Review
Pharmacology & Pharmacy
Marta Bryk, Elzbieta Karnas, Jakub Mlost, Ewa Zuba-Surma, Katarzyna Starowicz
Summary: MSCs, as multipotent progenitor cells derived from mesoderm, have been extensively studied for their regenerative properties, including the release of EVs which play a role in their functions. They regulate various processes in target cells and show potential applications in pain treatment and other diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rui Alvites, Mariana Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Ana Colette Mauricio
Summary: Mesenchymal Stem/Stromal Cells (MSCs) have high clinical value and have been extensively studied. Their immunomodulatory influence occurs through both direct and paracrine routes, but the mechanisms are not fully understood. This review summarizes the immunoregulatory capacity of MSCs and their secretion products, with a focus on migration, homing, direct cell action, and paracrine activity, and explores related techniques.
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Review
Biochemistry & Molecular Biology
Kotaro Tanaka, Ryohei Ogino, Sho Yamakawa, Shota Suda, Kenji Hayashida
Summary: Skin wounds usually heal on their own, but this is only true for healthy individuals. Mesenchymal stem cells (MSCs) have been found to play a significant role in wound healing and regeneration, with their ability to self-renew and differentiate, as well as their anti-inflammatory and immunomodulatory properties. This review aims to explain the functions and effects of MSCs in wound healing.
Article
Cell Biology
Hugo Abreu, Elena Canciani, Davide Raineri, Giuseppe Cappellano, Lia Rimondini, Annalisa Chiocchetti
Summary: Tissue regeneration is a hot topic in health sciences. Studying the relationship between mesenchymal stem/stromal cells (MSCs), extracellular vesicles (EVs), and biomaterials is important for the treatment of musculoskeletal diseases.
Review
Cell Biology
Soudeh Ghafouri-Fard, Vahid Niazi, Bashdar Mahmud Hussen, Mir Davood Omrani, Mohammad Taheri, Abbas Basiri
Summary: Extracellular vesicles play important roles in cell-cell communication, inflammation modulation, cell proliferation, and tissue regeneration, with advantages such as lower risk and easier production and storage compared to cell therapy. Particularly, exosomes derived from mesenchymal stem cells are introduced as a therapeutic option for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bocheng Zhang, Xiaoyuan Tian, Zhenan Qu, Jun Hao, Weiguo Zhang
Summary: This study aimed to compare the effects of hypoxia-preconditioned and normoxia-preconditioned MSC-EVs on OA cartilage repair, as well as to investigate the impact of hypoxia on microRNA expression in MSC-EVs. The results demonstrated that hypoxia-preconditioned MSC-EVs exhibited superior effects in enhancing chondrocyte proliferation and migration and suppressing chondrocyte apoptosis compared to normoxia-preconditioned MSC-EVs. Additionally, bioinformatics analysis revealed that hypoxia may promote cartilage repair through the miRNA-18-3P/JAK/STAT or miRNA-181c-5p/MAPK signaling pathway.
