska, Jan Slezak, Izabela Kosmalska, Marta Rymarczyk, Klaudia Wilkowska, Barbara Jacczak, Ewa Toton, Natalia Lisiak, Przemyslaw Kopczynski, Blazej Rubis
Summary: One of the most innovative medical trends is personalized therapy, which focuses on detecting unique features of cancer cells. The miRNA family may serve as good prognostic and diagnostic markers for breast cancer. This study evaluated changes in selected miRNA levels in breast cancer cell lines treated with doxorubicin or cisplatin, and identified potential miRNAs that respond to these treatments.
Review
Biochemistry & Molecular Biology
Owen Dawson, Anna Maria Piccinini
Summary: miRNA strand selection is an important process in miRNA regulation, and its selection and functionality are closely related to areas such as immunity and cancer.
Article
Environmental Sciences
Prasenjit Mitra, Taru Goyal, Preeti Singh, Shailja Sharma, Praveen Sharma
Summary: The study found that miR-155 and miR-221 were significantly upregulated in occupationally lead-exposed workers, while miR-20b showed no significant difference. These miRNAs have the potential to trigger various genes and cellular pathways, highlighting the importance of miRNA dysregulation in the systemic effects of lead toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Oncology
Poonam Yadav, Priyanshu Sharma, Sandhya Sundaram, Ganesh Venkatraman, Amal Kanti Bera, Devarajan Karunagaran
Summary: miR-5096 induces ferroptotic cell death in breast cancer cells by targeting and downregulating SLC7A11, reducing ROS, lipid peroxides, and iron accumulation levels, as well as decreasing GSH levels and mitochondrial membrane potential, inhibiting cell survival, migration, and invasion.
Article
Cell Biology
Chi Pan, Guangzhi Sun, Min Sha, Peng Wang, Yawen Gu, Qingtao Ni
Summary: The study demonstrated that miR-93-5p can reduce the proliferation and migratory capacity of breast cancer cells, increase the ratio of apoptotic cells, and enhance the radiosensitivity of BC cells through increased apoptosis. This indicates that miR-93-5p could be a potential therapeutic target for breast cancer treatment.
Review
Immunology
Salar Pashangzadeh, Morteza Motallebnezhad, Fatemeh Vafashoar, Azadeh Khalvandi, Nazanin Mojtabavi
Summary: miRNAs, especially miR-155, play crucial roles in immune system regulation, and their altered expression and function may contribute to vulnerability to autoimmune diseases and significant dysfunction of the immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
You-Zhe Lin, Shu-Hsuan Liu, Wan-Rong Wu, Yi-Chun Shen, Yuan-Liang Wang, Chien-Ching Liao, Pei-Le Lin, Han Chang, Liang-Chih Liu, Wei-Chung Cheng, Shao-Chun Wang
Summary: This study identifies miR-4759 as a novel non-coding RNA that enhances anti-tumor immune response in breast cancer by targeting the PD-L1 gene. In patients with breast cancer, downregulation of miR-4759 is associated with poor prognosis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Somayeh Hashemi Sheikhshabani, Zeinab Amini-Farsani, Shima Rahmati, Ali Jazaeri, Marzieh Mohammadi-Samani, Samira Asgharzade
Summary: The study revealed that oleuropein regulated the expression of miRNAs in ovarian cancer cells, potentially resulting in apoptosis induction, cell proliferation inhibition, and decline in cisplatin resistance. Further experiments in animal models of ovarian cancer are suggested to confirm the findings.
Article
Materials Science, Biomaterials
Qingyan Zhang, Ying Huang, Ruoxi Yang, Junmei Mu, Zhanwei Zhou, Minjie Sun
Summary: This study developed a poly-antioxidant to deliver anti-miR-155 for synergistic treatment of metastatic breast cancer by scavenging reactive oxygen species and inhibiting miR-155. The novel nanoplatform effectively blocked the NF-kappa B pathway, demonstrating strong anti-metastatic ability both in vitro and in vivo.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Applied
Judie Magura, Daniel Hassan, Roshila Moodley, Irene Mackraj
Summary: The study demonstrated that Hesperidin nanoemulsions (HP-NEM) selectively exhibit cytotoxic effects against MCF-7 cells through apoptosis induction, G2/M cell cycle arrest, and downregulation of miR-21 and miR-155 expression, without harming normal cells. This suggests the potential use of HP-NEM as a therapeutic agent in breast cancer treatment.