Article
Neurosciences
P. Vatsa, R. Negi, U. A. Ansari, V. K. Khanna, A. B. Pant
Summary: Mesenchymal stem cells (MSCs) are multipotent adult stem cells found in various tissues, showing promise in treating neurodegenerative diseases. Extracellular vesicles (EVs) derived from MSCs carry biologically active molecules for intercellular communication, serving as potential cell-free therapies with therapeutic cargo and ethical advantages.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Qian Wei, Xi Liu, Jian-Long Su, Ya-Xi Wang, Zi-Qiang Chu, Kui Ma, Qi-Lin Huang, Hai-Hong Li, Xiao-Bing Fu, Cui-Ping Zhang
Summary: Chronic non-healing wounds pose a significant threat to both the physical and mental health of patients, with abnormal behavior of remaining cells identified as the main obstacle to healing. Mesenchymal stem cells (MSCs) therapy has emerged as a promising option for chronic wound healing, primarily due to their exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs) have been reported to regulate cellular behavior and have a positive impact on various stages of wound healing. This review discusses the characteristics and therapeutic potential of MSC-sEVs in chronic wound treatment, as well as their application avenues and strategies for large-scale production and engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Michael Nguyen-Truong, Peiman Hematti, Zhijie Wang
Summary: MSCs have been studied for nearly two decades as a therapy for myocardial restoration, with a focus on their paracrine function. Utilizing MSC-derived cell-free approaches for regenerative therapy comes with advantages and disadvantages, and involves mechanisms such as angiogenesis and immunomodulation. Researchers are working towards enhancing these properties to improve therapeutic outcomes, while facing remaining challenges in the field.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ciarra Almeria, Sebastian Kress, Viktoria Weber, Dominik Egger, Cornelia Kasper
Summary: Extracellular vesicles (EVs) are cell-derived membrane structures that play a major role in physiological and pathological processes by delivering biomolecules to target cells. Many effects previously attributed to cell-based therapies are actually mediated by EVs, suggesting the use of purified EVs instead of living cells for therapy. This review focuses on the heterogeneity of EVs derived from mesenchymal stem/stromal cells (MSC) and summarizes the upstream parameters that critically affect their therapeutic properties and biological functions.
CELL AND BIOSCIENCE
(2022)
Review
Neurosciences
Milena B. P. Soares, Renata G. J. Goncalves, Juliana F. Vasques, Almir J. Da Silva-Junior, Fernanda Gubert, Girlaine Cafe Santos, Thais Alves de Santana, Gabriela Louise Almeida Sampaio, Daniela Nascimento Silva, Massimo Dominici, Rosalia Mendez-Otero
Summary: Neurological disorders have limited treatment options, and there is a need for cell-based therapies. Mesenchymal stem/stromal cells (MSCs) have been widely studied but no cell-based treatment for neurological diseases currently exists. This review explores the therapeutic potential of MSC-based therapies for neurological disorders and discusses challenges in culture conditions, quality control, and the development of potency tests to improve cell therapy products for these conditions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Francesca Libonati, Laura de Girolamo
Summary: BMSCs and PRP-based therapies have potential for treating osteoarthritis. This study explores the effects of PRP on BMSCs' regenerative properties and characterizes the secretome in terms of soluble factors and EV-embedded miRNAs. The results indicate that PRP-treated BMSCs release therapeutic molecules that attract and modulate immune cell migration, have anti-inflammatory effects, and regulate cartilage destruction pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yasunari Matsuzaka, Ryu Yashiro
Summary: Extracellular vesicles (EVs) are lipid bilayer membrane particles that play critical roles in intracellular communication. Mesenchymal stem cells (MSCs) induce tissue regeneration by direct recruitment into injured tissues or secreting factors. Recent studies have shown that MSC-derived EVs have regenerative effects against various diseases and can serve as drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Zi-Yi Feng, Shu-De Yang, Ting Wang, Shu Guo
Summary: Melatonin, synthesized in the pineal gland, controls the body's circadian rhythm and has various effects including regulating metabolism, providing neuroprotection, and acting as an anti-inflammatory and free radical scavenger. Research has shown that melatonin can play a role in regulating MSCs, which have the potential for tissue regeneration through paracrine signaling. MSC-derived extracellular vesicles (EVs) could potentially offer advantages over MSCs in regenerative medicine due to their ability to respond to injury and promote tissue regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Samira Abbaszadeh-Mashkani, Shahanara Sunjida Hoque, Hamid Reza Banafshe, Amir Ghaderi
Summary: The study showed that supplementation of crocin for 12 weeks in patients under MMT programs had beneficial effects on craving and withdrawal symptoms score. However, it did not affect the cognitive function parameters such as TMT, FAS test, and DGSP score.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Morteza Kosari, Mehdi Noureddini, Seyed Peyman Khamechi, Ahmad Najafi, Amir Ghaderi, Mojtaba Sehat, Hamid Reza Banafshe
Summary: In this study, syrup containing propolis and Hyoscyamus niger L. extract showed beneficial effects in ameliorating the signs and symptoms of COVID-19 disease, reducing symptoms like dry cough, shortness of breath, sore throat, chest pain, fever, etc., compared to the placebo group.