JOURNAL OF MICROENCAPSULATION
(2021)
Article
Medicine, Research & Experimental
Nastaran Injinari, Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Hossein Teimori
Summary: miR-34a and miR-520h are implicated in the apoptosis pathways, with decreased expression in cancer tissues and VPA inducing apoptosis and affecting their expression. VPA can be a possible option in breast cancer research due to its impact on the regulation of miRNAs and HDAC1.
Article
Urology & Nephrology
Sonat Pinar Kara, Gulsum Ozkan, Ahsen Yilmaz, Nergiz Bayrakci, Savas Guzel, Elif Geyik
Summary: The study revealed significantly higher levels of miRNA 21 and aldosterone in patients with resistant hypertension compared to healthy individuals and newly diagnosed hypertensives.
Article
Biochemistry & Molecular Biology
Laleh Heidari, Sayyed Mohammad Hossein Ghaderian, Milad Bastami, Shadi Hosseini, Saeed Alipour Parsa, Sahel Heidari, Hossein Jafari, Nasim Sohrabifar, Maryam Pirhoushiaran
Summary: This study evaluated the expression level, methylation profile, and polymorphisms of SIRT1 and HDAC9 genes in CAD patients. The results suggest that the expression changes of these genes may serve as potential biomarkers for CAD detection.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Oncology
Khandan Ilkhani, Soheila Delgir, Asma Safi, Farhad Seif, Azam Samei, Milad Bastami, Mohammad Reza Alivand
Summary: The study found that miR-130a-5p is downregulated in breast cancer tissues, potentially acting as a tumor suppressor. miR-615-3p did not show significant differences between tumor and non-tumor tissues. Subgroup studies did not reveal significant correlations between the expression of these miRNAs and subfactors.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Asma Safi, Milad Bastami, Soheila Delghir, Khandan Ilkhani, Farhad Seif, Mohammad R. Alivand
Summary: Cisplatin is widely used for treating malignant tumors but resistance remains a major challenge. Recent studies highlight the importance of Cancer Stem Cell (CSC)-derived drug resistance, particularly in Breast Cancer Stem Cells (BCSCs) when it comes to cisplatin sensitivity. Understanding the role of miRNAs in regulating cisplatin resistance/sensitivity can lead to more effective personalized anti-cancer therapies.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Ziba Nariman-Saleh-Fam, Yaser Mansoori, Zahra Saadatian, Javad Tavakkoly-Bazzaz, Abdolreza Daraei, Sepideh Zununi Vahed, Habibollah Mahmoodzadeh, Milad Bastami
Summary: This study evaluated the expression of miR-146a and its target genes in the peripheral blood mononuclear cells (PBMCs) of ESCC patients. The results showed that miR-146a was upregulated, while its target genes IRAK1 and TRAF6 were downregulated in PBMCs of ESCC patients. NF-kappa B1 and IL6 were also downregulated in PBMCs of ESCC patients. These findings suggest a downregulatory mechanism of immune responses in PBMCs of ESCC patients.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Review
Cell Biology
Mohammadreza Ardalan, Seyed Mahdi Hosseiniyan Khatibi, Yalda Rahbar Saadat, Milad Bastami, Ziba Nariman-Saleh-Fam, Sima Abediazar, Rovshan Khalilov, Sepideh Zununi Vahed
Summary: Podocytes are highly specialized kidney epithelial cells that can release injury-related migrasomes. pEVs, especially migrasomes, appear to be more sensitive and reliable indicators of podocyte stress and/or damage than proteinuria in the early stages of kidney diseases.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Medical Laboratory Technology
Zahra Firoozi, Elham Mohammadisoleimani, Abbas Shahi, Hosein Mansoori, Mohammad Mehdi Naghizadeh, Milad Bastami, Ziba Nariman-Saleh-Fam, Abdolreza Daraei, Atefeh Raoofat, Yaser Mansoori
Summary: This study evaluated the expression levels of hsa_circ_0005986 and hsa_circ_000839 in tumors and adjacent normal tissues of breast cancer patients, and their associations with clinicopathological characteristics. The results showed that the expression levels of hsa_circ_0005986 and hsa_circ_000839 were lower in tumor tissues compared to adjacent tissues. The study also identified potential ceRNA networks involving these circRNAs, which included mRNAs and miRNAs with crucial roles in breast cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Oncology
Deniz Mortazavi, Behnoush Sohrabi, Meysam Mosallaei, Ziba Nariman-Saleh-Fam, Milad Bastami, Yaser Mansoori, Abdolreza Daraei, Sepideh Zununi Vahed, Shadan Navid, Zahra Saadatian, Tannaz Jamialahmadi, Yong Teng, Amirhossein Sahebkar
Summary: Cancer is a major cause of death and disability worldwide. Epigenetic deregulation, particularly involving microRNAs, plays a crucial role in carcinogenesis by affecting histone modification. Understanding the role of microRNAs in histone modification machinery can lead to the identification of novel therapeutic targets and early detection strategies for better management of cancer patients.
JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zahra Foruzandeh, Davood Ghavi Dorabadi, Farzaneh Sadeghi, Fatemeh Zeinali-Sehrig, Mohammad Zaefizadeh, Yazdan Rahmati, Mohammad Reza Alivand
Summary: Effective prognostic and diagnostic tools are urgently needed for the detection and treatment of triple-negative breast cancer. Circular RNAs have been discovered as potential biomarkers for TNBC, and they can modulate gene expression. This review summarizes the dysregulated expression of circRNAs and their diagnostic and prognostic values in TNBC.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Morteza Gholami, Marziyeh Zoughi, Roobic Behboo, Reza Taslimi, Alireza Kazemeini, Milad Bastami, Shirin Hasani-Ranjbar, Bagher Larijani, Mahsa M. Amoli
Summary: This study found that variants of rs7473 and rs1547715 are associated with the risk of obesity and colorectal cancer respectively, based on their interactions with miRNAs.
Article
Biochemistry & Molecular Biology
Zahra Mahdavi Niyaki, Ali Salehzadeh, Maryam Peymani, Mohammad Zaefizadeh
Summary: This study investigates the role of lncRNA in the KRAS pathway in colorectal cancer (CRC) and highlights the therapeutic potential of Fe3O4@Glu-Oleuropein. The findings provide insights into the underlying mechanisms and offer avenues for further research in targeted cancer therapies.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Neurosciences
Kamelia Mobasheri, Mohammad Zaefizadeh, Maryam Ghobeh, Akram Eidi
Summary: This study aims to explore the use of a neuropeptide nano shuttle to deliver quercetin to the brains of AD model rats. The results showed that the nano shuttle significantly improved the histopathology, behavioral testing, and expression of AD-related genes in the AD rats.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Medicine, General & Internal
Mohammadreza Ardalan, Elham Ahmadian, Seyed Mahdi Hosseiniyan Khatibi, Yalda Rahbar Saadat, Milad Bastami, Yasin Bagheri, Fatemeh Zununi Vahed, Mohammadali M. Shoja, Sepideh Zununi Vahed
Summary: Glomerular injury is a major cause of CKD worldwide, and it may be associated with dysbiosis of gut microbiota. Dysbiosis can activate immune responses, leading to inflammation and proteinuria in the kidneys. Therapeutic interventions through modulation of gut microbiota can be effective in treating GN.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Correction
Cell Biology
Tooba Yousefi Digesaraei, Sadra Samavarchi Tehrani, Maryam Abolghasemi, Ansar Karimian, Amir Valizadeh, Niloufar Targhazeh, Milad Bastami, Farhad Jadidi-Niaragh, Mehdi Yousefi, Hossein Samadi Kafil, Maryam Majidinia, Bahman Yousefi
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