PHYTOTHERAPY RESEARCH
(2021)
Article
Substance Abuse
Soheil Bagheri, Ahmad Reza Saghazade, Samira Abbaszadeh-Mashkani, Hamid Reza Banafshe, Fatemeh Sadat Ghoreishi, Azam Mesdaghinia, Amir Ghaderi
Summary: This study demonstrated that vitamin D supplementation in smokers can increase serum vitamin D levels, alleviate symptoms of depression, and improve various metabolic markers.
JOURNAL OF ADDICTIVE DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Maryam Akbari, Maryam Saleh Mohammadnia, Masoumeh Ghalkhani, Mohammad Aghaei, Esmail Sohouli, Mehdi Rahimi-Nasrabadi, Mohsen Arbabi, Hamid Reza Banafshe, Ali Sobhani-Nasab
Summary: A new electrochemical sensor has been developed to accurately measure fentanyl by measuring its oxidation current in aqueous solutions. The study demonstrates that a glassy carbon electrode modified with a nanocomposite of multi-walled carbon nanotube, hydroxyapatite, and copper-based metal-organic framework (MWCNT-HA/Cu-H3BTC) (GCE/MWCNT-HA/Cu-H3BTC) can achieve sensitive detection of fentanyl, with excellent reproducibility and stability.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Substance Abuse
Abbas Azadbakht, Mehrdad Salehi, Mohammad Reza Maracy, Hamid Reza Banafshe
Summary: This study aimed to evaluate the effects of oxytocin (OXT) on craving, mental health, and stress hormones in methamphetamine (METH)-dependent patients undergoing matrix treatment model (MTM). The results showed that OXT administration for 4 weeks significantly improved craving and depression scores, but did not have a significant effect on anxiety scores. Additionally, OXT administration significantly decreased cortisol and ACTH levels.
EUROPEAN ADDICTION RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Ali Abedini, Mojtaba Rostami, Hamid Reza Banafshe, Mehdi Rahimi-Nasrabadi, Ali SobhaniNasab, Mohammad Reza Ganjali
Summary: Nanotechnology focuses on the production and application of compounds in nanoscale. Environmentally friendly procedures are now being proposed for the fabrication of Fe nanoparticles due to the use of large quantities of toxic materials and harsh conditions in their preparation. This article provides an overview of the green and biological methods for synthesizing Fe nanoparticles and their potential biomedical applications, especially in drug delivery, bioimaging, antibacterial, and anticancer activities.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Amir Ghaderi, Amir Hossein Khoshakhlagh, Masoome Irani, Azam Ghaseminezhad, Prem Gautam, Nezam Mirzaei, Hamid Reza Banafshe, Bahador Nemati, Heshmatollah Moradpour Ghalerashidi
Summary: This study investigated the levels of heavy metals and elements in urine and blood of hookah users and non-users, as well as their clinical symptoms. Results showed significantly higher levels of lead, arsenic, and thallium in hookah users compared to non-users, along with common clinical symptoms of constipation and fatigue. These findings can guide policy development to regulate hookah smoking and prevent associated health risks.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biodiversity Conservation
Amir Ghaderi, Mahdiyeh Mohammadzadeh, Hamid Reza Banafshe, Seyed Gholam Abbas Mousavi, Nezam Mirzaei, Zeinab Parmoozeh, Gholamreza Mostafaei, Morad Rasouli-Azad, Heshmatollah Moradpour Ghalerashidi, Reza Fouladi-Fard
Summary: This study evaluated the concentrations of heavy metals in smoked and non-smoked cigarette butts and assessed the associated health risks. The results showed that heavy metal concentrations were significantly higher in smoked cigarette butts compared to non-smoked ones. Nickel and cadmium in Iranian and other brands indicated potential non-carcinogenic risks, while chromium showed a potential carcinogenic risk in all brands. Continuous monitoring and regulation of cigarette ingredients are recommended.
HUMAN AND ECOLOGICAL RISK ASSESSMENT
(2023)
Article
Behavioral Sciences
Mahbubeh Saeedfar, Abolfazl Ardjmand, Behrang Alani, Amir Ghaderi, Hamid Reza Banafshe, Mohammad Esmaeil Shahaboddin, Gholamreza Ghavipanjeh
Summary: Vitamin D has been found to be associated with substance abuse and dependence, potentially through its effect on dopamine signaling pathway. The study suggests that vitamin D can be considered as an effective therapeutic approach for narcotic addiction and substance abuse. These findings have important implications for the treatment of drug addiction.
BRAIN AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Fateme Padoei, Peyman Mamsharifi, Pooya Hazegh, Homa Boroumand, Fatemeh Ostadmohammady, Samira Abbaszadeh-Mashkani, Hamid Reza Banafshe, Amir Hassan Matini, Amir Ghaderi, Somayeh Ghadami Dehkohneh
Summary: This study found that oral NAC can improve depression and anxiety symptoms, as well as some metabolic profiles, in SUD patients undergoing MMT for 12 weeks.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, Legal
Hamidreza Sadeghi-Gandomani, Hamid Reza Banafshe, Zohreh Sadat, Ghaderi Amir, Shirvanizadeh Fatemeh, Mohammad Afshar, Narges Naseri-Borujeni
Summary: This study aimed to determine the effects of crocin from saffron on sleep quality, general health, and happiness in the elderly. A total of 70 elderly individuals were divided into intervention and control groups, with the intervention group receiving 30 mg/day of crocin and the control group receiving a placebo. The results showed that the consumption of crocin improved sleep quality, general health, and happiness in the elderly.
INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE
(2023)
Article
Chemistry, Medicinal
Sayyed Alireza Talaei, Hamid Reza Banafshe, Alireza Moravveji, Mohammad Shabani, Shiva Shirazi Tehrani, Alireza Abed
Summary: This study investigated the effects of black seed oil (BSO) on neuropathic pain. The results showed that chronic administration of BSO significantly reduced heat hyperalgesia and mechanical allodynia. However, daily administration of BSO did not affect cold allodynia. Further research is needed to confirm the effectiveness of BSO in neuropathic pain conditions.
RESEARCH IN PHARMACEUTICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Amene Taghdisi Kashani, Samane Shamollaghamsari, Amir Hossein Mohammadi, Hamid Reza Banafshe, Amir Ghaderi
Summary: The study found that a majority of patients undergoing methadone maintenance treatment exhibited Vitamin D deficiencies and poor oral health, but there was no significant relationship between the DMFT index and Vitamin D levels.
INTERNATIONAL ARCHIVES OF HEALTH SCIENCES
(2022)
Article
Immunology
Farshid Fathi, Reza F. Saidi, Hamid Reza Banafshe, Mohsen Arbabi, Majid Lotfinia, Hossein Motedayyen
Summary: This study revealed that HCC patients show significant changes in immune cells compared to healthy individuals, with reductions in CD4(+) cells, Tbet+IFN gamma+cells, and GATA+IL-4+cells, and an increase in Foxp3+CD127(low)cell frequency. The numbers of Th1, Th2, and Th17 cells were significantly lower, while Treg percentage was significantly higher in HCC patients. Immune cell frequencies differed among patients with different TNM stages of HCC, suggesting a potential association between immune changes and disease progression.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Ali-Reza Abed, Alireza Abed, Hamid Reza Banafshe, Ebadallah Shiri Malekabad, Sattar Gorgani-Firuzjaee, Ali-Reza Dadashi
Summary: Biotin shows potential in relieving mechanical allodynia and heat hyperalgesia in neuropathic pain, suggesting it as a therapeutic option. However, acute oral administration of biotin did not significantly reduce pain sensitivity compared to chronic use.
RESEARCH IN PHARMACEUTICAL SCIENCES
(2021)